Gamma scintigraphic studies on guar gum-based compressed coated tablets for colonic delivery of theophylline in healthy volunteers

Celkan, Armağan; Acartürk, Füsun; Tuğcu-Demiröz, Fatmanur; Gökçora, Nahide; Akkaş, Burcu Esen; Güner, Levent

doi:10.1016/j.jddst.2016.01.009

Cited by 14 publications

(1 citation statement)

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“…Many different systems were designed based on these unique features to deliver different drugs to the colon. The degradation of natural polymers, especially polysaccharides, by bacterial enzymes is the most appropriate colonic design method [44] [45]. Negligible drug release is observed until the designed system reaches the gut and contacts with digestive enzymes.…”

Section: Resultsmentioning

confidence: 99%

In Vitro and in Vivo Evaluation of Pectin-based Melatonin Nanoparticles for the Treatment of Inflammatory Bowel Disease

Yener

Akbulut

Karakuş

et al. 2021

Preprint

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Inflammatory bowel disease (IBD) is a general term including long-term inflammatory disorders of all or some parts of the digestive system. Nanoparticles (NPs) can accumulate in the inflamed zone independently of the polymers’ mucoadhesive character. The aim of this study was to prepare and investigate the melatonin loaded pectin-based nanoparticles for Inflammatory Bowel Disease (IBD). Melatonin (MEL) was loaded into nanoparticle system with a modified ionotropic-gelation method. In vitro characterization studies of the nanoparticles were carried out. The effectiveness of the oral and intracolonically administered nanoparticles were investigated in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rats. The indicators of oxidative stress in the colonic tissue like nitric oxide, malondialdehyde, glutathione, tumor necrosis factor-alpha, Interleukin (IL)-10, and IL-17 levels were investigated. In addition, the histological evaluation was performed. The mean diameter, zeta potential and polydispersity index values of the obtained nanoparticles were 75.3±3.3 nm, 24.24±1.03 mV and 0.109±0.067, respectively. The in vitro drug release studies showed that 84.0±0.7% of the drug was released from the nanoparticles for 8 h. MEL-loaded pectin nanoparticles ameliorated the TNBS-induced colitis. Treatment of the melatonin decreased the damage score by 73.2% in oral and by 67.1% in intracolonic route, respectively. A meaningful decrease was observed in colonic ﬁbrosis, oxidative stress, and inﬂammatory parameters of the colon accompanying histologic injury. The results of the experiments and histological data showed that MEL-loaded calcium pectinate nanoparticle may be a promising alternative in colonic tissue damage which develops due to oxidative stress in IBD.

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Section: Resultsmentioning

confidence: 99%