Gas foamed open porous biodegradable polymeric microspheres

Kim, Taek Kyoung; Yoon, Jun Jin; Lee, Sang Soo; Park, Tae Gwan

doi:10.1016/j.biomaterials.2005.05.081

Cited by 324 publications

(222 citation statements)

References 26 publications

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“…Sodium bicarbonate is the most widely used gas foaming agent given that it generates CO 2 in acidic conditions. [21] However, other carbonates such as potassium carbonate and ammonium bicarbonate [51,52] as well as nitrites such as sodium nitrite [53] have also been reported. The ultimate choice of foaming agent decided based on cost and the safety of both the gas by-products produced as well as the residual products left behind within the formed gel, with the latter considerations particularly important to consider for biomedical applications.…”

Section: Gas Foamingmentioning

confidence: 99%

Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities

Hoare

2017

Adv Healthcare Materials

170

168

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Structured macroporous hydrogels that have controllable porosities on both the nanoscale and the microscale offer both the swelling and interfacial properties of bulk hydrogels as well as the transport properties of “hard” macroporous materials. While a variety of techniques such as solvent casting, freeze drying, gas foaming, and phase separation have been developed to fabricate structured macroporous hydrogels, the typically weak mechanics and isotropic pore structures achieved as well as the required use of solvent/additives in the preparation process all limit the potential applications of these materials, particularly in biomedical contexts. This review highlights recent developments in the field of structured macroporous hydrogels aiming to increase network strength, create anisotropy and directionality within the networks, and utilize solvent‐free or additive‐free fabrication methods. Such functional materials are well suited for not only biomedical applications like tissue engineering and drug delivery but also selective filtration, environmental sorption, and the physical templating of secondary networks.

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Section: Gas Foamingmentioning

confidence: 99%

Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities

Hoare

2017

Adv Healthcare Materials

170

168

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“…Also, higher PLGA concentrations result in a higher viscosity of the oil phase, which restricts the transport of the inner phase material towards the outer phase [30]. The diffusion of the inner phase material is also influenced by the size of the particle [14]. These conditions help explain why smaller particles have a lower encapsulation efficiency.…”

Section: Encapsulation Efficiencymentioning

confidence: 99%

“…By changing the lactic/glycolic acid ratio of the PLGA molecules it is possible to control the degradation rate. PLGA has been used to prepare tablets to be ingested, scaffolds, nanoparticles for inhalers or intravenous injections and microparticles for subcutaneous depot [4][5][6][7]9,12,[14][15][16][17]. The work reported here produced particles in the range of 40 to 140 µm via membrane emulsification followed by the solvent removal method to produce the PLGA microspheres.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of PLGA particles for subcutaneous controlled drug release by membrane emulsification

Gasparini

Kosvintsev

Stillwell

et al. 2008

Colloids and Surfaces B: Biointerfaces

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“…Scaffold berpori yang dibuat untuk implantasi baik ukuran maupun bentuk harus disesuaikan dengan bentuk jaringan yang rusak. [9,10] .…”

Section: Pendahuluanunclassified

FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT

Fitriani¹,

Suciati²

2015

J.Ris.Kim.

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Poly (D,L-lactide acid) has been used as scaffold for tissue engineering. In this study, PDLLA microparticles were made into porous microparticles. Porous microparticles were proposed to reduce burst release of protein and to prevent diffusion of released protein into non-target tissue. Formulation of porous microparticles was made by water-oil-water (W1/O/W2) emulsification-solvent evaporation using gas foamed as porogen. Variations of the amount of sodium bicarbonate, volume of citric acid solution and time for homogenization were optimized to produce optimum formulation. Evaluation for this microparticles included morphology of particles, particle size distribution and porosity. Porous microparticle produced by ratio volume of acid : dichloromethane : poly(vynil alcohol) (PVA) = 1:3:3 and the ratio of sodium bicarbonate : PDLLA = 2:3 was the optimum formulation.

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Gas foamed open porous biodegradable polymeric microspheres

Cited by 324 publications

References 26 publications

Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities

Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities

Preparation and characterization of PLGA particles for subcutaneous controlled drug release by membrane emulsification

FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT

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