Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities–focused research

Franzen, Sanne; Nuytemans, Karen; Bourdage, Renelle; Caramelli, Paulo; Ellajosyula, Ratnavalli; Finger, Elizabeth; Illán‐Gala, Ignacio; Loi, Samantha M; Morhardt, Darby; Pijnenburg, Yolande A.L.; Rascovsky, Katya; Williams, Monique; Yokoyama, Jennifer S.; Alladi, Suvarna; Ayhan, Yavuz; Broce, Iris; Castro‐Suárez, Sheila; Coleman, Kristy; Souza, Leonardo Cruz de; Dacks, Penny A.; Boer, Sterre C.M. de; Deleon, Jessica; Dodge, Shana; Grasso, Stephanie; Gupta, Veer Bala; Gupta, Vivek Kumar; Ghoshal, Nupur; Kamath, Vidyulata; Kumfor, Fiona; Matías‐Guiu, Jordi A.; Narme, Pauline; Nielsen, T. Rune; Okhuevbie, Daniel; Piña‐Escudero, Stefanie Danielle; García, Ricardo Ortiz; Scarioni, Marta; Slachevsky, Andrea; Suárez‐González, Aida; Tee, Boon Lead; Tsoy, Elena; Ulugut, Hulya; Babulal, Ganesh M.; Onyike, Chiadi U.

doi:10.1002/alz.13129

Cited by 6 publications

(1 citation statement)

References 267 publications

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“…The present analysis could only attribute differences between the Latam and HIC samples to their geographical origin. To address this non-specificty, future studies should replicate our findings using better characterized samples, including data on environmental exposure, social determinants of health, socioeconomic status, risk factors and genetic diversity, which are factors implicated in the disparity between Latam and HIC [70][71][72][73][74][75].…”

Section: Effect Of Demographic and Clinical Variables On Loss Of Loca...mentioning

confidence: 96%

Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition

Moguilner,

Herzog,

Perl

et al. 2024

Alz Res Therapy

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Background The hypothesis of decreased neural inhibition in dementia has been sparsely studied in functional magnetic resonance imaging (fMRI) data across patients with different dementia subtypes, and the role of social and demographic heterogeneities on this hypothesis remains to be addressed. Methods We inferred regional inhibition by fitting a biophysical whole-brain model (dynamic mean field model with realistic inter-areal connectivity) to fMRI data from 414 participants, including patients with Alzheimer’s disease, behavioral variant frontotemporal dementia, and controls. We then investigated the effect of disease condition, and demographic and clinical variables on the local inhibitory feedback, a variable related to the maintenance of balanced neural excitation/inhibition. Results Decreased local inhibitory feedback was inferred from the biophysical modeling results in dementia patients, specific to brain areas presenting neurodegeneration. This loss of local inhibition correlated positively with years with disease, and showed differences regarding the gender and geographical origin of the patients. The model correctly reproduced known disease-related changes in functional connectivity. Conclusions Results suggest a critical link between abnormal neural and circuit-level excitability levels, the loss of grey matter observed in dementia, and the reorganization of functional connectivity, while highlighting the sensitivity of the underlying biophysical mechanism to demographic and clinical heterogeneities in the patient population.

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Section: Effect Of Demographic and Clinical Variables On Loss Of Loca...mentioning

confidence: 96%

Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition

Moguilner,

Herzog,

Perl

et al. 2024

Alz Res Therapy

View full text Add to dashboard Cite

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Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities–focused research

Franzen

Nuytemans

Bourdage

et al. 2023

Alzheimer's & Dementia

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Frontotemporal dementia (FTD) is one of the leading causes of dementia before age 65 and often manifests as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). FTD's exact clinical presentation varies by culture, language, education, social norms, and other socioeconomic factors; current research and clinical practice, however, is mainly based on studies conducted in North America and Western Europe. Changes in diagnostic criteria and procedures as well as new or adapted cognitive tests are likely needed to take into consideration global diversity. This perspective paper by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment examines how increasing global diversity impacts the clinical presentation, screening, assessment, and diagnosis of FTD and its treatment and care. It subsequently provides recommendations to address immediate needs to advance global FTD research and clinical practice.

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Interpreter-mediated neuropsychological assessment: Clinical considerations and recommendations from the European Consortium on Cross-Cultural Neuropsychology (ECCroN)

Nielsen,

Franzen,

Watermeyer

et al. 2024

The Clinical Neuropsychologist

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Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities–focused research

Cited by 6 publications

References 267 publications

Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition

Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition

Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities–focused research

Interpreter-mediated neuropsychological assessment: Clinical considerations and recommendations from the European Consortium on Cross-Cultural Neuropsychology (ECCroN)

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