Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Aqueous Extract of Daniellia oliveri Stem Bark

Yakubu, Ojochenemi Ejeh; Otitoju, Olawale; Onwuka, Joshua

doi:10.4172/2153-2435.1000568

Cited by 19 publications

(12 citation statements)

References 3 publications

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“…The variation in the abundance is in agreement with [1] that, different extracts possesses unique physicochemical characteristics which may be due to the molecular weight of the chemical entities as the compounds are naturally present in significant quantities. This is also in agreement with the work of [33], who identified D. oliveri from its ethnobotanical and industrial importance. In this study, the GC-MS analysis of methanolic leaf extract revealed the presence of Benzo[h]quinoline, 2,4-dimethyl-, similar to the work of [34] that, fused quinoline derivatives produce antimalarial effects.…”

Section: Discussionsupporting

confidence: 92%

GC-MS Analysis and Antiplasmodial Potentials of Bioactive Compounds Present in Methanolic and Ethanolic Leaf Extracts of Daniella oliveri

Muazu

Sani

Dikwa

et al. 2022

AJBGMB

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Qualitative, quantitative and Gas Chromatography-Mass Spectrometry (GC-MS) analysis are useful for the determination of bioactive components necessary for accessing the antiplasmodial potentials of methanolic and ethanolic leaf extracts of Daniella oliveri (D. oliveri). The aim of the study was to screen D. oliveri for the detection of phytochemical components and determination of bioactive compounds using qualitative, quantitative and Gas Chromatography-Mass Spectroscopy (GC-MS) analytical techniques. The leaves were collected in Anyigba, from which methanolic and ethanolic extracts were prepared, phytochemical components detected and bioactive compounds determined using GC-MS. Results showed the presence of alkaloid, tannin, reducing sugar, saponin, terpenoid, phenol, cardiac glycosides and flavonoid in the extracts. Phenol showed the highest concentration (46.14 and 43.09 mg/100g) while terpenoid showed the lowest concentration (10.63 and 9.97 mg/100g) in methanolic and ethanolic extracts respectively. GC-MS analysis revealed the presence of higher components (57) in methanolic extract compared to ethanolic extract (27). This study provides scientific evidence that methanol may be a better extraction solvent for GC-MS analysis of D. oliveri leaves meant to be used for the determination of antiplasmodial activity than ethanol due to higher components detected in methanolic extract compared to ethanolic extract.

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Section: Discussionsupporting

confidence: 92%

GC-MS Analysis and Antiplasmodial Potentials of Bioactive Compounds Present in Methanolic and Ethanolic Leaf Extracts of Daniella oliveri

Muazu

Sani

Dikwa

et al. 2022

AJBGMB

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“…n-Hexadecanoic acid acts as antioxidant and anti-inflammatory [35]. cis-Vaccenic acid act as anti-asthmatic, antiinflammatory and lowers total cholesterol and triglycerides levels [28,36]. Octadecanoic acid is used hypercholesterolemic, antiarthiritic, antiinflammatory, hepatoprotective, nematicide and antimicrobial [28].…”

Section: Gc-ms Analysis Of T Indica Leaves Aqueous Extractmentioning

confidence: 99%

Analysis of Bioactive Chemical Compounds of Leaves Extracts from Tamarindus indica Using FT-IR and GC-MS Spectroscopy

Mehdi

Alawi

Thabet³

et al. 2021

AJRB

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Tamarindus indica is one of the medicinal plants used in the treatment of various diseases traditionally. Aims: This study was conducted to identify the phytochemical constituents of T. indica leaf extracts. Methods: Using Fourier-transform infrared spectroscopy (FT-IR) and gas chromatography-mass spectrometry (GC-MS) to identification of bioactive compounds in extracts of T. indica. Results: The FT-IR spectrum confirmed the presence of alcohol group, alkene group, amine group, carbonates, ethers, carboxylic acid and disulfides in both extracts. A total of 22 and 38 bioactive phytochemical compounds were identified in the ethanolic and aqueous extracts of T. indica, respectively. The major bioactive compounds of the ethanolic extract of T. indica leaves were cis-Vaccenic acid, trans-13-Octadecenoic acid, Oleic Acid, Octadecanoic acid, Octadecanoic acid, 2-(2-hydroxyethoxy) ethyl ester, Eicosanoic acid and Eicosane, 1-Iodo-2-methylundecane, 10-Methylnonadecane. While the major bioactive compounds of the aqueous extract were 3-O-Methyl-d-glucose, Myo-Inositol, 4C-methyl-, Myo-Inositol, 2-C-methyl-, Propane, 2,2-dimethoxy-, 1,3-Dioxolane, Ethanol, 2-(1-methylethoxy)-, and 2-Pentanone, 4-hydroxy-4-methyl-, 2-Hexanol, 2-methyl-, Ethanamine, N-methyl.

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“…Hexadecanoic acid (palmitic acid) is a fatty acid and it has been suggested as an active antimicrobial and antidiarrhoeal agent [70]. It was also documented by Yakubu et al [71] that Hexadecanoic acid is an anti-inflammatory agent and antioxidant. It has been suggested that 9,12-Octadecadienoic acid and oleic acid prevent the development of adreno-leuko dystrophy (ALD), a disease that damages the brain and the adrenal glands.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study on GC-MS Profiles and Effect of Ethanolic Extracts of Stem-Bark and Leaves of Daniellia oliveri on Cerebral Sodium Pump and Thiols Status in Fenton Reaction Treated Rat Organs In-vitro

Ale

Asuelimen

Ayo

et al. 2023

AJRB

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Daniellia oliveri is one of the most extensively utilized medicinal plants in Nigeria and some West African countries for the treatment of various ailments. In the present study, the GC-MS profiles and effect of ethanolic extracts of stem bark and leaves of Daniellia oliveri on lipid peroxidation, Na+/K+-ATPase activity and thiols status in H2O2 and Fe2+ (fenton reaction) assaulted cerebral and hepatic tissue homogenates was investigated. The stem bark and leaves were extracted with absolute ethanol for 72hrs and concentrated in a rotary evaporator. Wistar rats were euthanized and the brains and livers were removed, homogenized, centrifuged and the supernatants were used for lipid peroxidation, Na+/K+-ATPase activity, and thiol assays in the presence of prooxidants (1mM H2O2 or 10μM Fe2+ or H2O2 and Fe2+).The results revealed that ethanol extract of both the leaf and stem-bark inhibited lipid peroxidation induced by H2O2, Fe2+ and combination of H2O2 and Fe2+ and this was evident in the reduction of lipid peroxidation adducts formation in rat liver and brain homogenates with the stem-bark possessing more efficacy. Furthermore, the results of Na+/K+-ATPase and thiol assays revealed that H2O2 and Fe2+ inhibited the activity of cerebral Na+/K+-ATPase, while H2O2/Fe2+ caused a marked reduction in the levels of both protein and non-protein thiols in the tissues homogenates. However, the ethanolic extract of Daniellia oliveri extirpated this anomaly by increasing the activity of cerebral Na+/K+-ATPase as well as the thiol level in the rat hepatic and cerebral tissues. Finally, GC-MS analysis was carried out on the ethanolic extracts of the stem bark and leaves of Daniellia oliveri and results revealed the presence of 21 compounds including 1,2-Benzisothiazol-3-amine, 1H-Indole-2-carboxylic acid, 2-Ethylacridine, Ethyl 2-(2-chloroacetamido)-3,3,3-trifluoro-2-(3-fluoroanilino) propionate and trans-1-Butyl-2-methylcyclopropane in the stem bark and 10 compounds including Methylthio-acetonitrile, 2-Methyl-Z,Z-3,13-octadecadienol, Desulphosinigrin and 4H-1,2,4-triazole-3,5-diamine in the leaves, justifying the observed biological activities of Daniellia oliveri and the higher potency of the stem bark may be attributed to the presence of more bioactive constituents found in it. This study therefore justifies the medicinal usage of leaves and stem-bark of Daniellia oliveri and suggests its consideration in the treatment and management of degeneration diseases with etiology associated with oxidative stress.

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Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Aqueous Extract of Daniellia oliveri Stem Bark

Cited by 19 publications

References 3 publications

GC-MS Analysis and Antiplasmodial Potentials of Bioactive Compounds Present in Methanolic and Ethanolic Leaf Extracts of Daniella oliveri

GC-MS Analysis and Antiplasmodial Potentials of Bioactive Compounds Present in Methanolic and Ethanolic Leaf Extracts of Daniella oliveri

Analysis of Bioactive Chemical Compounds of Leaves Extracts from Tamarindus indica Using FT-IR and GC-MS Spectroscopy

A Comparative Study on GC-MS Profiles and Effect of Ethanolic Extracts of Stem-Bark and Leaves of Daniellia oliveri on Cerebral Sodium Pump and Thiols Status in Fenton Reaction Treated Rat Organs In-vitro

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