Gas chromatography–mass spectrometry-based trimethylsilyl-alditol derivatives for quantitation and fingerprint analysis of Anemarrhena asphodeloides Bunge polysaccharides

Xia, Yueyuan; Wang, Tianlong; Sun, Hanwen; Liang, Jun; Kuang, Hai‐Xue

doi:10.1016/j.carbpol.2018.06.066

Cited by 45 publications

(15 citation statements)

References 36 publications

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“…Other compounds examined are α‐tocopherol (vitamin E) (Liebler et al, ), hydroxypipecolic acids (Kitew & Hughes, ), menthols (Bournot et al, ), tetracyclines (Tsuji & Robertson, ), hydroxynoraporphines (Evans & Vouros, ), nicotinamine (Ripperger, ), flavonoids (Füzfai & Molnár‐Perl, ), bisphenol A (Szyrwińska et al, ), phytoestrogens (Ferrer et al, ), haplamine (Ea et al, ), cucurbic acid (Rontani et al, ), mycolic acids (Kaneda et al, ), N , N ‐dialkyl aminoethane‐2‐ols (Reddy et al, ), tricothecenes (Rodrigues‐Fo et al, ), β‐diketone‐containing plant waxes (Tulloch & Hogge, ), alkoxychlorohydrins (Zenkevich & Drugov, ), abietic acids (Azemard et al, ; Rontani et al, ), pectic oligosaccharides from artichoke (Sabater et al, ), lignans (Boldizsár, et al, ), vitamin B6 (Richter, et al, ) and polysaccharides from the Chinese medicinal herb Anemarrhena asphodeloides Bunge (Xia et al, ). Spectra of these compounds are mainly formed by α‐cleavages or cleavages and/or rearrangements of rings and do not present significant additional information on the general fragmentation of TMS derivatives discussed above.…”

Section: Trimethylsilyl Derivativesmentioning

confidence: 99%

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Harvey

Vouros

2019

Mass Spectrometry Reviews

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This review describes the mass spectral fragmentation of trimethylsilyl (TMS) and related alkylsilyl derivatives used for preparing samples for analysis, mainly by combined gas chromatography and mass spectrometry (GC/MS). The review is divided into three sections. The first section is concerned with the TMS derivatives themselves and describes fragmentation of derivatized alcohols, thiols, amines, ketones, carboxylic acids and bifunctional compounds such as hydroxy‐ and amino‐acids, halo acids and hydroxy ethers. More complex compounds such as glycerides, sphingolipids, carbohydrates, organic phosphates, phosphonates, steroids, vitamin D, cannabinoids, and prostaglandins are discussed next. The second section describes intermolecular reactions of siliconium ions such as the TMS cation and the third section discusses other alkylsilyl derivatives. Among these latter compounds are di‐ and trialkyl‐silyl derivatives, various substituted‐alkyldimethylsilyl derivatives such as the tert‐butyldimethylsilyl ethers, cyclic silyl derivatives, alkoxysilyl derivatives, and 3‐pyridylmethyldimethylsilyl esters used for double bond location in fatty acid spectra. © 2019 Wiley Periodicals, Inc. Mass Spec Rev 0000:1–107, 2019

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Section: Trimethylsilyl Derivativesmentioning

confidence: 99%

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Harvey

Vouros

2019

Mass Spectrometry Reviews

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“…Moreover, a more useful evaluation system can be applied in TCM by effectively reflecting the integrity and comprehensive function of Chinese medicinal ingredients. Many methods are used in the study of fingerprint, including chromatography methods [12], spectroscopic methods, and other methods, such as high performance liquid chromatography (HPLC) [13], UV spectroscopy (UV) [14], IR spectrum (IR) [15], and mass spectrometry (MS) [16]. Among them, HPLC is mostly applied to fingerprint analysis.…”

Section: Introductionmentioning

confidence: 99%

Fingerprint Analysis of Cnidium monnieri (L.) Cusson by High-Speed Counter-Current Chromatography

Gao

Zhu

et al. 2019

Molecules

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Cnidium monnieri (L.) Cusson is a popular Traditional Chinese Medicine (TCM) with a variety of bioactivities. However, there are some problems that have affected the development of Cnidium monnieri (L.) Cusson. At present, many methods have been reported for the analysis of coumarins in Cnidium monnieri (L.) Cusson. However, the quality control of coumarins in Cnidium monnieri (L.) Cusson by high-speed counter-current chromatography (HSCCC) has not been reported. In this study, analytical high-speed counter-current chromatography (HSCCC) was successfully used for fingerprint of Cnidium monnieri (L.) Cusson with a two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water at 4:6:6.5:3.5 (v/v). The UV wavelength was set at 254 nm. Six coumarin compounds with high biological activity were selected as indicator compounds for the quality control. The HSCCC fingerprint of the Cnidium monnieri (L.) Cusson was successfully established and there were some differences according to the results of the fingerprint analysis. The present results demonstrate that HSCCC is an established and efficient technique for the fingerprint analysis of Cnidium monnieri (L.) Cusson and can be used to control the quality of Cnidium monnieri (L.) Cusson. In brief, HSCCC is a useful technology for the fingerprint analytical method for TCM.

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“…MS‐based methods include matrix‐assisted laser desorption ionization MS, 20 electrospray ionization‐mass spectrometry, 21 and tandem MS 22 to reveal the structure of a certain glycans. Chromatographic methods, including gas chromatography 23 and high‐performance liquid chromatography, 24 are also efficient tools to determine glycan structure. When interference of isomeric structures is a possibility, these methods are more likely to be used in combination with LC‐MS, 19,24 a technique that combines the physical separation capabilities of LC with the mass analysis capabilities of MS. Detaching a glycan from a biological sample is typically the first step of structural characterization.…”

Section: Methods To Characterize Glycosylationmentioning

confidence: 99%

The “sugar‐coated bullets” of cancer: Tumor‐derived exosome surface glycosylation from basic knowledge to applications

Lin

Zhou

Tan

2020

Clinical & Translational Med

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Scientific interest in exosomes has exploded in recent decades. In 1990 only three articles were published on exosomes, while over 1,700 have already been published halfway into 2020. 1 While researchers have shown much interest in exosomes since being discovered in 1981, an appreciation of the potential role of glycans in exosome structure and function has emerged only recently. Glycosylation is one of the most common post-translational modification, which functions in many physiological and pathological aspects of cellular function. Many components of exosomes are heavily glycosylated including proteins, lipids, among others. Thus, glycosylation undoubtedly has a great impact on exosome biosynthesis and function. Despite the importance of glycosylation in exosomes and the recent recognition of them as biomarkers for not only malignancies but also other system dysfunction and disease, the characterization of exosome glycans remains understudied. In this review, we discuss glycosylation patterns of exosomes derived from various tissues, their biological features, and potential for various clinical applications. We highlight state-of-the-art knowledge about the fine structure of exosomes, which will allow researchers to reconstruct them by surface modification. These efforts will likely lead to novel disease-related biomarker discovery, purification tagging, and targeted drug transfer for clinical applications in the future.

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Gas chromatography–mass spectrometry-based trimethylsilyl-alditol derivatives for quantitation and fingerprint analysis of Anemarrhena asphodeloides Bunge polysaccharides

Cited by 45 publications

References 36 publications

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Fingerprint Analysis of Cnidium monnieri (L.) Cusson by High-Speed Counter-Current Chromatography

The “sugar‐coated bullets” of cancer: Tumor‐derived exosome surface glycosylation from basic knowledge to applications

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