Ganoderma lucidum and its pharmaceutically active compounds

Boh, Bojana; Berovič, Marin; Zhang, Jingsong; Lin, Zhibin

doi:10.1016/s1387-2656(07)13010-6

Cited by 476 publications

(328 citation statements)

References 87 publications

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“…Some common edible mushrooms like G. lucidum or L. edodes (Popović et al 2013;Ferreira et al 2014;Stojković et al 2014) are subject of intense studies for quite some time, so the current focus is on isolated substances or crude extracts derived from lesser-known edible mushrooms (Boh et al 2007;Altobelli 2011). They are the potential source of diverse biomolecules with nutritional and/or medicinal properties (Alves et al 2012).…”

Section: Research Highlightsmentioning

confidence: 99%

Nutritional value, chemical composition, antioxidant activity and enrichment of cream cheese with chestnut mushroom Agrocybe aegerita (Brig.) Sing

et al. 2015

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Section: Research Highlightsmentioning

confidence: 99%

Nutritional value, chemical composition, antioxidant activity and enrichment of cream cheese with chestnut mushroom Agrocybe aegerita (Brig.) Sing

et al. 2015

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“…This observation can be attributed to (1) inter-specific differences in uptake of elements from overgrown substrate, (2) different contents of elements in the overgrown substrates, or (3) both. It has been widely demonstrated that mushrooms, including Ganoderma spp., can be grown on different substrates, not only in terms of their type but also origin and quality [25][26][27][28]. Moreover, different species of the Ganoderma genus may require different conditions for growth and cultivation [29].…”

Section: Discussionmentioning

confidence: 99%

Comparison of multielemental composition of Polish and Chinese mushrooms (Ganoderma spp.)

Siwulski

Rzymski

Niedzielski

et al. 2017

Eur Food Res Technol

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“…Since ancient times, Ganoderma has been widely used as a popular herbal medicine for the promotion of health (11). Numerous previous studies examined the immunomodulatory activities of Ganoderma (12,13).…”

Section: Discussionmentioning

confidence: 99%

Antitumor effects and mechanisms of Ganoderma extracts and spores oil

Chen

Li³

et al. 2016

Oncology Letters

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Abstract. Ganoderma lucidum is a popular herbal medicine used in China to promote health. Modern studies have disclosed that the active ingredients of Ganoderma can exhibit several effects, including antitumor effects and immunomodulation. The present study evaluated the antitumor effects of self-prepared Ganoderma extracts and spores oil, and investigated the possible underlying mechanisms by observing the effects of the extracts and oil on topoisomerases and the cell cycle. The results showed that Ganoderma extracts and spores oil presented dose-dependent inhibitory effects on tumor cells. The half maximal inhibitory concentration (IC 50 ) values of Ganoderma extracts on HL60, K562 and SGC-7901 cells for 24 h were 0.44, 0.39 and 0.90 mg/ml, respectively; for Ganoderma spores oil, the IC 50 values were 1.13, 2.27 and 6.29 mg/ml, respectively. In the in vivo study, the inhibitory rates of Ganoderma extracts (4 g/kg/d, intragastrically) on S180 and H22 cells were 39.1 and 44.6%, respectively, and for Ganoderma spores oil (1.2 g/kg/d, intragastrically) the inhibitory rates were 30.9 and 44.9%, respectively. Ganoderma extracts and spores oil inhibited the activities of topoisomerase I and II. Ganoderma spores oil was shown block the cell cycle at the transition between the G1 and S phases and induce a marked decrease in cyclin D1 levels in K562 cells, with no significant change in cyclin E level. These results suggest that the Ganoderma extracts and spores oil possessed antitumor effects in the in vitro and in vivo studies. The antitumor mechanisms of the extracts and spores oil were associated with inhibitory effects on topoisomerase I and II activities, and for Ganoderma spores oil, the antitumor effects may also be associated with decreased cyclin D1 levels, thus inducing G1 arrest in the cell cycle.

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Ganoderma lucidum and its pharmaceutically active compounds

Cited by 476 publications

References 87 publications

Nutritional value, chemical composition, antioxidant activity and enrichment of cream cheese with chestnut mushroom Agrocybe aegerita (Brig.) Sing

Nutritional value, chemical composition, antioxidant activity and enrichment of cream cheese with chestnut mushroom Agrocybe aegerita (Brig.) Sing

Comparison of multielemental composition of Polish and Chinese mushrooms (Ganoderma spp.)

Antitumor effects and mechanisms of Ganoderma extracts and spores oil

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