Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon

Guo, Cuiling; Guo, Dandan; Liu, Fang; Sang, Tingting; Wu, Jianjun; Guo, Chengjie; Wang, Yujie; Wang, Ying; Chen, Chaojie; Chen, Jiajun; Chen, Rong; Wang, Xingya

doi:10.1016/j.carbpol.2021.118231

Cited by 202 publications

(132 citation statements)

References 97 publications

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“…MyD88 is involved in protective inflammatory responses that regulate intestinal bacteria and the homeostasis of intestinal epithelial cells [125]. Ganoderma lucidum polysaccharides reduced the abundance of Lachnoclostridium, Oscillibacter, Desulfovibrio, Alipipes, and Parasutterella, and they inhibited the expression of MyD88, thereby alleviating DSS-induced colitis in mice [75]. Astragalus polysaccharides established intestinal microbiota balance by regulating the relative abundance of Lactobacillus, Bifidobacteria, and Enterobacteriaceae, and they inhibited the activation of the MyD88 signaling pathway so as to alleviate intestinal inflammation [126].…”

Section: Effect On Intestinal Immunity and Inflammatory Responsesmentioning

confidence: 99%

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

et al. 2022

Foods

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The incidence of inflammatory bowel disease (IBD) has increased in recent years. Considering the potential side effects of conventional drugs, safe and efficient treatment methods for IBD are required urgently. Natural polysaccharides (NPs) have attracted considerable attention as potential therapeutic agents for IBD owing to their high efficiency, low toxicity, and wide range of biological activities. Intestinal microbiota and their fermentative products, mainly short-chain fatty acids (SCFAs), are thought to mediate the effect of NPs in IBDs. This review explores the beneficial effects of NPs on IBD, with a special focus on the role of intestinal microbes. Intestinal microbiota exert alleviation effects via various mechanisms, such as increasing the intestinal immunity, anti-inflammatory activities, and intestinal barrier protection via microbiota-dependent and microbiota-independent strategies. The aim of this paper was to document evidence of NP–intestinal microbiota-associated IBD prevention, which would be helpful for guidance in the treatment and management of IBD.

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Section: Effect On Intestinal Immunity and Inflammatory Responsesmentioning

confidence: 99%

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

et al. 2022

Foods

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“…In this study, WQP enhanced the expression levels of the tight junction proteins Occludin and Claudin-1, which play a protective role in the intestinal barrier. Similarly, G. lucidum polysaccharides were shown to have beneficial effects on gut barrier functions by improving the protein expression of the tight junction proteins Occludin and Claudin-1 [ 39 ]. The mitogen-activated protein kinase family (MAPK) is a conserved serine protein kinase family in the cytoplasm that can transmit stress signals and promote cell proliferation and can mediate the signal transduction of various cytokines [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Panax quinquefolius Polysaccharides Ameliorate Antibiotic-Associated Diarrhoea Induced by Lincomycin Hydrochloride in Rats via the MAPK Signaling Pathways

Ren

Lin

et al. 2022

Journal of Immunology Research

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American ginseng (Panax quinquefolius L.) is an herbal medicine with polysaccharides as its important active ingredient. The purpose of this research was to identify the effects of the polysaccharides of P. quinquefolius (WQP) on rats with antibiotic-associated diarrhoea (AAD) induced by lincomycin hydrochloride. WQP was primarily composed of galacturonic acid, glucose, galactose, and arabinose. The yield, total sugar content, uronic acid content, and protein content were 6.71%, 85.2%, 31.9%, and 2.1%, respectively. WQP reduced the infiltration of inflammatory cells into the ileum and colon, reduced the IL-1β, IL-6, IL-17A, and TNF-α levels, increased the levels of IL-4 and IL-10 in colon tissues, improved the production of acetate and propionate, regulated the gut microbiota diversity and composition, improved the relative richness of Lactobacillus and Bacteroides, and reduced the relative richness of Blautia and Coprococcus. The results indicated that WQP can enhance the recovery of the intestinal structure in rats, reduce inflammatory cytokine levels, improve short-chain fatty acid (SCFA) levels, promote recovery of the gut microbiota and intestinal mucosal barrier, and alleviate antibiotic-related side effects such as diarrhoea and microbiota dysbiosis caused by lincomycin hydrochloride. We found that WQP can protect the intestinal barrier by increasing Occludin and Claudin-1 expression. In addition, WQP inhibited the MAPK inflammatory signaling pathway to improve the inflammatory status. This study provides a foundation for the treatment of natural polysaccharides to reduce antibiotic-related side effects.

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“…GLP was capable of repressing azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis and colorectal carcinogenesis in mice ( Guo C. et al, 2021 ). Mechanistically, GLP reversed gut microbiota dysbiosis caused by AOM/DSS.…”

Section: The Antitumor Activities Of Polysaccharides From G...mentioning

confidence: 99%

Research Progress on the Anticancer Activities and Mechanisms of Polysaccharides From Ganoderma

Wang

2022

Front. Pharmacol.

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Cancer ranks as a primary reason for death worldwide. Conventional anticancer therapies can cause severe side effects, and thus natural products may be promising drug candidates for cancer therapy. Accumulating evidence has verified the prominent anticancer properties of Ganoderma polysaccharides, suggesting that Ganoderma polysaccharides may be effective chemopreventive agents of natural origin. Based on their abilities to prevent cancer development by regulating the DNA damage response, cancer cell proliferation, apoptosis, host immunity, gut microbiota and therapeutic sensitivity, there has been increasing interest in elucidating the clinical implication of Ganoderma polysaccharides in cancer therapy. In this review, we summarize recent findings pertaining to the roles of bioactive polysaccharides from Ganoderma in cancer pathogenesis, discuss the multifarious mechanisms involved and propose future directions for research. A more sophisticated understanding of the anticancer benefits of Ganoderma polysaccharides will be helpful for improving current treatments and developing novel therapeutic interventions for human malignancies.

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Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon

Cited by 202 publications

References 97 publications

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

Panax quinquefolius Polysaccharides Ameliorate Antibiotic-Associated Diarrhoea Induced by Lincomycin Hydrochloride in Rats via the MAPK Signaling Pathways

Research Progress on the Anticancer Activities and Mechanisms of Polysaccharides From Ganoderma

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