Gas chromatographic — Mass spectrometric quantitation of 16,16-dimethyl-trans-Δ2-PGE1

A randomised study of misoprostol and gemeprost in combination with mifepristone for induction of abortion in the second trimester of pregnancy

“…Side effects of prostaglandins are mainly due to their effect on the smooth muscles and are dose related. Following vaginal administration of misoprostol, the plasma concentration remains raised for longer but the peak levels are lower than after oral administration and the pharmacokinetics are similar to vaginal gemeprost 18,19 . The duration of treatment was similar in both groups and the incidence of side effects such as pain, diarrhoea and vomiting was not different.…”

A randomised study of misoprostol and gemeprost in combination with mifepristone for induction of abortion in the second trimester of pregnancy

“…Side effects of prostaglandins are mainly due to their effect on the smooth muscles and are dose related. Following vaginal administration of misoprostol, the plasma concentration remains raised for longer but the peak levels are lower than after oral administration and the pharmacokinetics are similar to vaginal gemeprost 18,19 . The duration of treatment was similar in both groups and the incidence of side effects such as pain, diarrhoea and vomiting was not different.…”

Isolation of plasma components by double antibody precipitation and filtration: application to the chromatographic determination of arbaprostil [(15R)-15-methylprostaglandin E2]

“…This is especially true of prostaglandins (PG's) because they are typically present in nanogram per milliliter concentrations or less and are physicochemically similar to naturally occurring compounds present in higher concentration. Extraction methods for PG's based on liquid/liquid (1,2) or solid phase (2)(3)(4) partitioning are relatively nonselective and the extracts are frequently unsuitable for direct analysis, even by highly specific gas chromatography/mass spectrometric (GC/MS) quantitation methods (5)(6)(7)(8)(9). The necessity of purifying extracts before chromatographic analysis makes the analytical procedures more complex, laborious, and time-consuming to develop.…”