Ganglion Cell–Inner Plexiform Layer and Peripapillary Retinal Nerve Fiber Layer Thicknesses in Age-Related Macular Degeneration

Lee, Eun Kyoung; Yu, Hyeong Gon

doi:10.1167/iovs.15-17013

Cited by 69 publications

(101 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have indicated the possibility of changes in the internal layer in the early stages of AMD [21] as well as in the GCL and GCC [34,35] . To understand the structures or locations in formations/configurations of interest, we manually evaluated GCL and GCC thickness in subjects with early/intermediate AMD at 12 locations in the horizontal meridian by SD-OCT, and we discovered thickness values close to the ones presented in other studies.…”

Section: Discussionmentioning

confidence: 99%

“…It would be useful to study the GCC's susceptibility to early/intermediate AMD [35] . This complex may be a good marker for typical disorganized synaptic architectural changes in the early/late stages of AMD [34] . The presence of drusen may cause severe morphological changes in multiple retinal layers due to mechanical pressure [34] .…”

Section: Discussionmentioning

confidence: 99%

“…This complex may be a good marker for typical disorganized synaptic architectural changes in the early/late stages of AMD [34] . The presence of drusen may cause severe morphological changes in multiple retinal layers due to mechanical pressure [34] . Changes in the GCC may be attributed to vascular abnormalities in the inner retinal layers [34] or at the choroid level [35] .…”

Section: Discussionmentioning

confidence: 99%

“…Changes in the GCC may be attributed to vascular abnormalities in the inner retinal layers [34] or at the choroid level [35] . This, in association with the normal outer retinal degeneration in AMD as well as inflammatory mediators [35,43] , may decrease the input to the inner retina, creating lesions in the outer layers which may favor transneuronal degeneration [34] .…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Ganglion Cell Complex in Early and Intermediate Age-Related Macular Degeneration: Evidence by SD-OCT Manual Segmentation

Camacho

Dutra-Medeiros²,

Paris³

2017

Ophthalmologica

View full text Add to dashboard Cite

Purpose: To evaluate ganglion cell layer (GCL) and ganglion cell complex (GCC) thickness manually by spectral-domain optical coherence tomography in subjects with early and intermediate age-related macular degeneration (AMD) in 12 locations on the horizontal meridian. Methods: A total of 450 eyes (specifically, 246 eyes classified as having early/intermediate AMD plus 204 control eyes) were studied. Mann-Whitney U and Kruskal-Wallis tests were used to compare values between the healthy controls and the AMD group and also between the subgroups under study. Diagnostic performance was also compared calculating the areas under the receiver operating characteristic curve. Results: The manual layer segmentation showed clear boundaries between the GCL and the GCC. It was in the temporal GCC that more changes were found. Conclusions: The GCC, especially in the temporal region, allowed the discrimination of differences between various subgroups that have faint variations as well as between early AMD and the first signs of aging.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Ganglion Cell Complex in Early and Intermediate Age-Related Macular Degeneration: Evidence by SD-OCT Manual Segmentation

Camacho

Dutra-Medeiros²,

Paris³

2017

Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…Lee and Yu [20] found that the GCL–IPL thickness decreased after vitrectomy with ILM peeling. In our study, we found that both the thickness and volume of the ganglion layers decreased in sectors 1, 2, and 5.…”

Section: Discussionmentioning

confidence: 99%

Postoperative changes in the retinal thickness and volume after vitrectomy for epiretinal membrane and internal limiting membrane peeling

Won

Kim²,

Park³

2017

Medicine

View full text Add to dashboard Cite

The aim of the study was to investigate the thickness and volume profiles of each retinal layer in postoperative patients with epiretinal membranes.Twenty-four patients who underwent pars plana vitrectomy with internal limiting membrane (ILM) peeling for epiretinal membrane were included. The best corrected visual acuity, thickness, and volume were recorded from the medical records through a retrospective review. Spectral domain optical coherence tomography was used to measure the average thickness and volume of each retinal layer before surgery and 6 months postoperatively.All 24 patients were monitored for 60 months after surgery. In all Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, the thickness and volume of the retinal nerve fiber layer and the inner retinal layer decreased significantly. In contrast, the thickness and volume of the ganglion cell layer, inner nuclear layer, inner plexiform layer, and outer plexiform layer only decreased in some ETDRS subfields. Finally, there was no significant change in the thickness or volume of the outer nuclear layer (ONL), retinal pigment epithelium (RPE), and photoreceptor layers in all ETDRS subfields.The thickness and volume of the inner retina layer decreased significantly after pars plana vitrectomy using ILM peeling. However, there was no significant change in the thickness and volume of the outer retinal layers (ONL, RPE, and photoreceptor) after surgery.

show abstract

Strukturelle Endpunkte für Glaukomstudien

et al. 2018

View full text Add to dashboard Cite

show abstract

Ganglion Cell–Inner Plexiform Layer and Peripapillary Retinal Nerve Fiber Layer Thicknesses in Age-Related Macular Degeneration

Abstract: In eyes with dry AMD, mGCIPL and pRNFL thicknesses were lower than measurements in control eyes, and the average mGCIPL thickness was negatively correlated with the drusen area. However, the pattern of these changes differed from glaucomatous abnormalities.

Cited by 69 publications

References 28 publications

Ganglion Cell Complex in Early and Intermediate Age-Related Macular Degeneration: Evidence by SD-OCT Manual Segmentation

Ganglion Cell Complex in Early and Intermediate Age-Related Macular Degeneration: Evidence by SD-OCT Manual Segmentation

Postoperative changes in the retinal thickness and volume after vitrectomy for epiretinal membrane and internal limiting membrane peeling

Strukturelle Endpunkte für Glaukomstudien

Contact Info

Product

Resources

About