Gastric Acidity in Patients with Follicular Gastritis is Significantly Reduced, but Can be Normalized After Eradication for <i>Helicobacter pylori</i>

Shimatani, Tomohiko; Inoue, Masakí; Iwamoto, Keiko; Hyogo, Hideyuki; Yokozaki, Michiya; Saeki, Toshinari; Tazuma, Susumu; Horikawa, Yoko; Harada, Nobue

doi:10.1111/j.1523-5378.2005.00318.x

Cited by 24 publications

(26 citation statements)

References 46 publications

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“…The group of subjects younger than 30 years had a high prevalence of NG at 11.1%, while there was no NG patient in the group of subjects older than 50 years. The female predominance of NG found here is consistent with previous studies [5,7,20,29]. A pattern of male predominance has been reported for peptic ulcers, whereas H. pylori infection shows no gender predilection [30].…”

Section: Discussionsupporting

confidence: 92%

Clinical Characteristics and the Expression Profiles of Inflammatory Cytokines/Cytokine Regulatory Factors in Asymptomatic Patients with Nodular Gastritis

Hong

Jang

et al. 2012

Dig Dis Sci

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Section: Discussionsupporting

confidence: 92%

Clinical Characteristics and the Expression Profiles of Inflammatory Cytokines/Cytokine Regulatory Factors in Asymptomatic Patients with Nodular Gastritis

Hong

Jang

et al. 2012

Dig Dis Sci

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“…A recent study evaluated these markers separately and reported higher risk for gastric cancer in comparison to the ratio [26]. Several studies have looked on the association between pepsinogens and topography of gastritis [27], [28], [29], [30]. Among these studies which used PGII or PGI/PGII ratio, either absence of association [31], or presence of association with pangastritis was reported comparing with corpus-spared gastritis [32], [33], [34].…”

Section: Discussionmentioning

confidence: 99%

Accuracy and Cut-Off Values of Pepsinogens I, II and Gastrin 17 for Diagnosis of Gastric Fundic Atrophy: Influence of Gastritis

et al. 2011

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BackgroundTo establish optimal cutoff values for serologic diagnosis of fundic atrophy in a high-risk area for oesophageal squamous cell carcinoma and gastric cancer with high prevalence of Helicobacter pylori (H. pylori) in Northern Iran, we performed an endoscopy-room-based validation study.MethodsWe measured serum pepsinogens I (PGI) and II (PGII), gastrin 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA) antigen among 309 consecutive patients in two major endoscopy clinics in northeastern Iran. Updated Sydney System was used as histology gold standard. Areas under curves (AUCs), optimal cutoff and predictive values were calculated for serum biomarkers against the histology.Results309 persons were recruited (mean age: 63.5 years old, 59.5% female). 84.5% were H. pylori positive and 77.5% were CagA positive. 21 fundic atrophy and 101 nonatrophic pangastritis were diagnosed. The best cutoff values in fundic atrophy assessment were calculated at PGI<56 µg/l (sensitivity: 61.9%, specificity: 94.8%) and PGI/PGII ratio<5 (sensitivity: 75.0%, specificity: 91.0%). A serum G-17<2.6 pmol/l or G-17>40 pmol/l was 81% sensitive and 73.3% specific for diagnosing fundic atrophy. At cutoff concentration of 11.8 µg/l, PGII showed 84.2% sensitivity and 45.4% specificity to distinguish nonatrophic pangastritis. Exclusion of nonatrophic pangastritis enhanced diagnostic ability of PGI/PGII ratio (from AUC = 0.66 to 0.90) but did not affect AUC of PGI. After restricting study samples to those with PGII<11.8, the sensitivity of using PGI<56 to define fundic atrophy increased to 83.3% (95%CI 51.6–97.9) and its specificity decreased to 88.8% (95%CI 80.8–94.3).ConclusionsAmong endoscopy clinic patients, PGII is a sensitive marker for extension of nonatrophic gastritis toward the corpus. PGI is a stable biomarker in assessment of fundic atrophy and has similar accuracy to PGI/PGII ratio among populations with prevalent nonatrophic pangastritis.

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“…Although H. pylori -induced chronic atrophic gastritis is characterized by marked infiltration of Th1 and Th17 cells, the majority of the inflamed gastric mucosa also contains focal lymphoid aggregates with germinal centers 67. Autoantibodies against tumor-associated antigens are very attractive biomarkers for the development of serological tests for early cancer detection.…”

Section: Host Immune System and Gastric Cancermentioning

confidence: 99%

Immune Response and the Tumor Microenvironment: How They Communicate to Regulate Gastric Cancer

2014

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Gastric cancer is the second most common cause of cancer-related death in the world. A growing body of evidence indicates that inflammation is closely associated with the initiation, progression, and metastasis of many tumors, including those of gastric cancer. In addition, approximately 60% of the world's population is colonized by Helicobacter pylori, which accounts for more than 50% of gastric cancers. While the role of inflammation in intestinal and colonic cancers is relatively well defined, its role in stomach neoplasia is still unclear because of the limited access of pathogens to the acidic environment and the technical difficulties isolating and characterizing immune cells in the stomach, especially in animal models. In this review, we will provide recent updates addressing how inflammation is involved in gastric malignancies, and what immune characteristics regulate the pathogenesis of stomach cancer. Also, we will discuss potential therapeutics that target the immune system for the efficient treatment of gastric cancer.

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Gastric Acidity in Patients with Follicular Gastritis is Significantly Reduced, but Can be Normalized After Eradication for Helicobacter pylori

Abstract: In follicular gastritis, gastric acidity is significantly reduced, but can be normalized by eradication of H. pylori. It can thus be speculated that inflammatory cytokines or H. pylori-infection-induced prostaglandins might strongly inhibit gastric acid secretion in follicular gastritis.

Cited by 24 publications

References 46 publications

Clinical Characteristics and the Expression Profiles of Inflammatory Cytokines/Cytokine Regulatory Factors in Asymptomatic Patients with Nodular Gastritis

Clinical Characteristics and the Expression Profiles of Inflammatory Cytokines/Cytokine Regulatory Factors in Asymptomatic Patients with Nodular Gastritis

Accuracy and Cut-Off Values of Pepsinogens I, II and Gastrin 17 for Diagnosis of Gastric Fundic Atrophy: Influence of Gastritis

Immune Response and the Tumor Microenvironment: How They Communicate to Regulate Gastric Cancer

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