Gamma‐synuclein is a novel prognostic marker that promotes tumor cell migration in biliary tract carcinoma

Takemura, Yusuke; Ojima, Hidenori; Oshima, Go; Shinoda, Masahiro; Hasegawa, Yasushi; Kitago, Minoru; Yagi, Hiroshi; Abe, Yuta; Hori, Shutaro; Fujii-Nishimura, Yoko; Kubota, Naoto; Masuda, Yuki; Hibi, Taizo; Sakamoto, Michiie; Kitagawa, Yuko

doi:10.1002/cam4.4121

Cited by 9 publications

(5 citation statements)

References 51 publications

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“…Similar to optic nerve axotomy and elevated intraocular pressure-induced injury, the present finding supports that the loss of RGCs is associated with the downregulation of SNCG expression in the retina after optic nerve injuries [30]. The expression level of SNCG has been correlated with the progression of some cancers [31] and Alzheimer's disease [32], suggesting a role in the pathophysiology. Aggregated SNCG was found in the motor neurons of some amyotrophic lateral sclerosis (ALS) patients [33].…”

Section: Discussionsupporting

confidence: 83%

Differential Responses of Retinal Neurons and Glia Revealed via Proteomic Analysis on Primary and Secondary Retinal Ganglion Cell Degeneration

Kwong

Lee

Song

et al. 2023

IJMS

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To explore the temporal profile of retinal proteomes specific to primary and secondary retinal ganglion cell (RGC) loss. Unilateral partial optic nerve transection (pONT) was performed on the temporal side of the rat optic nerve. Temporal and nasal retinal samples were collected at 1, 4 and 8 weeks after pONT (n = 4 each) for non-biased profiling with a high-resolution hybrid quadrupole time-of-flight mass spectrometry running on label-free SWATHTM acquisition (SCIEX). An information-dependent acquisition ion library was generated using ProteinPilot 5.0 and OneOmics cloud bioinformatics. Combined proteome analysis detected 2531 proteins with a false discovery rate of <1%. Compared to the nasal retina, 10, 25 and 61 significantly regulated proteins were found in the temporal retina at 1, 4, and 8 weeks, respectively (p < 0.05, FC ≥ 1.4 or ≤0.7). Eight proteins (ALDH1A1, TRY10, GFAP, HBB-B1, ALB, CDC42, SNCG, NEFL) were differentially expressed for at least two time points. The expressions of ALDH1A1 and SNCG at nerve fibers were decreased along with axonal loss. Increased ALDH1A1 localization in the inner nuclear layer suggested stress response. Increased GFAP expression demonstrated regional reactivity of astrocytes and Muller cells. Meta-analysis of gene ontology showed a pronounced difference in endopeptidase and peptidase inhibitor activity. Temporal proteomic profiling demonstrates established and novel protein targets associated with RGC damage.

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Section: Discussionsupporting

confidence: 83%

Differential Responses of Retinal Neurons and Glia Revealed via Proteomic Analysis on Primary and Secondary Retinal Ganglion Cell Degeneration

Kwong

Lee

Song

et al. 2023

IJMS

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“…Through activating the PI3K/AKT signaling pathway, SNCG can promote ovarian cancer cell metastasis [21]. Furthermore, SNCG can also serve as a potential prognostic gene for biliary tract cancer [22]. While considering the role of SNCG in GC, it has been proved that SNCG relates to the cancer invasion depth and lymph node metastasis of gastric adenocarcinoma [23].…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of anoikis-associated gene SNCG as a prognostic biomarker in gastric cancer

Pan

Cheng

et al. 2023

Aging

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Anoikis is a newly discovered form of apoptosis that was originally identified in the extracellular matrix (ECM).Recent studies have reported that anoikis is central to cancer metastasis. Here, SNCG was identified as hub anoikis-associated gene in GC and associated with prognosis of patients with GC. To screen the hub anoikisassociated genes connected to GC, the database of Cancer Genome Atlas (TCGA) was employed. For further validating these identified genes, the Gene Expression Omnibus (GEO) dataset was applied, and Western blotting and quantitative Real-Time PCR were carried out. To identify hub genes, we conducted the analyses of univariate Cox regression, differential expression, and weighted gene co-expression network analysis (WGCNA). According to the identified hub genes, we constructed a model of prognosis. Following complex analysis, SNCG was finally identified as hub anoikis-associated gene in GC. Indeed, K-M and receiver operating characteristic analyses suggested that the expression patterns of SNCG can be used as prognostic factors for GC survival. The expression and survival trends of SNCG were verified in the validation cohort and in vitro experimental analyses. The analysis of immune cell infiltration showed that the infiltrated immune cells varied among patients with GC and gene SNCG. Furthermore, due to the significant association of the constructed risk signature with patient age and survival, this risk signature can be used to predict the prognosis of GC. We suggest that SNCG was served as hub anoikis-associated gene in GC. Meanwhile, SNCG may have prognostic potential for overall patient survival.

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“…During recent decades, several studies associated γS levels with poor outcome in endometrial adenocarcinoma [ 61 , 113 ], which correlates with a worse prognosis for uterine corpus endometrial carcinoma patients with high levels of SNCG transcripts ( Figure 4 ). It has also been proposed that γS could be a prognostic marker for tumor cell migration in biliary carcinomas [ 120 ].…”

Section: Synucleins As Cancer Biomarkersmentioning

confidence: 99%

Synuclein Proteins in Cancer Development and Progression

Zanotti,

Malizia,

Cesatti Laluce

et al. 2023

Biomolecules

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Synucleins are a family of small, soluble proteins mainly expressed in neural tissue and in certain tumors. Since their discovery, tens of thousands of scientific reports have been published about this family of proteins as they are associated with severe human diseases. Although the physiological function of these proteins is still elusive, their relationship with neurodegeneration and cancer has been clearly described over the years. In this review, we summarize data connecting synucleins and cancer, going from the structural description of these molecules to their involvement in tumor-related processes, and discuss the putative use of these proteins as cancer molecular biomarkers.

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Gamma‐synuclein is a novel prognostic marker that promotes tumor cell migration in biliary tract carcinoma

Cited by 9 publications

References 51 publications

Differential Responses of Retinal Neurons and Glia Revealed via Proteomic Analysis on Primary and Secondary Retinal Ganglion Cell Degeneration

Differential Responses of Retinal Neurons and Glia Revealed via Proteomic Analysis on Primary and Secondary Retinal Ganglion Cell Degeneration

Identification and validation of anoikis-associated gene SNCG as a prognostic biomarker in gastric cancer

Synuclein Proteins in Cancer Development and Progression

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