Gas chromatographic enantiomer separation on single and mixed cyclodextrin derivative chiral stationary phases

Abstract

SummaryCapillary gas chromatographic enantiomer separation of some polar compounds, including a-phenylethylamine, styrene oxide, pyrethroid insecticides and other carboxylates, was investigated on modified cyclodextrin (CD) chiral stationary phases. The chiral stationary phases studied included permethylated fl-CD (PMBCD), hep-(DNTBCD), the mixture of PMBCD and DBBBCD, and the mixture of PMBCD and DNTBCD. On the mixed chiral stationary phases containing the mixtures ofderivatized cyctodextrins, enantiomer separation was improved significantly for some compounds as compared to the single cyclodextrin derivative chiral stationary phases, and synergistic effects were observed for some compounds on the mixed cyclodextrin derivative chiral stationary phases.

Improved gas chromatographic stereodifferentiation of chiral main constituents from different essential oils using a mixture of chiral stationary phases

“…1,2 Nie et al 1 reported on the enantioseparation of chiral pyrethroid insecticides using a mixture of heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin, with either heptakis (2,6-…”

A mixed stationary phase containing two versatile cyclodextrin-based selectors for the simultaneous gas chromatographic enantioseparation of racemic alkanes and racemic α-amino acid derivatives☆

“…Subsequently, in a number of papers the use of mixed binary CD selector systems for the enantioseparation of different classes of chiral compounds has been described [29][30][31][32][33][34][35]. In the present work, a comprehensive enantioselectivity spectrum toward racemic unfunctionalized alkanes and racemic derivatized ␣-amino acids as well as to other classes of racemic compounds such as lactones, diols, secondary alcohols, ketones and terpenes has been realized by diluting the two versatile CD selectors depicted in Fig.…”

Stereoisomeric Separation of Derivatized 2-alkanols Using Gas Chromatography-Mass Spectrometry: Sex Pheromone Precursors Found in Pine Sawfly Species

“…Although, a larger cyclodextrin ring does not automatically mean improved separation when the size of the analyte is increased (Juvancz and Petersson 1996). Another alternative is to use a column with a mixture of different chiral phases, which has shown to significantly improve separation of some esters compared to single cyclodextrin derivative phases (Nie et al 2000). The combination of two different columns in the tandem techniques of heart cutting or two-dimensional GC (GC Ã GC) could also be a solution that needs to be investigated further (McNair and Miller 2009;Wang et al 2010).…”