Gas-related impact of pneumoperitoneum on systemic wound healing

Rösch, R.; Junge, K.; Binnebösel, Marcel; Mirgartz, N.; Klinge, U.; Schumpelick, Volker

doi:10.1007/s00423-006-0136-3

Cited by 9 publications

(14 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most commonly used parameters to evaluate the healing process include clinical assessment of animals, tensile strength, analysis of anti-inflammatory activity, collagenous tissue expressed by hydroxyproline concentration or morphometric analysis, and histopathological analysis using optical microscopy [10][11][12] . Among these parameters, measurement of tensile strength is particularly relevant in cases of intervention through the abdominal wall, because tensile strength testing provides accurate and prompt results and reflects the reality of clinical practice, in which a pulling force is exerted on the surgical wound whenever patients contract their abdomen 9,11,13 .…”

Section: Discussionmentioning

confidence: 99%

“…Throughout the three phases, the scar tissue is arranged so that progressive collagen formation and remodeling can be observed [9][10][11][12]16 .…”

Section: Discussionmentioning

confidence: 99%

“…However, in the same period, the use of helium to create the pneumoperitoneum has been shown to increase collagen synthesis 10,12 .…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that CO 2 pneumoperitoneum may affect tensile strength, because a decrease in pH is observed in the subcutaneous, intraarterial, and intra-abdominal tissue after the creation of a CO 2 pneumoperitoneum, a fact that leads to suppression of cellular differentiation of lineages derived from monocytes (which have a role in healing), thus altering collagen formation locally and systemically 10,12,17 .…”

Section: Discussionmentioning

confidence: 99%

“…Potential effects of chemical and cellular magnitude, such as those observed in metalloproteinases or peritoneal macrophage concentration, can be regarded as minimal, thus failing to promote changes in the criteria analyzed and, consequently, failing to present important clinical significance 4,8,10,12,17 .…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Evaluation of the effects of carbon dioxide pneumoperitoneum on abdominal wall wound healing in rats undergoing segmental resection and anastomosis of the left colon

Morais¹,

Farias²,

Duraes³

et al. 2012

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE: To evaluate the influence of carbon dioxide pneumoperitoneum on abdominal wall wound healing in rats. METHODS: Eighty rats underwent laparotomy, segmental left colon resection, and anastomosis. The animals were divided into three experimental groups and one control group: EI = pneumoperitoneum for 30 minutes before laparotomy (n=20); EII = pneumoperitoneum for 30 minutes after abdominal closure (n=20); EIII = pneumoperitoneum for 30 minutes before laparotomy and 30 minutes after abdominal closure (n=20); C = control group, without pneumoperitoneum (n=20). In each group, 10 animals were killed 7 days and 10 animals 14 days postoperatively. A segment of the abdominal wall was resected and subjected to tensile strength testing. Another segment of abdominal muscle was used for histopathological analysis; the specimens were fixed in formalin and stained with hematoxylin and eosin. RESULTS: There were no differences in histopathology and tensile strength values among animals in the experimental and control groups 7 or 14 days after surgery. CONCLUSION: Under the present experimental conditions, carbon dioxide pneumoperitoneum did not interfere with abdominal wall wound healing.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Throughout the three phases, the scar tissue is arranged so that progressive collagen formation and remodeling can be observed [9][10][11][12]16 .…”

Section: Discussionmentioning

confidence: 99%

“…However, in the same period, the use of helium to create the pneumoperitoneum has been shown to increase collagen synthesis 10,12 .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of the effects of carbon dioxide pneumoperitoneum on abdominal wall wound healing in rats undergoing segmental resection and anastomosis of the left colon

Morais¹,

Farias²,

Duraes³

et al. 2012

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

Influence of small intestinal serosal defect closure on leakage rate and adhesion formation: a pilot study using rabbit models

Binnebösel

Klink

Grommes

et al. 2010

Langenbecks Arch Surg

View full text Add to dashboard Cite

Closure of isolated serosal injuries with resorbable suture material was associated with an adhesion formation in distressing certainty, whereas no leakage or fistula formation could be observed at all. Further studies are needed to clarify the impact of serosal defect closure in particular on leakage rate and fistula formation, e.g., with pre-existing adhesions, in case of multiple serosal injuries or with a pre-existing peritonitis.

show abstract

Suturing method as a factor for uterine vascularity after laparoscopic myomectomy

Fujimoto

Morimoto

Hosokawa

et al. 2017

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

show abstract

Gas-related impact of pneumoperitoneum on systemic wound healing

Abstract: Our results suggest beneficial effects on systemic wound healing for helium pneumoperitoneum as compared to CO(2).

Cited by 9 publications

References 39 publications

Evaluation of the effects of carbon dioxide pneumoperitoneum on abdominal wall wound healing in rats undergoing segmental resection and anastomosis of the left colon

Evaluation of the effects of carbon dioxide pneumoperitoneum on abdominal wall wound healing in rats undergoing segmental resection and anastomosis of the left colon

Influence of small intestinal serosal defect closure on leakage rate and adhesion formation: a pilot study using rabbit models

Suturing method as a factor for uterine vascularity after laparoscopic myomectomy

Contact Info

Product

Resources

About