Gap analysis of nickel bioaccessibility and bioavailability in different food matrices and its impact on the nickel exposure assessment

Babaahmadifooladi, Mehrnoosh; Jacxsens, Liesbeth; Wiele, Tom Van de; Laing, Gijs Du

doi:10.1016/j.foodres.2019.108866

Cited by 29 publications

(16 citation statements)

References 82 publications

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“…In accordance with the scientific literature, high mean levels of nickel were reported for 'Legumes, nuts and oilseeds' (~2,000 lg/kg), certain types of chocolate (cocoa) products (3,800 lg/kg), and 'Cocoa beans and cocoa products' (9,500 lg/kg) (EFSA CONTAM Panel, 2015). Babaahmadifooladi et al (2020b) reviewed the scientific literature for data on the occurrence of nickel, including the EFSA Opinion from 2015 and concluded that the foods with high nickel content are mostly of plant-based origin, e.g. legumes, soya-based products and nuts, compared with foods of animal origin such as meat, fish, and honey, which have lower nickel concentrations.…”

Section: Previously Reported Occurrence Data In the Open Literaturementioning

confidence: 99%

“…The CONTAM Panel noted that lower or similar exposure to nickel is expected in breastfed infants as compared to non-breastfeeding infants. Babaahmadifooladi et al (2020b) reviewed the scientific literature for data on the dietary exposure to nickel. However, no recent studies conducted in Europe were included and so this review is not further discussed in this Opinion.…”

Section: Previously Reported Dietary Exposurementioning

confidence: 99%

“…Babaahmadifooladi et al. (2020b) reviewed the scientific literature for data on the occurrence of nickel, including the EFSA Opinion from 2015 and concluded that the foods with high nickel content are mostly of plant‐based origin, e.g. legumes, soya‐based products and nuts, compared with foods of animal origin such as meat, fish, and honey, which have lower nickel concentrations.…”

Section: Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance and newly available scientific information. More than 47,000 analytical results on the occurrence of nickel were used for calculating chronic and acute dietary exposure. An increased incidence of postimplantation loss in rats was identified as the critical effect for the risk characterisation of chronic oral exposure and a BMDL 10 of 1.3 mg Ni/kg body weight (bw) per day was selected as the reference point for the establishment of a tolerable daily intake (TDI) of 13 lg/kg bw. Eczematous flare-up reactions in the skin elicited in nickel-sensitised humans, a condition known as systemic contact dermatitis, was identified as the critical effect for the risk characterisation of acute oral exposure. A BMDL could not be derived, and therefore, the lowest-observed-adverse-effect-level of 4.3 lg Ni/kg bw was selected as the reference point. The margin of exposure (MOE) approach was applied and an MOE of 30 or higher was considered as being indicative of a low health concern. The mean lower bound (LB)/upper bound (UB) chronic dietary exposure was below or at the level of the TDI. The 95th percentile LB/UB chronic dietary exposure was below the TDI in adolescents and in all adult age groups, but generally exceeded the TDI in toddlers and in other children, as well as in infants in some surveys. This may raise a health concern in these young age groups. The MOE values for the mean UB acute dietary exposure and for the 95th percentile UB raises a health concern for nickel-sensitised individuals. The MOE values for an acute scenario regarding consumption of a glass of water on an empty stomach do not raise a health concern.

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Section: Previously Reported Occurrence Data In the Open Literaturementioning

confidence: 99%

Section: Previously Reported Dietary Exposurementioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

View full text Add to dashboard Cite

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“…Here we report some of the main foods belonging to specific categories. To be noted is the overlap between Ni-rich foods and foods with high FODMAP content, as well as the overlap between foods high in FODMAPs and lactose content [10,[15][16][17][18][19]].…”

Section: Patientsmentioning

confidence: 99%

“…Patients affected by Ni ACM show a low-grade intestinal inflammation with a local adaptive response to Ni-containing foods: this mucositis seems to be characterized by increased lymphocyte trafficking (type IV immune response) [12,13]. Ni ACM diagnosis is currently based on a Ni oral mucosa patch test (omPT), which has already proved good sensitivity and specificity [13], and a low-Ni diet (LNiD) can be thus suggested in this condition in order to significantly reduce both Ni-related gastrointestinal and extraintestinal symptoms [14][15][16][17][18][19]. Figure 1 shows the main foods with the highest Ni content, and it is easy to observe that many of them (e.g., corn) are consumed in large quantities by CD patients on a proper and strict GFD [15,16].…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of a Low-Nickel Diet on Relapsing IBS-Like and Extraintestinal Symptoms of Celiac Patients during a Proper Gluten-Free Diet: Nickel Allergic Contact Mucositis in Suspected Non-Responsive Celiac Disease

et al. 2020

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Background and Aim: Nickel (Ni)-rich foods can induce allergic contact mucositis (ACM) with irritable bowel syndrome (IBS)-like symptoms in predisposed subjects. Ni ACM has a high prevalence (>30%) in the general population and can be diagnosed by a Ni oral mucosa patch test (omPT). Many celiac disease (CD) patients on a gluten-free diet (GFD) often show a recrudescence of gastrointestinal and extraintestinal symptoms, although serological and histological remission has been achieved. Since a GFD often results in higher loads of ingested alimentary Ni (e.g., corn), we hypothesized that it would lead to a consequent intestinal sensitization to Ni in predisposed subjects. We wanted to (1) study Ni ACM prevalence in still symptomatic CD patients on a GFD and (2) study the effects of a low-Ni diet (LNiD) on their recurrent symptoms. Material and Methods: We recruited 102 consecutive CD patients (74 female, 28 male; age range 18–65 years, mean age 42.3 ± 7.4) on a GFD since at least 12 months, in current serological and histological remission (Marsh–Oberhuber type 0–I) who complained of relapsing gastrointestinal and/or extraintestinal symptoms. Inclusion criteria: presence of at least three gastrointestinal symptoms with a score ≥5 on the modified Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. Exclusion criteria: IgE-mediated food allergy; history of past or current cancer; inflammatory bowel diseases; infectious diseases including Helicobacter pylori; lactose intolerance. All patients enrolled underwent Ni omPT and followed a LNiD for 3 months. A 24 symptoms questionnaire (GSRS modified according to the Salerno Experts’ Criteria, with 15 gastrointestinal and 9 extraintestinal symptoms) was administered at T0 (free diet), T1 (GFD, CD remission), T2 (recurrence of symptoms despite GFD), and T3 (GFD + LNiD) for comparisons. Comparisons were performed using Wilcoxon signed-rank test. RESULTS: Twenty patients (all female, age range 23–65 years, mean age 39.1 ± 2.9) out of 102 (19.6%) were finally included. All 20 patients enrolled (100%) showed positive Ni omPT, confirming an Ni ACM diagnosis. A correct GFD (T0 vs. T1) induced the improvement of 19 out of the total 24 (79.2%) symptoms, and 14 out of 24 (58.3%) were statistically significant (p-value < 0.0083 according to Bonferroni correction). Prolonged GFD (T1 vs. T2) revealed the worsening of 20 out of the total 24 (83.3%) symptoms, and 10 out of 24 (41.7%) were statistically significant. LNiD (T2 vs. T3) determined an improvement of 20 out of the total 24 (83.4%) symptoms, and in 10 out of 24 (41.7%) symptoms the improvement was statistically significant. Conclusions: Our data suggest that the recrudescence of gastrointestinal and extraintestinal symptoms observed in CD subjects during GFD may be due to the increase in alimentary Ni intake, once gluten contamination and persisting villous atrophy are excluded. Ni overload can induce Ni ACM, which can be diagnosed by a specific Ni omPT. Improvement of symptoms occurs after a proper LNiD. These encouraging data should be confirmed with larger studies.

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Nickel and Its Compounds

Buxton,

Verpaele,

Oller

2023

Patty's Toxicology

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Nickel (Ni) is a naturally occurring element in the transition metals of the periodic table. Nickel is naturally present in the Earth's crust, rocks, soil, plants, and water; nickel is essential to some microorganisms and plants. Thus, nickel is naturally found in a variety of crops, foodstuffs, and animals. Nickel and its compounds are used extensively in applications like batteries, stainless steel, and medical devices. Thus, natural and anthropogenic exposures to nickel and its compounds are ubiquitous. The human toxicities associated with excess exposure to nickel include nickel allergic contact dermatitis, respiratory cancer, noncancer respiratory toxicity, and reproductive effects. The bioavailable nickel +2 ion is reported to drive the toxicities associated with nickel. In this book chapter on nickel and its compounds, we explore the physical and chemical properties, production and use, occupational and nonoccupational exposures, toxicokinetics, toxicities, workplace exposure assessment and surveillance, and last but not least, environmental exposure assessment and surveillance of nickel and nickel compounds.

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Gap analysis of nickel bioaccessibility and bioavailability in different food matrices and its impact on the nickel exposure assessment

Cited by 29 publications

References 82 publications

Update of the risk assessment of nickel in food and drinking water

Update of the risk assessment of nickel in food and drinking water

Beneficial Effects of a Low-Nickel Diet on Relapsing IBS-Like and Extraintestinal Symptoms of Celiac Patients during a Proper Gluten-Free Diet: Nickel Allergic Contact Mucositis in Suspected Non-Responsive Celiac Disease

Nickel and Its Compounds

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