Garlic and Resveratrol Attenuate Diabetic Complications, Loss of β-Cells, Pancreatic and Hepatic Oxidative Stress in Streptozotocin-Induced Diabetic Rats

Abstract

The study was aimed at finding the effect of garlic and resveratrol on loss of β-cells and diabetic complication in streptozotocin (STZ)-induced Type-I diabetic rats. Rats were injected with single dose STZ (50 mg/kg, i.p.) for induction of type 1 diabetes (Dia) and compared with control group. Rats from third (Dia+Gar), fourth (Dia+Resv), and fifth (Dia+Met) groups were fed raw garlic homogenate (250 mg/kg/day), resveratrol (25 mg/kg/day), and metformin (500 mg/kg/day) orally, respectively, for a period of 4 weeks. Diabetic group had decreased serum insulin and hydrogen sulfide levels along with increased blood glucose and glycated hemoglobin, triglyceride, uric acid, and nitric oxide levels. Significant (p < 0.05) increase in pancreatic and hepatic TBARS, conjugated dienes, nitric oxide, and AGE level and significant (p < 0.05) decrease in SOD, catalase, H2S, GSH level were observed in diabetic group. Administration of garlic, resveratrol, and metformin significantly (p < 0.05) normalized most of the altered metabolic and oxidative stress parameters as well as histopathological changes. Administration of garlic, resveratrol, and metformin in diabetic rat decreases pancreatic β-cell damage and hepatic injury. Our data concluded that administration of garlic showed more promising effect in terms of reducing oxidative stress and pathological changes when compared to resveratrol and metformin groups.

Effects of <i>Vernonia cinerea</i> on reproductive performance in streptozotocin-induced diabetic rats

“…A previous study suggested that flavonoids exerted the antidiabetic effects via action on various molecular targets, including regulation of glucose metabolism in hepatocytes, increasing glucose uptake by the skeletal muscle and white adipose tissue [4]. Another study revealed that phytochemical compounds, such as garlic acid and resveratrol, decreased pancreatic β-cell damage in STZ-induced diabetic rats and suggested that the antidiabetic mechanism might invlove stimulation of insulin secretion or release of bound insulin [15]. However, VC supplementation in diabetic rats did not alleviate the body weight and food consumption.…”

Ethnopharmacological survey of medicinal plants with hallucinogenic effect and plants used against pain, inflammatory diseases, diabetes and urinary lithiasis in Zagora “Morocco”.

“…Indeed, the fenugreek seeds [34], Marrubium vulgare [35], N. sativa [36], A. sativum [37], Carum carvi, and Ziziphus lotus [38,39] shows an antidiabetic effects in streptozotocininduced diabetic in rat and alloxan-induced diabetes in mice. Khan et al demonstrated in vitro that P. dactylifera seeds extract inhibit α-glucosidase and α-amylase level [40].…”

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

“…Arteriosclerosis, management of diabetes mellitus, asthma, deafness, leprosy, bronchial congestion, fevers, worms, and liver gall bladder trouble [180] Antidiabetic, hepatoprotective, antimicrobial, and antihyperlipidemic activities [181] Annona muricata L.…”