Gas Chromatographic Analysis of Amine Mixtures in Drug Formulations

GLC Analysis of Multicomponent Suppository Formulations

“…In the present report, data are presented regarding the GLC assay of suppositories containing: (Type 1) aminophenazone in association with sodium sulfadimethoxine (not determined) ; (Type 11) chlorpheniramine maleate, d-propoxyphene hydrochloride, lidocaine, and caffeine in association with paracetamol and calcium urea acetylsalicylate (not determined) ; and (Type 111) aminophenazone, phenacetin, chlorpheniramine maleate, fenalamide l, caffeine, and sodium benzoate. Although GLC determination of these compounds in other pharmaceutical forms as components of different associations (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) and/or as single drugs (16-26) was already reported, the procedures described could not be utilized in the present case.…”