Gasotransmitter signaling in energy homeostasis and metabolic disorders

Ali, Amr; Wang, Yuehong; Wu, Lingyun; Yang, Guangdong

doi:10.1080/10715762.2020.1862827

Cited by 19 publications

(11 citation statements)

References 279 publications

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“…Gasotransmitters, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H 2 S), are of great significance to maintaining body homeostasis, regulating a series of pathophysiological processes, including vascular function, 4 inflammation, 5 glucose, and lipid metabolism. 6 In the last decade, gas therapy has emerged as a promising strategy for cancer treatment with minor side effects. 7 H 2 S shows bell-shaped effects toward tumor cells: low concentration (below nM level) of H 2 S is procancer, while high concentration (above μM level) of exogenous H 2 S is anticancer.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mesoporous Organosilica-Based Hydrogen Sulfide Nanogenerator for Enhanced Tumor Chemotherapy

Zhu

Yao

et al. 2023

ACS Appl. Nano Mater.

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Conventional chemotherapy is bothered by systematic toxicity and confined therapeutic effects. Gas therapy has emerged as a potent tumor treatment, and hydrogen sulfide (H 2 S), a traditional gasotransmitter, has been found to show a tumor inhibition effect. Therefore, we established a mesoporous organosilica-based H 2 S nanogenerator (MON-TPGS-DOX). Tetrasulfide bond-incorporated mesoporous organosilica nanoparticles were modified with D-α-tocopheryl polyethylene glycol succinate (TPGS), namely, MON-TPGS, and then loaded with doxorubicin (DOX) to obtain the nanogenerator. Tetrasulfide bonds in the nanogenerator could be triggered by glutathione (GSH) to release H 2 S, further resulting in the degradation of nanogenerator and DOX release. GSH consumption and H 2 S release led to oxidative stress in 4T1 cells, activation of apoptotic signaling cascades, and enhanced cell-killing effect. Furthermore, the nanogenerator effectively suppressed tumor growth in a tumor-bearing mice model with good biosafety, providing a promising approach for H 2 Senhanced tumor chemotherapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mesoporous Organosilica-Based Hydrogen Sulfide Nanogenerator for Enhanced Tumor Chemotherapy

Zhu

Yao

et al. 2023

ACS Appl. Nano Mater.

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“…[6,[13][14][15] Recently, there has been growing interest in the development of bioorthogonal activation of prodrugs for the delivery of gasotransmitters, including carbon monoxide, hydrogen sulfide, and nitric oxide, which are now recognized to play vital roles in endogenous signaling pathways. [16][17][18][19][20] Dysregulation of hydrogen sulfide (H 2 S), one of the endogenous gasotransmitters for oxidative/reductive stress regulation, is linked to cardiovascular, gastrointestinal, neurological, and endocrine diseases. [21][22][23] One likely mechanism for H 2 S-linked disease development is its role in regulating energy production in mitochondria.…”

Section: Introductionmentioning

confidence: 99%

“…For example, extensive work has been done on the activation of anticancer prodrugs using the Staudinger‐Bertozzi ligation, [11] strain‐promoted 1,3‐dipolar cycloadditions between azides and trans ‐cyclooctene, [12] and inverse‐electron‐demand Diels‐Alder cycloadditions (IEDDA) between tetrazines and trans ‐cyclooctenes [6,13–15] . Recently, there has been growing interest in the development of bioorthogonal activation of prodrugs for the delivery of gasotransmitters, including carbon monoxide, hydrogen sulfide, and nitric oxide, which are now recognized to play vital roles in endogenous signaling pathways [16–20] …”

Section: Introductionmentioning

confidence: 99%

Pyranthiones/Pyrones: “Click and Release” Donors for Subcellular Hydrogen Sulfide Delivery and Labeling**

Huang,

Gunawardhana,

Zhang

et al. 2023

Chemistry A European J

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Hydrogen sulfide (H2S), one of the most important gasotransmitters, plays a critical role in endogenous signaling pathways of many diseases. However, developing H2S donors with both tunable release kinetics and high release efficiency for subcellular delivery has been challenging. Here, we describe a click and release reaction between pyrone/pyranthiones and bicyclononyne (BCN). This reaction features a release of CO2/COS with second‐order rate constants comparable to Strain‐Promoted Azide‐Alkyne Cycloaddition reactions (SPAACs). Interestingly, pyranthiones showed enhanced reaction rates compared to their pyrone counterparts. We investigated pyrone biorthogonality and demonstrated their utility in protein labeling applications. Moreover, we synthesized substituted pyranthiones with H2S release kinetics that can address the range of physiologically relevant H2S dynamics in cells and achieved quantitative H2S release efficiency in vitro. Finally, we explored the potential of pyranthiones as H2S/COS donors for mitochondrial‐targeted H2S delivery in living cells.

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“…2 Studies have revealed that gasotransmitters control the generation of adenosine triphosphate (ATP), insulin sensitivity, and metabolism of glucose and lipids, and hence abnormal production of gasotransmitters is responsible for different metabolic diseases such as diabetes and obesity. 3 Furthermore, gasotransmitters are essential signalling molecules in inflammatory reactions, 4 and can also exhibit different protective roles against oxidative stress. 1 In general, gasotransmitters have a beneficial role if produced at low concentrations but lead to toxicity at higher concentrations.…”

Section: Introductionmentioning

confidence: 99%