A randomised study of misoprostol and gemeprost in combination with mifepristone for induction of abortion in the second trimester of pregnancy

Bartley, Julia; Baird, D. T.

doi:10.1046/j.1471-0528.2002.01462.x

Cited by 63 publications

(18 citation statements)

References 22 publications

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“…In our study, mean age of patients in group 1 was 25.77 ± 4.62 years, which was similar to other studies. 7,8,9 Mean parity of group 1 was 2.13 ± 1.34, which corresponds to that of study by Neha Agarwal et al in 2014. 10 In our study, mean gestational age was 15.5 ± 2.85 and 15.72 ± 2.75 in group 1 and group 2, respectively.…”

Section: Discussionsupporting

confidence: 87%

A Comparative Study of Mifepristone and Misoprostol Versus Misoprostol Alone in Mid Trimester Termination of Pregnancy

Soren¹,

Dash²

2018

jebmh

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BACKGROUNDTermination of pregnancy in second trimester continues to be a challenge in developing countries especially in rural areas. There is an exponential rise in complications of abortion along with advancing gestational age. The search is on for an ideal method of abortion, which is reliable, safe and cheap. This study was conducted in M.K.C.G. Medical College and Hospital, Berhampur, from November 2015 to October 2017 with the aim of finding an effective method to induce second trimester abortion within reasonable time with fewer complications.

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Section: Discussionsupporting

confidence: 87%

A Comparative Study of Mifepristone and Misoprostol Versus Misoprostol Alone in Mid Trimester Termination of Pregnancy

Soren¹,

Dash²

2018

jebmh

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“…Mifepristone, a progesterone receptor antagonist, is effective in shortening the induction to abortion interval when used in combination with prostaglandins, but it is expensive. 1,2 Recent reports have demonstrated that misoprostol, a synthetic prostaglandin E 1 analogue, is a promising alternative prostaglandins. 3 -7 It is stable at room temperature and widely available, but its adverse effects, such as fever, nausea, vomiting and abdominal pain, are still of concern.…”

Section: Introductionmentioning

confidence: 99%

A randomised controlled trial of 6 and 12 hourly administration of vaginal misoprostol for second trimester pregnancy termination

Herabutya

Chanrachakul

Punyavachira

2005

BJOG

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Objective To compare the effectiveness of vaginal misoprostol administered 6 or 12 hourly for second trimester pregnancy termination. Design A randomised controlled trial. Setting University teaching hospital. Sample Two hundred and seventy‐nine pregnant women at gestations between 14 and 26 weeks undergoing pregnancy termination. Methods Women were randomised to receive 600‐μg misoprostol tablets vaginally either every 6 hours or every 12 hours until abortion occurred. Main outcome measures Induction–abortion interval, success rate within 24 and 48 hours and adverse effects. Results There was no significant difference in the median induction to abortion interval 6 hours (16 hours) and 12 hours (16 hours; P= 0.80). The total dose of misoprostol was higher in the 6‐hour group (1800 vs 1200 μg). The cumulative abortion rates within 24 hours were 74% and 67% and within 48 hours 94% and 92%, in the 6‐ and 12‐hour groups, respectively. Fever was more common in the 6‐hour group (53%) versus the 12‐hour group (31%; P < 0.001). The incidence of nausea, vomiting, diarrhoea, severe bleeding and abdominal pain were similar. Conclusions Misoprostol (600 μg) administered at 12‐hour intervals was associated with fewer adverse effects and was as effective as a 6‐hour interval.

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“…[8][9][10] They have also been compared with other different dosage protocols of misoprostol which has got significant value regarding the usage of Mifepristone as cervical ripening and abortificient ability.…”

Section: Discussionmentioning

confidence: 99%

A prospective comparative study to evaluate the efficacy and safety of mifepristone with misoprostol over misoprostol alone in induction of labour

Mandade

Bangal

2016

Int J Reprod Contracept Obstet Gynecol

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A randomised study of misoprostol and gemeprost in combination with mifepristone for induction of abortion in the second trimester of pregnancy

Abstract: Two hundred milligrammes of mifepristone followed 36-48 hours later by either vaginal gemeprost or misoprostol is a highly effective way of inducing abortion in the second trimester of pregnancy.

Cited by 63 publications

References 22 publications

A Comparative Study of Mifepristone and Misoprostol Versus Misoprostol Alone in Mid Trimester Termination of Pregnancy

A Comparative Study of Mifepristone and Misoprostol Versus Misoprostol Alone in Mid Trimester Termination of Pregnancy

A randomised controlled trial of 6 and 12 hourly administration of vaginal misoprostol for second trimester pregnancy termination

A prospective comparative study to evaluate the efficacy and safety of mifepristone with misoprostol over misoprostol alone in induction of labour

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