Synuclein Proteins in Cancer Development and Progression

Zanotti, Lucía C.; Malizia, Florencia; Cesatti Laluce, Nahuel; Avila, Aylén; Mamberto, Macarena; Anselmino, Luciano E.; Menacho-Márquez, Mauricio

doi:10.3390/biom13060980

Cited by 4 publications

(9 citation statements)

References 117 publications

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“…Due to the extensive research on PD, studies on the functions of α-synuclein often focus on neurons. However, it is intriguing to note that α-synuclein is highly expressed not only in neurons but also in cells of the hematopoietic system and certain malignant tumors (Araki et al 2018 ; Zanotti et al 2023 ). At this stage, definitive conclusions cannot be drawn.…”

Section: Physiological Functions Of α-Synuclein In Pd Pathogenesismentioning

confidence: 99%

Current trends in basic research on Parkinson’s disease: from mitochondria, lysosome to α-synuclein

Matsui,

Takahashi

2024

J Neural Transm

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Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra and other brain regions. A key pathological feature of PD is the abnormal accumulation of α-synuclein protein within affected neurons, manifesting as Lewy bodies and Lewy neurites. Despite extensive research efforts spanning several decades, the underlying mechanisms of PD and disease-modifying therapies remain elusive. This review provides an overview of current trends in basic research on PD. Initially, it discusses the involvement of mitochondrial dysfunction in the pathogenesis of PD, followed by insights into the role of lysosomal dysfunction and disruptions in the vesicular transport system. Additionally, it delves into the pathological and physiological roles of α-synuclein, a crucial protein associated with PD pathophysiology. Overall, the purpose of this review is to comprehend the current state of elucidating the intricate mechanisms underlying PD and to outline future directions in understanding this disease.

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Section: Physiological Functions Of α-Synuclein In Pd Pathogenesismentioning

confidence: 99%

Current trends in basic research on Parkinson’s disease: from mitochondria, lysosome to α-synuclein

Matsui,

Takahashi

2024

J Neural Transm

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“…In addition to its role in PD, αS has been implicated in the pathology of various cancers [93,94]. It's been observed that elevated levels of αS could influence tumor growth and metastasis in particular cancer types, including breast cancer and colorectal cancer [95].…”

Section: Exploring Genetic Intersections: Parkinson's Associated Gene...mentioning

confidence: 99%

Two Sides of the Same Coin: Genes Involved in Neurodegeneration and Cancer

Montanari,

Meringolo,

El Atiallah

et al. 2024

Preprint

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The relationship between cancer and neurodegeneration has spurred extensive scientific discourse, challenging their historical classification as distinct disorders. While cancer signifies uncontrolled cellular proliferation and neurodegeneration marks progressive neuronal loss, recent insights highlight intriguing interconnections between these seemingly disparate conditions. Cancer entails perpetual signaling for growth, evasion of growth inhibitors, resistance to cell death, acquisition of replicative immortality, stimulation of blood vessel growth (angiogenesis), and initiation of invasion and metastasis. Conversely, investigations emphasize disrupted cellular energy regulation and evasion of immune surveillance as key traits arising from genome instability, mutations, and inflammation driving tumorigenesis. Neurodegeneration involves neuronal malfunction and depletion, synaptic impairment, and protein abnormalities aggregations contributing to muscle atrophy and cognitive deficits. Varied clinical studies underscore contrasting correlations between cancer and neurodegeneration, hinting at mirrored molecular pathways that foster cell resilience or vulnerability. Research explores cellular signaling in tumorigenesis, shared with neurodegenerative disorders. Aberrant expression or mutations in crucial genes implicated in neurodegeneration also surface in cancer contexts. Debates persist on the nature of the relationship between cancer and neurodegeneration, contemplating inverse associations or shared pathways. Understanding their complex interplay, encompassing genetics, cellular mechanisms, and environmental influences, remains pivotal in unraveling their connections. This review explores the intriguing perspective that neurodegeneration and cancer might share fundamental genetic links, delving into potential implications for their onset and progression.

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“…Cooperates with mGluR5 and γ-synuclein [11]. Involved in autophagy, mitochondrial metabolism, and ROS generation [12]. Regulates pro-and antiapoptotic processes [13].…”

Section: Synucleins α-Synucleinmentioning

confidence: 99%

“…Accumulation of misfolded α-synuclein oligomers increases vulnerability of neurons to dopamine-induced cell death. Affects mitochondrial metabolism, autophagy, and the generation of ROS [12].…”

Section: Synucleins α-Synucleinmentioning

confidence: 99%

“…The association of synucleins with cancer was first documented for γ-synuclein in breast cancer [70] and later in several other types of cancer [43,[71][72][73]. Accumulating data indicates that two other members of the synuclein family (α and β) are also associated with tumorigenesis (reviewed in [12]]. For example, both β-synuclein and γ-synuclein are highly expressed in stage III-IV of breast ductal carcinomas, while all three types of synucleins are present in ovarian carcinomas [72].…”

Section: Synucleins In Cancermentioning

confidence: 99%

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Association between Parkinson’s Disease and Cancer: New Findings and Possible Mediators

Surguchov,

Surguchev

2024

IJMS

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Epidemiological evidence points to an inverse association between Parkinson’s disease (PD) and almost all cancers except melanoma, for which this association is positive. The results of multiple studies have demonstrated that patients with PD are at reduced risk for the majority of neoplasms. Several potential biological explanations exist for the inverse relationship between cancer and PD. Recent results identified several PD-associated proteins and factors mediating cancer development and cancer-associated factors affecting PD. Accumulating data point to the role of genetic traits, members of the synuclein family, neurotrophic factors, the ubiquitin–proteasome system, circulating melatonin, and transcription factors as mediators. Here, we present recent data about shared pathogenetic factors and mediators that might be involved in the association between these two diseases. We discuss how these factors, individually or in combination, may be involved in pathology, serve as links between PD and cancer, and affect the prevalence of these disorders. Identification of these factors and investigation of their mechanisms of action would lead to the discovery of new targets for the treatment of both diseases.

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Synuclein Proteins in Cancer Development and Progression

Cited by 4 publications

References 117 publications

Current trends in basic research on Parkinson’s disease: from mitochondria, lysosome to α-synuclein

Current trends in basic research on Parkinson’s disease: from mitochondria, lysosome to α-synuclein

Two Sides of the Same Coin: Genes Involved in Neurodegeneration and Cancer

Association between Parkinson’s Disease and Cancer: New Findings and Possible Mediators

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