Gastric acidity in carcinoma of the stomach

Comfort, Mandred W.; Vanzant, Frances R.

doi:10.1016/s0002-9610(34)90446-3

Cited by 13 publications

(3 citation statements)

References 5 publications

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“…In 1879, von den Velden reported that gastric cancer was linked to achlorhydria 3–6 (Figure 2). This observation suggested the availability of a possible simple diagnostic test and prompted many investigations into the relation between gastric cancer and acid secretion as well as studies regarding measurement of gastric secretion itself (reviewed in 7–9). …”

Section: History Of Gastric Cancer In Relation To Gastric Atrophy/atrmentioning

confidence: 99%

“…This was a period in which gastric atrophy and gastric cancer were still common in Western countries (Figure 3) 4 such that investigators had a wealth of clinical material to examine. For example, in 1934 Comfort and Vanzant reported studies on 619 men and 186 women with gastric cancer seen at the Mayo clinic between 1927 and 1931 7. They compared acid secretion of patients with cancer to those of normal individuals of similar age and sex and showed that the proportion with achlorhydria in both gastric cancer and normal individuals increased with age.…”

Section: History Of Gastric Cancer In Relation To Gastric Atrophy/atrmentioning

confidence: 99%

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Eradication of gastric cancer and more efficient gastric cancer surveillance in Japan: two peas in a pod

Graham

Asaka

2009

J Gastroenterol

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We provide a historical review and update on current thinking regarding the possibility of elimination of gastric cancer from Japan. Because Helicobacter pylori infection is the cause gastric cancer, its elimination forms the cornerstone of eradication of gastric cancer. However, simply eradicating H. pylori from the entire population will not immediately solve the problem because many patients with H. pylori infections have already developed the precursor lesion, atrophic gastritis. Cure of H. pylori in these high risk patients will only reduce the risk of subsequent cancer. In contrast, treatment of low risk patients will prevent cancer. Thus, to eliminate gastric cancer it is necessary to identify and treat all infected individuals. In addition, those at increased risk for gastric cancer (ie, atrophic gastritis irrespective a age) should be considered for endoscopic surveillance to identify those cancers that do develop at an early stage. We propose that selection be based on severity and extent of atrophy be used to separate those expected to benefit from endoscopy and annual surveillance from those with little or no potential benefit. We suggest an algorithm for eradicating gastric cancer that incorporates H. pylori and atrophic gastritis testing, H. pylori therapy, and surveillance. Institution of a program of surveillance restricted to those who could benefit most (ie, those with moderate or severe atrophy). This will also allow a much closer matching of surveillance capacity and surveillance need making surveillance more clinically and cost effective.

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Section: History Of Gastric Cancer In Relation To Gastric Atrophy/atrmentioning

confidence: 99%

Section: History Of Gastric Cancer In Relation To Gastric Atrophy/atrmentioning

confidence: 99%

Eradication of gastric cancer and more efficient gastric cancer surveillance in Japan: two peas in a pod

Graham

Asaka

2009

J Gastroenterol

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“…Helicobacter pylori is now recognized as etiologically responsible for gastritis-associated peptic ulcer disease, the majority of gastric cancers as well as gastric MALT lymphoma. Proof of these etiological associations capped decades of work on the natural history of gastritis and its relation to disease [6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Time Trends in Helicobacter pylori Infection and Atrophic Gastritis Over 40 Years in Japan

et al. 2015

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Small Gastric Cancer

Comfort¹

1954

Arch Intern Med

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A GASTRIC cancer of small size always arouses the hope that it is more amenable to therapy and possesses a better prognosis than gastric cancer in general. Do the facts justify this hope? Does the small gastric cancer differ in any way from gastric cancers of all sizes ? Can it be removed more safely ? Are survival rates better for small cancers ? Analysis of records of a group of small gastric cancers has in general provided affirmative answers to these questions. MATERIALDuring the years 1940 to 1945, inclusive, 924 adenocarcinomas of the stomach were treated by gastric resection at the Mayo Clinic. In 226 of these, the greatest diameter measured 4 cm. or less. Thus, gastric cancer of this size accounts for about one quarter of all gastric cancer treated by resection. The importance of this group in the over-all survival rate of patients with gastric cancer is obvious.For purposes of study, these 226 small gastric cancers were subdivided according to size into four smaller groups, thus providing data about cancers of varying degrees of smallness. The greatest diameter measured 1.0 cm. or less in 18 cases (8%), from 1.1 to 2.0 cm. in 49 (21.7%), from 2,1 to 3.0 cm. in 67 (29.6%), and from 3.1 to 4.0 cm. in 92 (40.7%) of the 226 cases. Lymphosarcomas were excluded from the study so that survival rates would pertain only to adenocarcinomas.

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Gastric acidity in carcinoma of the stomach

Cited by 13 publications

References 5 publications

Eradication of gastric cancer and more efficient gastric cancer surveillance in Japan: two peas in a pod

Eradication of gastric cancer and more efficient gastric cancer surveillance in Japan: two peas in a pod

Time Trends in Helicobacter pylori Infection and Atrophic Gastritis Over 40 Years in Japan

Small Gastric Cancer

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