Gangliogliomas intracraneales. Revisión de una serie de 20 pacientes

Gelabert-González, Miguel; Amo, J.M. Santín; Algaba, A. Arcos; Garcia, R.; Bouzas, D. Castro; Cabana, L. Díaz; González, A. Prieto; Echabe, E. Aran; Dieguez, Francisco; Fernández, J. Villa; Allut, A. García

doi:10.1016/j.nrl.2010.09.014

Cited by 14 publications

(13 citation statements)

References 48 publications

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“…Temporal lobe involvement was in tight association with preoperative epileptic seizure in our study and it was supported by several other research. 8 , 9 Our inability to find most of the variables, especially tumor characteristics with preoperative epileptic seizure may due to limited number of sample size.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with preoperative and postoperative epileptic seizure in patients with cerebral ganglioglioma

Huang¹,

Li²,

Chen³

et al. 2014

Pak J Med Sci

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Objective: To explore the factors associated with preoperative epileptic seizure and surgical outcome in patients with cerebral gangliolioma (GG). Methods: A total of 31 consecutive patients with pathologically confirmed ganglioglioma and surgically treated from January 2003 to June 2011 in West China Hospital of Sichuan University were retrospectively reviewed. Clinical data, surgical procedure and follow-up information were collected and analyzed. Results: Nineteen patients presented with epileptic seizure, of which 63.2% were males. The mean age at epilepsy surgery and mean seizure duration were 25.6 years and 2.3 years respectively. Factors associated with preoperative epileptic seizure were supratentorial lesion and temporal lobe involvement (p=0.016 and 0.008). Intraoperative electrocorticography (ECoG) was applied in 8 out of 19 epilepsy patients. Eighteen achieved total tumor excision. After a mean follow up of 2.8 (1.3-6.3) years, 11 (68.8%, 11/16) achieved seizure free (Engel class I). Early surgery (seizure duration <3 years) was a significant predictor of favorable seizure outcome (p=0.013). None of the factors including seizure type, tumor location, neuroimaging characteristics and application of intraoperative ECoG or surgical strategy were found to be significantly associated with postoperative seizure outcome. Postoperative combination of AEDs was unnecessary for seizure control. Conclusions: Ganglioglioma with temporal lobe involvement usually associated with intractable epilepsy. Early surgical resection is strongly suggested to achieve favorable outcome. Intraoperative ECoG is not inevitable and simple lesionectomy is sufficient for satisfactory seizure control. Early accurate diagnosis of ganglioglioma should be established on comprehensive consideration and plays an important role in dealing with these patients.

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Section: Discussionmentioning

confidence: 99%

Factors associated with preoperative and postoperative epileptic seizure in patients with cerebral ganglioglioma

Huang¹,

Li²,

Chen³

et al. 2014

Pak J Med Sci

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“…[715–19212526] Its most frequent location is the temporal lobe, followed by frontal and parietal lobes, but it can develop elsewhere in the central nervous system, including diencephalic, brainstem, cerebellar, and spinal cord locations. [8151625] Immunohistochemical demonstration of GFAP is used to identify glial cells, which are usually negative to MAP-2 in GGs, whereas several neuronal markers like neurofilament protein, synaptophysin, NeuN, neuron specific enolase and MAP-2 are helpful in visualizing the neuronal portion. Also, S-100 protein and vimentin may be used to demonstrate glial elements.…”

Section: Discussionmentioning

confidence: 99%

“…Despite being useful, these markers cannot differentiate between normal and neoplastic cells. [81011151625]…”

Section: Discussionmentioning

confidence: 99%

“…[25681112151620212526] Its malignant changes are still less frequent, and if these happen, almost always the malignant component is the glial one, evolving toward glioblastoma. [256810111215–182021] There are only few cases in which the neuronal component exhibits malignant transformation. [235610121925] We present a case of a temporal GG and its malignant recurrence as a primitive neuroectodermal tumor (PNET).…”

Section: Introductionmentioning

confidence: 99%

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Epilepsy due to a temporal ganglioglioma and its subsequent malignant transformation into a primitive neuroectodermal tumor

Bendersky

Tedesco²,

Christiansen³

et al. 2012

Surg Neurol Int

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Background:Gangliogliomas (GGs) are rare brain tumors, and their malignant changes are still less frequent. In these cases, almost always the malignant component is the glial one. However, there are few cases in which the neuronal component exhibits malignant transformation.Case Description:We described a case of a 14-year-old male patient who started with seizures and 5 years later, its frequency was almost daily despite being treated with several antiepileptic drugs. Magnetic resonance imaging showed a nonenhancing lesion located at the right inferior temporal gyri. He underwent surgery, and the tumor was completely removed. Histological diagnosis was GG. He had no seizures anymore, but 3 years later, the tumor recurred as a giant heterogeneously enhancing space-occupying mass within the right temporal lobe. A second surgical resection was performed. Histological diagnosis was a primitive neuroectodermal tumor (PNET). One month and a half later, the tumor has recurred again. He and his family decided not to undergo another operation, so he was referred to the radiotherapy department.Conclusion:As in this patient, GGs may recur as a primitive neuroectodermal tumor, likely because both types of neoplasm form part of the same heterogeneous group of brain tumors which contains neuronal components, but on the other side of the malignancy spectrum.

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“…PLGGs affecting the cerebral cortex typically present with focal neurological manifestations such as seizures or behavioral changes. Seizures are particularly associated with temporal, frontal, or parietal localization and oligodendrogliomas, GGs, DNTs or AGs subtypes 63–67 . Tumors involving the hypothalamus manifest with endocrinopathies or the diencephalic syndrome 68–70 .…”

Section: Clinical Presentationmentioning

confidence: 99%