Gamma radiolysis and solar photolysis of bilirubin: Similarities and differences

Pillay, A. E.; Salih, Fadhil M.

doi:10.1023/b:jrnc.0000030959.94570.d5

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…It is, therefore, desirable to find rapid and more efficient methods for management of hyperbilirubinemia. An ever first study demonstrating degradation of bilirubin to biliverdin (an excretable product) in vitro by gamma irradiation was reported from our laboratory [12] followed by others [27, 28], which verified these results. This in vitro work could not be extended to in vivo experiments due to non-availability of suitable animal models.…”

Section: Introductionsupporting

confidence: 68%

Optimization of phenylhydrazine induced hyperbilirubinemia in experimental rabbit

2016

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Induction of hyperbilirubinemia in experimental rabbits by phenylhydrazine was optimized in terms of dose, dose interval and number of doses using response surface methodology. Central Composite Design was employed using five levels for each of the three input variables. Degree of hyperbilirubinemia was measured in terms of bilirubin level in serum of animals. A dose dependent significant elevation (P<0.05) of total serum bilirubin level was observed which was optimized by using eight factorial, six axial and six central points as suggested by experimental design. Optimum levels of phenylhydrazine dose, total number of doses and a dose interval to achieve maximum elevation (4.06 mg/dl−1) of total serum bilirubin were found to be 11.56 mg/kg−1 body weight, 8 and 24.65 h, respectively. The induction procedure was validated by performing five replicate experiments on a group of five animals which showed 3.56 ± 0.47 mg/kg−1 body weight elevation in total serum bilirubin level.

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Section: Introductionsupporting

confidence: 68%

Optimization of phenylhydrazine induced hyperbilirubinemia in experimental rabbit

2016

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“…Photosensitization reactions are also involved in effective therapies for the control of certain types of cancer, psoriasis, vitiligo and other skin diseases (Smith, 1989). Photosensitization technology has previously been employed for the purification of contaminated water, infectious blood and controlling neonatal bilirubemia (MacCormack, 2008;Pasale et al, 1976;Pillay & Salih, 2004).…”

Section: Introductionmentioning

confidence: 99%

Application of Pt.TiO2 Nanofibers in Photosensitized Degradation of Rhodamine B

Obuya¹,

Joshi²,

Gray³

et al. 2013

IJC

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The surface properties of TiO 2 nanofibers were utilized for the in-situ and ex-situ nucleation and growth of metal nanoparticles. Pt nanoparticles were generated on the titania surface without the use of external stabilizing agents. These nanoparticles were effectively anchored on the numerous pores present on the TiO 2 surface and acted as sites for continued nanoparticle growth. The TiO 2 surface exhibited extensive folding resulting in increased surface area that was then explored for the effective adsorption of reacting materials for heterogeneous catalysis. The resulting TiO 2-based catalysts were found to facilitate UV/Visible light sensitized degradation of Rhodamine B (RH-B). The photodegradation followed first order kinetics with a rate constant of 0.0158 min-1. An investigation of the mechanism of RH-B degradation suggests a role of reactive oxygen species (ROS) as intermediates in the photodegradation process.

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Kinetics of oxidation of bilirubin and its protein complex by hydrogen peroxide in aqueous solutions

Solomonov

Rumyantsev

Антина

2010

Russ. J. Phys. Chem.

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Gamma radiolysis and solar photolysis of bilirubin: Similarities and differences

Cited by 3 publications

References 13 publications

Optimization of phenylhydrazine induced hyperbilirubinemia in experimental rabbit

Optimization of phenylhydrazine induced hyperbilirubinemia in experimental rabbit

Application of Pt.TiO2 Nanofibers in Photosensitized Degradation of Rhodamine B

Kinetics of oxidation of bilirubin and its protein complex by hydrogen peroxide in aqueous solutions

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