“…This effect was postulated to be due to the reduced biosynthesis of fatty acids as NADPH, required for the process, was utilised for the metabolism of the oil. Garlic ameliorated the signs associated with Cu defi ciency, although hepatic lipogenesis was not affected (Fields et al 1992 ). Administration of garlic reduced the activity of the lipogenic enzyme glucose-6-phosphate dehydrogenase only in Cu-adequate rats.…”