Garcina Kola neuroprotective effects on the prefrontal cortex cyto-architecture of MDMA-induced neuroinflammation in male Wistar rats model

Afees, Olanrewaju John; Okoro, Iheanyichukwu; Oladele, Owolabi Joshua; Yinka, Olatunji Sunday; Taiye, Adelodun Stephen; Oluseyi, Fabiyi Sunday

doi:10.1016/j.phyplu.2021.100174

Cited by 1 publication

(2 citation statements)

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“…as food to animal and humans for their growth and development [7]. Beyond nutritional role there are other functions that plant plays in helping humans and animals survive in their environment [8]. Plant secondary metabolites such as phytochemicals are used to fight pathogens [9].…”

Section: Organic and Medicinal Chemistry International Journalmentioning

confidence: 99%

“…The compounds (Table 4a) were camphene (monoterpenes) at a retention time of 5.33 with a peak area of 43.2 which is known for its analgesic and anti-inflammatory property [7]. Eucalyptol (1,8-cineole) with a retention time of 14.67 and peak area of 7.6 is used as an antioxidant, anti-cancer and analgesic in drug formulation [8]. Trans-caryophyllene at Organic and Medicinal Chemistry International Journal retention time 18.161 with a peak area of 2.7 has an anti-microbial and anti-bacterial activity [44].…”

Section: Gc-msmentioning

confidence: 99%

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Analysis of Phytochemical Constituents and Antioxidant Potential of Bitter Kola Leaf Extract towards Bioactive Food, Nutrition and Health Resources

Edo¹

2022

OMCIJ

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Plants are important to life, beyond nutritional role there are other functions that plant plays in helping humans and animals survive in their environment. This study focused on identifying the phytochemicals, bioactive compounds present in bitter kola leave, their in-vitro antioxidant activities and compared with n-hexane, ethanol and aqueous solvent to identify effective solvent for extraction of these phytochemicals in relation to food, health and nutritional benefits. The FTIR and GC-MS assessment of the extracts showed the existence of bioactive compounds. The outcome showed the detection of tannin, phenol, alkaloid, flavonoid, protein and carbohydrate in all leaf extracts, with ethanol having the highest concentration of these phytochemicals (p<0.05). The in-vitro free radical scavenging properties of bitter kola leaf extracts against 1, 1-diphenyl-2-picryl hydrazyl showed that the n-hexane leaf extract recorded the highest inhibitory activities when compared to both n-hexane and ethanol extracts (p<0.05) across all concentrations. However, all extracts showed increase in inhibitory activities with increasing concentrations. When compared to both n-hexane and ethanol leaf extracts, the ferric reducing antioxidant capacity of Garcinia kola leaf extracts rose with concentrations, with the aqueous leaf extract having the strongest reducing characteristics from 5mg/ml to 7mg/ml (p<0.05). The bioactive compounds present in bitter kola leaves makes it consumable and suitable in the treatment of different diseases such as bacterial infection, cancer, diabetics and inflammation because its level of effectiveness is confirmed in traditional medicine.

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Section: Organic and Medicinal Chemistry International Journalmentioning

confidence: 99%