Gas chromatographic determination of penicillins

Formation of trimethylsilyl derivatives of tetracyclines for separation and quantitation by gas-liquid chromatography

“…Gas-liquid chromatography (GLC) has been applied as a sensitive method for the separation and quantitation of various antibiotics and their isomers and derivatives (20)(21)(22)(23)(24)(25)(26). This report is, to the best of our knowledge, the first to describe trimethylsilylation of tetracyclines and their separation and quantitation by GLC.…”

Gas chromatography

“…Finally, a few interesting and noval applications include the GC determination of penicillins (389), the identification and quantitative determination of microgram amounts of "street heroin" (212, 625), hallucinogens (779), and the drugs in opium extract (64), a GC/MS reference data system with MS base peak index for 133 drugs of abuse (259), and a rapid £<3 hr) analytical method for emergency drug analyses (796). The analysis of the C15-Cse n-alkanes in air particulate matter (377), the identification of spilled residual fuel oils (464), and the characterization of organic components in municipal water supplies (490) are representative of the many applications of GC to pollution studies.…”

Separation and Determination of Five Penicillins by Reversed Phase HPLC

“…with the respective formulas given in Many procedures for the determination of penicillins were reported in literature, applicable to electrophoresis (Z), microbiological analysis (3), paper chromatography (PC) (4), thin layer chromatography (TLC) (5.6), gas-liquid chromatography (GLC) (7,8), and high performance liquid chromatography (HPLC) (9,10,11).…”