Garlic (Allium sativum): diet based therapy of 21st century–a review

Suleria, Hafiz Ansar Rasul; Butt, Masood Sadiq; Khalid, Nauman; Sultan, Saira; Raza, Ali; Aleem, Muhammad; Abbas, Munawar

doi:10.1016/s2222-1808(14)60782-9

Cited by 109 publications

(70 citation statements)

References 68 publications

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“…Garlic ( Allium sativum ) and its compounds have been used for centuries for their health benefits against conditions such as joint inflammation, constipation, infectious diseases, and parasitic infestations . Several experimental and human trials have shown that garlic and garlic oil have potent antioxidant, anti‐inflammatory, immunomodulatory, hepatoprotective, and antimicrobial properties . Different compounds may be responsible for these activities, being propyl‐propane thiosulfonate (PTSO) one of them.…”

Section: Introductionmentioning

confidence: 99%

The Immunomodulatory Properties of Propyl‐Propane Thiosulfonate Contribute to its Intestinal Anti‐Inflammatory Effect in Experimental Colitis

Vezza

Algieri

Garrido-Mesa

et al. 2019

Molecular Nutrition Food Res

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Scope Propyl‐propane thiosulfonate (PTSO) is a component isolated from garlic (Allium sativum) with antioxidant, anti‐inflammatory, immunomodulatory, and antimicrobial properties. In consequence, PTSO can be a potential candidate for the treatment of inflammatory bowel diseases. Methods and results The anti‐inflammatory effects of PTSO are studied in two mice models of colitis: 2,4‐dinitrobenzene sulfonic acid (DNBS) (PTSO doses: 0.01–10 mg kg–1) and dextran sodium sulfate (DSS) (PTSO doses: 0.01–0.1 mg kg–1). The immunomodulatory effects of PTSO (0.1–25 µm) are also shown in vitro in Caco‐2 and THP‐1 cells, reducing the production of pro‐inflammatory mediators and downregulating mitogen‐activated protein kinases (MAPKs) signaling pathways. This compound displays beneficial effects in both models of mouse colitis by reducing the expression of different pro‐inflammatory mediators and improving the intestinal epithelial barrier integrity. Moreover, PTSO ameliorates the altered gut microbiota composition observed in DSS colitic mice. Conclusion PTSO exerts intestinal anti‐inflammatory activity in experimental colitis in mice. This anti‐inflammatory activity can be associated with the immunomodulatory properties of PTSO through the regulation of the activity of cells involved in the inflammatory response. Furthermore, PTSO is able to restore the intestinal epithelial barrier function and to ameliorate the intestinal microbiota homeostasis, thus supporting its future development in human IBD.

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Section: Introductionmentioning

confidence: 99%

The Immunomodulatory Properties of Propyl‐Propane Thiosulfonate Contribute to its Intestinal Anti‐Inflammatory Effect in Experimental Colitis

Vezza

Algieri

Garrido-Mesa

et al. 2019

Molecular Nutrition Food Res

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“…Allium plants contain powerful antioxidants, sulfur, and numerous phenolic compounds that have attracted much attention in the food industry (Beretta et al, ; Sultan, Buttxs, Qayyum, & Suleria, ). For many years, they have been used to prevent and treat certain diseases such as diabetes, arthritis, colds and flu, cough, headache, hemorrhage, asthma, atherosclerosis, and inflammatory diseases (H. A. R. Suleria, Butt, Khalid, et al, ; Suleria, Butt, Anjum, Arshad, & Khalid, ; Zeng et al, ). It has recently been noted that these vegetables, in addition to the conventional antibacterial, antifungal, antiviral, antiprotozoal, and antiworm effects, showed extensive in vitro and in vivo antiproliferative, antimotility, and cytotoxic potentials against cancer cells (Abdelrahman, Mahmoud, El‐Sayed, Tanaka, & Tran, ; Chu et al, ; Kazemi, Zolfaghari, Keivanloo Shahrestanaki, & Sadeghi Dinani, ; Kocić‐Tanackov et al, ; Packia Lekshmi, Viveka, Jeeva, & Raja Brindha, ; Sharifi‐Rad et al, ).…”

Section: Introductionmentioning

confidence: 99%

Allium vegetables for possible future of cancer treatment

Asemani

Zamani

Bayat

et al. 2019

Phytotherapy Research

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Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerous diseases. The phytochemical analysis of various Allium genus members showed that, to date, 16 species have proved potential anticancer properties due to the accumulation of various sulfur and organic compounds like S‐allyl mercaptocysteine, quercetin, flavonoids, and ajoene. These compounds with various mechanisms such as hindering cell cycle, inhibiting signaling pathways, inducing apoptosis, and antioxidant activity interfere with diverse stages of formation, growth, differentiation, and metastasis of cancer cells. Similar to garlic and onion, other species have exhibited anticancer activities, so that active natural molecules extracted from them might serve as possible anticancer agents. Therefore, evaluating the main ingredients and studying their anticancer mechanisms are of great importance. In this review, we aim to summarize the available data on anticancer mechanisms of 16 species of Allium genus and their major compounds to assist further researches on the treatment and prevention of cancers.

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“…Garlic has been reported to exhibit extensive biological activities (Butt et al 2009;Santhosha et al 2013;Suleria et al 2015), including antioxidant (Capasso 2013), antifatigue (Morihara et al 2007), anticancer (Nicastro et al 2015), and antimicrobial (Lanzotti et al 2014) activities. Garlic may also have a positive role in immunonutrition (Nantz et al 2012) and help prevent cardiovascular diseases (Castro et al 2010;Rahman 2007a).…”

Section: Introductionmentioning

confidence: 99%

An LC-MS/MS-SRM Method for Simultaneous Quantification of Four Representative Organosulfur Compounds in Garlic Products

Zhu

Kakino²,

Nogami

et al. 2016

Food Anal. Methods

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The quantitative analysis of organosulfur compounds is important for the quality control of various garlic products along with studying their molecular functionality and nutraceutical properties. In this study, a liquid chromatography-tandem mass spectrometry-selected reaction monitoring (LC-MS/MS-SRM) method with electrospray ionization detection was developed and validated for the rapid, simultaneous quantification of four representative organosulfur compounds in garlic: alliin, S-allyl-L-cysteine, γ-glutamyl-S-allyl-L-cysteine, and allicin. Stable SRM transitions were achieved for these compounds under optimized conditions, and the linear range extended from 1 to 2000 ng/ mL. The limits of detection and quantification ranged from 0.003 to 0.058 ng/mL and from 0.01 to 0.19 ng/mL, respectively. Excellent recovery and reproducibility at different spiking levels were achieved. The method was successfully applied to the simultaneous quantification of organosulfur compounds in fresh garlic samples. This highly selective and sensitive LC-MS/MS-SRM method is expected to be a useful tool for studying molecular functionality and the quality control of garlic products.

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Garlic (Allium sativum): diet based therapy of 21st century–a review

Cited by 109 publications

References 68 publications

The Immunomodulatory Properties of Propyl‐Propane Thiosulfonate Contribute to its Intestinal Anti‐Inflammatory Effect in Experimental Colitis

The Immunomodulatory Properties of Propyl‐Propane Thiosulfonate Contribute to its Intestinal Anti‐Inflammatory Effect in Experimental Colitis

Allium vegetables for possible future of cancer treatment

An LC-MS/MS-SRM Method for Simultaneous Quantification of Four Representative Organosulfur Compounds in Garlic Products

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