Kinetics of oxidation of bilirubin and its protein complex by hydrogen peroxide in aqueous solutions

Solomonov, Alexey V.; Rumyantsev, E. V.; Антина, Е. В.

doi:10.1134/s0036024410120095

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…The resulting spectral and kinetic parameters suggest a general scheme of oxidative transformations in the electron‐donor DMSO medium. The significant increase in kinetics (more than 300 times) of the BR oxidation, compared to its oxidation in aqueous solution with hydrogen peroxide ( k = 18.99 × 10 −4 dm 3 mol −1 s −1 , T = 298.2 K ), is associated with the formation of another transition state form. Another important difference from aqueous solutions is that the end products of oxidation are not monopyrrolic derivatives.…”

Section: Discussionmentioning

confidence: 99%

“…The effectiveness of a BV‐reductase cycle had been clinically proved . Based on previous studies , BR oxidation by atmospheric oxygen or hydrogen peroxide in a phosphate buffer medium is studied. The proton exchange interaction mechanism is related to the interaction of NH groups with peroxyl or hydroxyl radicals leading to form an intermediate product with high reactivity and its subsequent decay to monopirrolic compounds.…”

Section: Introductionmentioning

confidence: 99%

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Kinetics and Mechanism of Bilirubin Oxidation by Benzoyl Peroxide in Dimethyl Sulfoxide

Serebryakova

Solomonov

Rumyantsev

et al. 2014

Int J of Chemical Kinetics

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The kinetics of the redox reaction of bilirubin by the action of benzoyl peroxide in dimethyl sulfoxide was analyzed. It is shown that the first reaction product is biliverdin, which oxidizes to purpurin and further to choletelin. The kinetic and activation parameters of the oxidation reactions were obtained. A kinetic model of the process was proposed. An assumed route of the reaction is related to the exchange interaction of CH protons of methylene and methine spacers with free radicals in the rate‐limiting step with the further destruction of the “ridge‐tile” pigment conformation. The mechanism steps are confirmed by quantum‐chemical calculations and HPLC. It is found that in organic solvents the end products of bilirubin oxidation are not monopyrrolic derivatives. The data obtained will be useful in constructing antioxidant action models of the pigment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Kinetics and Mechanism of Bilirubin Oxidation by Benzoyl Peroxide in Dimethyl Sulfoxide

Serebryakova

Solomonov

Rumyantsev

et al. 2014

Int J of Chemical Kinetics

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Spectroscopic Studies of the Supramolecular Interactions Between Uracil and 5-Hydroxy-6-Methyluracil with Bovine Serum Albumin and its Bilirubin Complex

et al. 2013

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Using fluorescence and absorption spectroscopy the interaction of bovine serum albumin and its bilirubin complex with uracil and 5-hydroxy-6-methyluracil in phosphate buffer at pH 7.4 was investigated. The parameters of forming intermolecular complexes (binding constants, quenching rate constants, the radius of the quenching sphere and etc.) were determined. The interaction between serum albumin and uracils is carried out by the static quenching of protein fluorescence and has predominantly hydrophobic character. Using synchronous fluorescence spectroscopy the influence of uracil and 5-hydroxy-6-methyluracil on the conformational changes of the protein molecule was studied. Uracils effectively binds to bilirubin-albumin complex compared to free protein, which is caused by the interaction with tetrapyrrolic pigment in macromolecular complex. Molecular docking calculations also being presented.

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The kinetics of oxidation of bilirubin and ascorbic acid in solution

Solomonov

Rumyantsev

Kochergin

et al. 2012

Russ. J. Phys. Chem.

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Kinetics of oxidation of bilirubin and its protein complex by hydrogen peroxide in aqueous solutions

Cited by 4 publications

References 8 publications

Kinetics and Mechanism of Bilirubin Oxidation by Benzoyl Peroxide in Dimethyl Sulfoxide

Kinetics and Mechanism of Bilirubin Oxidation by Benzoyl Peroxide in Dimethyl Sulfoxide

Spectroscopic Studies of the Supramolecular Interactions Between Uracil and 5-Hydroxy-6-Methyluracil with Bovine Serum Albumin and its Bilirubin Complex

The kinetics of oxidation of bilirubin and ascorbic acid in solution

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