Garlic oil as a modulating agent for oxidative stress and neurotoxicity induced by sodium nitrite in male albino rats

Hassan, Hanaa A.; Hafez, Hani S.; Zeghebar, Fawzia E.

doi:10.1016/j.fct.2010.05.001

Cited by 39 publications

(29 citation statements)

References 52 publications

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“…Oral sodium nitrite in rats produces hepatotoxicity (Hassan et al, 2010). As shown in Table 2, sodium nitrite caused significant increases in serum ALT and ALP activities and bilirubin concentration as compared with the control group (p50.05).…”

Section: Effect Of Cod Liver Oil On Liver Functionmentioning

confidence: 93%

“…Effect of cod liver oil on oxidative stress Hassan et al (2010) reported previously that sodium nitrite exerts oxidative stress and retrograde the endogenous antioxidant system. However, we found significant increases in the serum and hepatic levels of malondialdehyde (MDA), hydrogen peroxide and superoxide anion as compared with the control group (p50.05).…”

Section: Effect Of Cod Liver Oil On Sodium Nitrite-induced Morphologimentioning

confidence: 99%

“…The doses and time course of experiments used for sodium nitrite were in the range of those used in other studies (Hassan et al, 2010). In addition, the dose was determined after appropriate preliminary experiments.…”

Section: Animals and Their Treatment Outlinesmentioning

confidence: 99%

“…Recent understanding of the molecular events of increased levels of sodium nitirte has focused on oxidative stress in different body organs (Hassan et al, 2010). Less attention has been given to nutritional treatment using cod liver oil.…”

Section: Introductionmentioning

confidence: 99%

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Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats

Salama

Abbas

Darweish³

et al. 2013

Pharmaceutical Biology

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Context: Exposure to high levels of nitrites for a prolonged time have adverse health effects on several organs especially the liver due to oxidative properties. Meanwhile, cod liver oil has been reported to ameliorate organ dysfunction in animal models that involve oxidative stress. Objective: Examine the impact of dietary cod liver oil on sodium nitrite-induced liver damage. Materials and methods: Thirty-two adult male Sprague-Dawely rats were daily treated with sodium nitrite (80 mg/kg) in presence or absence of cod liver oil (5 ml/kg). Morphological changes were assessed in liver sections. Oxidative stress and antioxidant markers were measured in serum and liver homogenates. Liver samples were used for measurements of MCP-1, DNA fragmentation and mitochondrial function. Results: The hepatoprotective effect of cod liver oil was proved by significant reduction of elevated liver enzymes and normal appearance of hepatocytes. Cod liver oil significantly reduced hepatic malondialdehyde, hydrogen peroxide and superoxide anion (224.3 AE 18.9 nmol/g, 59.3 AE 5.1 and 62.5 AE 5.1 mmol/g, respectively) compared with sodium nitrite (332.5 AE 25.5 nmol/g, 83.1 AE 8.1 and 93.9 AE 6.5 mmol/g, respectively). Cod liver oil restored hepatic cytochrome c oxidase activity after 38% reduction by sodium nitrite. Furthermore, cod liver oil significantly reduced hepatic MCP-1 (79.8 pg/mg) and DNA fragmentation (13.8%) compared with sodium nitrite (168.7 pg/mg and 41.3%, respectively). Discussion and conclusion: Cod liver oil ameliorates sodium nitrite induced hepatic impairment through several mechanisms including attenuation of oxidative stress, blocking MCP-1, reactivation of mitochondrial function and reduction of DNA fragmentation.

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Section: Effect Of Cod Liver Oil On Liver Functionmentioning

confidence: 93%

Section: Effect Of Cod Liver Oil On Sodium Nitrite-induced Morphologimentioning

confidence: 99%

Section: Animals and Their Treatment Outlinesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats

Salama

Abbas

Darweish³

et al. 2013

Pharmaceutical Biology

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“…It also inhibits lipid peroxidation and reduces I/R injury by inhibiting the oxidative modification of low-density lipoprotein. In addition, Allium sativum prevents DNA damage by lowering the levels of oxidative stress markers (Hassan et al, 2010). Anim-Nyame et al (2004) shows that Allium sativum (garlic oil) also reduces precapillary vessel resistance of the microvascular bed by increasing IL-6 secretion from the vascular endothelium during a hypoxic state.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Allium sativum’s Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model

et al. 2018

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SUMMARY:We aimed to evaluate the effects of detorsion and Allium sativum (garlic oil) treatment on the ovarian reserve in an ovarian torsion model. Ovarian torsion may lead to loss of ovarian tissue and infertility. It is an experimental rat study that was carried out on 16 sets of ovaries each, one for treatment group and a control group. In the control group, the procedure involved only the surgically opening and closing the abdomen. Bilateral adnexal torsion/detorsion was performed after a 3-hour ischemia period for the detorsion-only group. The detorsion + Allium sativum group received a 5 ml/kg dose of Allium sativum intraperitoneally, 2 hours before surgery. After the second surgery, removed ovarian samples were evaluated for follicle counts, damage scores and other parameters. Primordial, preantral, small antral and large antral follicle counts were significantly higher in the detorsion + Allium sativum group. Degeneration, congestion, hemorrhage ,inflammation and total damage scores were significantly elevated in the detorsion only group compared to those for the detorsion + Allium sativum group. Finally, there was a significant correlation between AMH alterations and postoperative, preantral follicle count (p<0.05). As a conclusion detorsion + Allium sativum treatment may be effective in protecting the ovarian reserve after torsion.

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Garlic

Charles¹

2012

Antioxidant Properties of Spices, Herbs and Other Sources

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Garlic oil as a modulating agent for oxidative stress and neurotoxicity induced by sodium nitrite in male albino rats

Cited by 39 publications

References 52 publications

Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats

Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats

Investigation of Allium sativum’s Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model

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Garlic oil as a modulating agent for oxidative stress and neurotoxicity induced by sodium nitrite in male albino rats

Cited by 39 publications

References 52 publications

Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats

Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats

Investigation of Allium sativum&#8217;s Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model

Garlic

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Product

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Investigation of Allium sativum’s Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model