Garlic in dermatology

Pazyar, Nader; Feily, Amir

doi:10.4081/dr.2011.e4

Cited by 36 publications

(20 citation statements)

References 32 publications

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“…The protective effect of the H 2 S-releasing PFM from oxidative damage, which was observed in the non-direct growth on the membranes, opens new perspectives in their application as biomedical devices that could be used inside or outside the body, such as non-implantable devices/patches for wound dressing, implantable material like vascular grafts, heart valves and implants for reducing the ischemic damages and improving the patient health and medical conditions. Moreover, the enhancement of the wound healing induced by Allium sativum L. via re-epithelialization and neovascularization has been already demonstrated [ 52 , 53 ].…”

Section: Resultsmentioning

confidence: 99%

Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress

Cacciotti

Ciocci

Giovanni

et al. 2018

IJMS

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The design of biomaterial platforms able to release bioactive molecules is mandatory in tissue repair and regenerative medicine. In this context, electrospinning is a user-friendly, versatile and low-cost technique, able to process different kinds of materials in micro- and nano-fibers with a large surface area-to-volume ratio for an optimal release of gaseous signaling molecules. Recently, the antioxidant and anti-inflammatory properties of the endogenous gasotramsmitter hydrogen sulfide (H2S), as well as its ability to stimulate relevant biochemical processes on the growth of mesenchymal stem cells (MSC), have been investigated. Therefore, in this work, new poly(lactic) acid fibrous membranes (PFM), doped and functionalized with H2S slow-releasing donors extracted from garlic, were synthetized. These innovative H2S-releasing mats were characterized for their morphological, thermal, mechanical, and biological properties. Their antimicrobial activity and effects on the in vitro human cardiac MSC growth, either in the presence or in the absence of oxidative stress, were here assessed. On the basis of the results here presented, these new H2S-releasing PFM could represent promising and low-cost scaffolds or patches for biomedical applications in tissue repair.

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Section: Resultsmentioning

confidence: 99%

Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress

Cacciotti

Ciocci

Giovanni

et al. 2018

IJMS

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“…Garlic extract induces the lymphocytes proliferation and macrophage phagocytosis, stimulates the infiltration of macrophages and lymphocytes in transplanted tumors, induces splenic hypertrophy, stimulates release of interleukin‐2, tumor necrosis factor alpha and interferon‐gamma, and enhances natural killer cell and lymphokine‐activated killer cell activity. Apart from these beneficial effects, garlic has also been found to cause various cutaneous adverse effects like irritant contact dermatitis, allergic contact dermatitis, protein contact dermatitis, zosteriform dermatitis, and contact urticarial 16 …”

Section: Discussionmentioning

confidence: 99%

Home remedies in different pediatric dermatoses: An observational study

Gupta¹,

Bhargava

2020

Dermatologic Therapy

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Traditional medicinal systems are widely practiced in the Indian subcontinent for a wide variety of diseases. We aimed to identify the various home remedies used by people to treat numerous pediatric dermatoses. It was an observational study carried out over 18 months in which 150 children attending our clinics were recruited. A detailed history regarding the various indigenous preparations used was taken from caregivers and noted in a proforma. A total of 150 children (M:F-89:61) aged between 4 months to 18 years were included. Atopic dermatitis and eczema (n = 28) were the most common dermatoses whereas the most common home remedies used for these either solo or in combination were coconut oil (13), olive oil (11), mustard oil (7), aloevera gel (6), ghee (6), curd (4), and honey (2). Acne was the second most common dermatoses (n = 22), products used for acne were Fuller's earth, aloevera gel, turmeric, gram flour, mustard oil, lime and sandalwood paste. Other dermatoses treated by indigenous products included impetigo and other bacterial infections, seborrheic dermatitis, dermatophytoses, verruca, molluscum, hypopigmentary disorders, etc. In Indian setup, home remedies are commonly used by the caregivers before visiting a dermatologist to treat various pediatric dermatoses.

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“…The protective effect of the H2S-releasing PFM from oxidative damage, which was observed in the non-direct growth on the membranes, opens new perspectives in their application as biomedical devices that could be used inside or outside the body, such as non-implantable devices/patches for wound dressing, implantable material like vascular grafts, heart valves and implants for reducing the ischemic damages and improving the health and medical condition of the patient. Moreover, the enhancing of the wound healing induced by Allium sativum L. via re-epithelialization and neovascularization has been already demonstrated [56,57].…”

Section: Gaos Doped Pfm Improve the Cmsc Proliferationmentioning

confidence: 99%

Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating the Human Stem Cells Proliferation and Viability Under Oxidative Stress.

Cacciotti¹,

Ciocci²,

Giovanni³

et al. 2018

Preprint

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The design of biomaterial platforms able to release bioactive molecules is mandatory in tissue repair and regenerative medicine. In this context, electrospinning is a user-friendly, versatile and low-cost technique, able to process different kinds of materials in micro- and nano-fibers with a large surface area-to-volume ratio for an optimal release of gaseous signalling molecules. Recently, the antioxidant and anti-inflammatory properties of the endogenous gasotramsmitter hydrogen sulfide (H2S), as well as its ability to stimulate relevant biochemical processes on the growth of mesenchymal stem cells (MSC), have been investigated. Therefore, in this work, new poly(lactic) acid fibrous membranes (PFM), doped and functionalized with H2S slow-releasing donors extracted from garlic, were synthetized. These innovative H2S-releasing mats were characterized for their morphological, thermal, mechanical and biological properties. Their antimicrobial activity and effects on the in vitro human cardiac MSC growth, either in the presence or in the absence of oxidative stress, were here assessed. On the basis of the results here presented, these new H2S-releasing PFM could represent promising and low-cost scaffolds or patches for biomedical applications in tissue repair.

show abstract

Garlic in dermatology

Cited by 36 publications

References 32 publications

Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress

Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress

Home remedies in different pediatric dermatoses: An observational study

Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating the Human Stem Cells Proliferation and Viability Under Oxidative Stress.

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