Clinical Characteristics and the Expression Profiles of Inflammatory Cytokines/Cytokine Regulatory Factors in Asymptomatic Patients with Nodular Gastritis

Hong, Sung Noh; Jo, Seunghyun; Jang, Ju Hyun; Choi, Jida; Kim, Soohyun; Ahn, Soo Y.; Kim, Jeong Hwan; Choe, Won Hyeok; Lee, Sun-Young; Sung, In Kyung; Park, Hyung Seok; Shim, Chan Sup

doi:10.1007/s10620-012-2053-3

Cited by 16 publications

(11 citation statements)

References 46 publications

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“…These results are consistent with previous reports that described intracellular IL-32 expression and leakage from apoptotic cells (12,13,26). Note that neutrophil proteinase 3, an IL-32 binding protein that is expressed in neutrophils and monocytes, is highly expressed in H. pylori-related gastritis (18). IL-32 from damaged epithelial cells may activate myeloid cells through an IL-32-neutrophil proteinase 3 interaction to enhance inflammation of gastric tissue.…”

Section: Discussionsupporting

confidence: 93%

Role of Interleukin-32 in Helicobacter pylori-Induced Gastric Inflammation

et al. 2012

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cHelicobacter pylori infection is associated with gastritis and gastric cancer. An H. pylori virulence factor, the cag pathogenicity island (PAI), is related to host cell cytokine induction and gastric inflammation. Since elucidation of the mechanisms of inflammation is important for therapy, the associations between cytokines and inflammatory diseases have been investigated vigorously. Levels of interleukin-32 (IL-32), a recently described inflammatory cytokine, are increased in various inflammatory diseases, such as rheumatoid arthritis and Crohn's disease, and in malignancies, including gastric cancer. In this report, we examined IL-32 expression in human gastric disease. We also investigated the function of IL-32 in activation of the inflammatory cytokines in gastritis. IL-32 expression paralleled human gastric tissue pathology, with low IL-32 expression in H. pylori-uninfected gastric mucosa and higher expression levels in gastritis and gastric cancer tissues. H. pylori infection increased IL-32 expression in human gastric epithelial cell lines. H. pylori-induced IL-32 expression was dependent on the bacterial cagPAI genes and on activation of nuclear factor B (NF-B). IL-32 expression induced by H. pylori was not detected in the supernatant of AGS cells but was found in the cytosol. Expression of the H. pylori-induced cytokines CXCL1, CXCL2, and IL-8 was decreased in IL-32-knockdown AGS cell lines compared to a control AGS cell line. We also found that NF-B activation was decreased in H. pylori-infected IL-32-knockdown cells. These results suggest that IL-32 has important functions in the regulation of cytokine expression in H. pylori-infected gastric mucosa.

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Section: Discussionsupporting

confidence: 93%

Role of Interleukin-32 in Helicobacter pylori-Induced Gastric Inflammation

et al. 2012

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“…It is clear that the 74 potency of IL-33 for activating several immunocytes probably impacts inflammation. For 75 example, IL-33 is expressed by patients with chronic gastritis, chronic hepatitis, and 76 inflammatory bowel disease [15][16][17]. Inflammatory diseases increase the risk of developing 77 cancer, suggesting that IL-33 may play an important role in cancer pathogenesis [18,19].…”

Section: Introduction 51 52mentioning

confidence: 99%

Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue

Ishikawa¹,

Yagi-Nakanishi²,

Nakanishi³

et al. 2014

Auris Nasus Larynx

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“…The authors stated that the clinical implication of this finding was unclear because the range of the 95 % CI was notably wide and a positive association between NG and gastric neoplasm could not be found in the subgroup analysis comparing the Helicobacter pylori (-) controls or H. pylori (?) controls [1].The association between NG and gastric cancer have been previously suggested by various reports [2,3]. The major limitation of these series and the present study is the small size of the study populations.…”

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confidence: 59%

“…

I read with great interest the article by Hong et al [1]. They analyzed clinico-epidemiological characteristics of 52 patients with nodular gastritis (NG) and 2,527 controls.

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confidence: 99%

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Is Nodular Gastritis a Precancerous Condition?

Önal

2012

Dig Dis Sci

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I read with great interest the article by Hong et al. [1]. They analyzed clinico-epidemiological characteristics of 52 patients with nodular gastritis (NG) and 2,527 controls. Gastric neoplasm was detected in a single patient in the NG group (1.9 %) and in five patients in the control group (0.2 %). In this study NG was associated with increased gastric neoplasia, including gastric adenoma and adenocarcinoma based on multivariate analysis (odds ratio = 10.52, 95 % CI [1.20-92.0]). The authors stated that the clinical implication of this finding was unclear because the range of the 95 % CI was notably wide and a positive association between NG and gastric neoplasm could not be found in the subgroup analysis comparing the Helicobacter pylori (-) controls or H. pylori (?) controls [1].The association between NG and gastric cancer have been previously suggested by various reports [2,3]. The major limitation of these series and the present study is the small size of the study populations. It is not possible to conclude a significant relationship between NG and gastric cancer with a few malignant cases in each series. This subject necessitates a large population-based follow-up study from an epidemiological perspective.Another important point to note is that a plausible association between NG and gastric cancer should be supported by clinical and pathological evidence. We showed that the frequency of gastric ulcer (3.8 vs 7.1 %), atrophic gastritis (4.9 vs 12 %) and gastric polyp (2.2 vs 0.5 %) was not significantly more frequent in patients with NG [4]. Only 8.1 % of our patients had pangastritis and less than 5 % had nodules in other parts of the stomach. For this reason, topographically, NG cannot be regarded as a type of pangastritis (so a precursor of atrophic gastritis) as some authors suggested [3]. There was no case of gastric cancer among our 185 patients with NG [4]. In another study we examined the pathological characteristics of the cases with NG [5]. Our results showed that there was no difference between the patients with NG and the control regarding the features as presence of severe dysplasia, inflammatory activity, intestinal metaplasia and lymphoid hyperplasia.In conclusion NG cannot be accepted as a precancerous condition under the light of the pertinent literature.

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Clinical Characteristics and the Expression Profiles of Inflammatory Cytokines/Cytokine Regulatory Factors in Asymptomatic Patients with Nodular Gastritis

Abstract: Asymptomatic NG is associated with H. pylori infection, and a predilection for this condition exists in young females. The PR3 expression of gastric mucosa might play an important role in the pathogenesis of NG.

Cited by 16 publications

References 46 publications

Role of Interleukin-32 in Helicobacter pylori-Induced Gastric Inflammation

Role of Interleukin-32 in Helicobacter pylori-Induced Gastric Inflammation

Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue

Is Nodular Gastritis a Precancerous Condition?

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