2020
DOI: 10.1155/2020/3529081
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Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

Abstract: The burden of neoplastic diseases is a significant global health challenge accounting for thousands of deaths. In Uganda, about 32,617 cancer cases were reported in 2018, accompanied by 21,829 deaths. In a view to identify some potential anticancer plant candidates for possible drug development, the current study was designed to compile the inventory of plants with reported anticancer activity used in rural Uganda and the evidences supporting their use in cancer therapy. An electronic survey in multidisciplina… Show more

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Cited by 75 publications
(61 citation statements)
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“…In vitro anticancer study: The in vitro anti-proliferative tests were carried out as described previously [15], using aliquots of the cell lines used therein. Briefly, HeLa, MDA-MB-231 and MDA-MB-468, MCF7, and 184B5 and MCF 10A cell lines were purchased from ATCC.…”
Section: Cell Lines and Cell Culturementioning
confidence: 99%
See 1 more Smart Citation
“…In vitro anticancer study: The in vitro anti-proliferative tests were carried out as described previously [15], using aliquots of the cell lines used therein. Briefly, HeLa, MDA-MB-231 and MDA-MB-468, MCF7, and 184B5 and MCF 10A cell lines were purchased from ATCC.…”
Section: Cell Lines and Cell Culturementioning
confidence: 99%
“…Natural products have been discovered as rich and powerful sources for anticancer and antimalarial therapies, including vinblastine from Catharanthus roseus [15,16], paclitaxel or taxol from Taxus brevifolia [17,18], curcurmin from Curcuma longa [19] and artemisinin from Artemisia annua [13,20,21]. Moreover, synthetic compounds were identified to be effective on both cancer cells and Plasmodium, such as gold-or iron-metallocenes [22][23][24].…”
Section: Introductionmentioning
confidence: 99%
“…Ajuga remota Benth (different parts), for example, are used to relieve toothache, severe stomachache, oedema associated with protein-calorie malnutrition disorders in infants when breast-feeding is terminated, pneumonia, and liver problems [52,104,105]. Such plants are used across different ethnic communities for managing malaria and can be a justification of their efficacy in malaria treatment [19]. Table 3 shows the list of some of the antimalarial plants used in Kenya with reports of toxicity/safety, antimalarial, and antiplasmodial activity evaluation.…”
Section: Other Ethnomedicinal Uses Of Antimalarial Plants Used Inmentioning
confidence: 99%
“…C.A.Sm. [ 44 , 45 ]. It should be pointed that some cytotoxic compounds such as Epivernodalol, a sesquiterpene lactone elemanolide-type, present in Vernonia amydalina Delile used by chimpanzees, also existed in Vernonia lasiopus O.Hoffm.…”
Section: Zoopharmacognosymentioning
confidence: 99%
“…employed by humans [ 27 , 46 ]. Besides, the possible common anticancer compounds among A. coriaria , A. gummifera (both used by humans), and A. gradibracteata used by chimpanzees might be oleanane-type triterpene saponins [ 28 , 38 , 43 , 44 , 45 ].…”
Section: Zoopharmacognosymentioning
confidence: 99%