Stimuli-responsive guar gum composites for colon-specific drug delivery

Jana, Sougata; Maiti, Sabyasachi; Jana, Subrata

doi:10.1016/b978-0-08-101914-6.00003-x

Cited by 5 publications

(3 citation statements)

References 76 publications

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“…Amah et al (2019) encapsulated catechin in starch-based nanoparticles, providing protection to the catechin against the harsh gastric environment and helping to retain its bioactive properties during an in vitro digestion process [147]. Jana et al (2017) reviewed different strategies for generating three-stimuli-responsive guar gum composites (pH, time, and enzymes) for colon-specific drug delivery [148]. Finally, Saffarzadeh-Matin et al (2017) prepared an apple pomace polyphenolic extract and encapsulated it in maltodextrin in nanocapsules of 52 nm diameter, optimizing the loading efficiency of the process [149].…”

Section: Polysaccharides and Derived Polysaccharidesmentioning

confidence: 99%

Recent Advances in Polymer Nanomaterials for Drug Delivery of Adjuvants in Colorectal Cancer Treatment: A Scientific-Technological Analysis and Review

et al. 2020

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Colorectal cancer (CRC) is the type with the second highest morbidity. Recently, a great number of bioactive compounds and encapsulation techniques have been developed. Thus, this paper aims to review the drug delivery strategies for chemotherapy adjuvant treatments for CRC, including an initial scientific-technological analysis of the papers and patents related to cancer, CRC, and adjuvant treatments. For 2018, a total of 167,366 cancer-related papers and 306,240 patents were found. Adjuvant treatments represented 39.3% of the total CRC patents, indicating the importance of adjuvants in the prognosis of patients. Chemotherapy adjuvants can be divided into two groups, natural and synthetic (5-fluorouracil and derivatives). Both groups can be encapsulated using polymers. Polymer-based drug delivery systems can be classified according to polymer nature. From those, anionic polymers have garnered the most attention, because they are pH responsive. The use of polymers tailors the desorption profile, improving drug bioavailability and enhancing the local treatment of CRC via oral administration. Finally, it can be concluded that antioxidants are emerging compounds that can complement today’s chemotherapy treatments. In the long term, encapsulated antioxidants will replace synthetic drugs and will play an important role in curing CRC.

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Section: Polysaccharides and Derived Polysaccharidesmentioning

confidence: 99%

Recent Advances in Polymer Nanomaterials for Drug Delivery of Adjuvants in Colorectal Cancer Treatment: A Scientific-Technological Analysis and Review

et al. 2020

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“…5,6 As a result, they have enormous potential for use in various fields such as medicine, transportation, agriculture, packaging, water treatment, optics, and electronics. [5][6][7][8][9][10][11][12][13][14] Among all the potential biopolymers used in nanocomposite production, NR is one of the most important renewable natural resources derived from the rubber tree. It possesses superior strength, flexibility, resilience, elasticity, abrasion resistance, and is extensively utilized as the elastomeric matrix of various materials, including tires, conveyor belts, and sealing rings.…”

Section: Introductionmentioning

confidence: 99%

“…as compared to conventional micro‐ and macro‐composites 5,6 . As a result, they have enormous potential for use in various fields such as medicine, transportation, agriculture, packaging, water treatment, optics, and electronics 5–14 …”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of epoxidized natural rubber nanocomposites reinforced with mercapto‐functionalized nanozirconia filler

Toiserkani

2023

Polymer Composites

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The objective of this study was to develop a new type of nanocomposite material by reinforcing epoxidized natural rubber (ENR) through the integration of mercapto‐functionalized nanozirconia (SH‐ZrO2 NPs) synthesized using a ring‐opening reaction. The ENR was prepared through the epoxidation of natural rubber (NR) using in situ generated performic acid from formic acid and hydrogen peroxide. The SH‐ZrO2 NPs were pretreated and systematically embedded into the ENR matrix via a latex‐casting process, resulting in ENR/SH‐ZrO2 nanocomposites with enhanced properties. To prevent the accumulation of nanofillers in the ENR matrix, the surface of the nanozirconia was treated with 3‐(mercaptopropyl)trimethoxysilane (MTS) to create mercapto‐terminated ZrO2 NPs (SH‐ZrO2 NPs) that were covalently attached to the ENR chains. The presence of MTS on the surface of the nanozirconia was confirmed by FTIR and thermogravimetric analysis (TGA) analyses. Structural and morphological characterization of the resulting nanocomposites was performed using standard techniques such as x‐ray diffraction (XRD), scanning electron microscopy (SEM), and TGA. The morphological studies indicated a uniform distribution of SH‐ZrO2 NPs throughout the ENR matrix. Furthermore, TGA analysis revealed that the thermal stability of the nanocomposites was improved, as evidenced by a shift in the decomposition temperature to a higher value compared to neat ENR. Overall, this work demonstrates the potential of SH‐ZrO2 NPs as an effective reinforcing agent in ENR‐based nanocomposites, with improved thermal stability and homogeneity.Highlights Enhanced nanocomposite properties: Integration of mercapto‐functionalized nanozirconia improves the performance of epoxidized natural rubber (ENR) materials. Innovative synthesis approach: SH‐ZrO2 NPs synthesized via ring‐opening reaction offer a novel method for reinforcing ENR matrices. Improved thermal stability: ENR/SH‐ZrO2 nanocomposites exhibit higher decomposition temperatures, indicating enhanced thermal stability. Uniform dispersion: Morphological studies confirm the uniform distribution of SH‐ZrO2 NPs throughout the ENR matrix. Promising reinforcing agent: SH‐ZrO2 NPs demonstrate their potential as an effective filler for ENR‐based nanocomposites, enhancing homogeneity and performance.

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Mucoadhesive guargum hydrogel inter-connected chitosan-g-polycaprolactone micelles for rifampicin delivery

Yuan

Praphakar

Munusamy

et al. 2019

Carbohydrate Polymers

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Stimuli-responsive guar gum composites for colon-specific drug delivery

Cited by 5 publications

References 76 publications

Recent Advances in Polymer Nanomaterials for Drug Delivery of Adjuvants in Colorectal Cancer Treatment: A Scientific-Technological Analysis and Review

Recent Advances in Polymer Nanomaterials for Drug Delivery of Adjuvants in Colorectal Cancer Treatment: A Scientific-Technological Analysis and Review

Fabrication and characterization of epoxidized natural rubber nanocomposites reinforced with mercapto‐functionalized nanozirconia filler

Mucoadhesive guargum hydrogel inter-connected chitosan-g-polycaprolactone micelles for rifampicin delivery

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