Gamma knife radiosurgery for recurrent gliomas

Sadik, Zjiwar H A; Hanssens, Patrick; Verheul, Jeroen B; Beute, Guus; Lie, Suan Te; Leenstra, Sieger; Ardon, Hilko

doi:10.1007/s11060-018-2988-0

Cited by 18 publications

(15 citation statements)

References 26 publications

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“…We analyzed the data with respect to GKRS in our center and found a median PFS of 4 months and a median OS of 13 months after GKRS, indicating its efficacy in the treatment of malignant glioma. Sadik et al [10] found that the median PFS and OS were 5.7 and 12.8 months after GKRS in a cohort of 94 recurrent glioma patients without any serious complications. Imber et al [6] reported a median OS of 10.6 months in 174 glioblastoma cases after GKRS.…”

Section: Discussionmentioning

confidence: 99%

“…It has advantages in the management of glioma, including accurate location, a steep dose distribution gradient, a small impact on the surrounding tissue, and low cost. In a recent review, the DOI: 10.1159/000509782 longest median overall survival (OS) was found with GKRS as a salvage therapy [10]. Many doctors also use GKRS as a supplementary treatment after surgery, intensity-modulated radiation therapy, and chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

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Gamma Knife Radiosurgery for High-Grade Gliomas: Single-Center Experience of Six Years in China

Zhao

Zhang

et al. 2021

Stereotact Funct Neurosurg

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Objective: The aim of this study was to evaluate the efficacy of Gamma Knife radiosurgery (GKRS) as a salvage therapy for high-grade glioma in our center. Methods: A total of 167 patients with malignant glioma were treated with GKRS in our Gamma Knife Center between January 2013 and December 2017; 140 patients (85 males and 55 females) were followed up and enrolled in our study. A single lesion was found in 110 cases, and multiple lesions were found in 30 cases; 108 cases received a single therapy, and in 32 cases, at least 2 GKRSs were performed. The median tumor volume was 13.5 cm3. The mean radiation dosage was 14.35 Gy (range, 6–18 Gy). MRI was performed regularly. The RANO criteria and Cox analysis were used to evaluate the therapeutic efficiency. Results: Follow-up MRI showed the local control rate was 61.4% at 3 months after GKRS, 25.0% at 6 months, and 7.1% at 12 months. The mean and median progression-free survival (PFS) periods were 8.6 (95% CI, 6.3–11.0) and 4 (95% CI, 3.5–4.5) (range, 1–60) months, respectively. The overall survival (OS) after GKRS was 3–62 months, with a mean of 16.7 (95% CI, 14.6–18.9) months, and the median survival was 13 (95% CI, 12.1–13.9) months. The 1-, 2-, and 5-year survival rates were 51.4, 10.0, and 2.9%, respectively. No severe complications occurred. Cox regression showed that glioma pathology was closely related to prognosis (p < 0.05). The Karnofsky Performance Score had little influence on PFS (p > 0.05) but influenced OS significantly (p < 0.05). Conclusion: GKRS can be used to effectively treat malignant brain glioma and can therefore be used as an alternative treatment option.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gamma Knife Radiosurgery for High-Grade Gliomas: Single-Center Experience of Six Years in China

Zhao

Zhang

et al. 2021

Stereotact Funct Neurosurg

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“…However, based on histogenesis and biological characteristics, a similar occurrence of neuroectodermal tumors in a variety of complex tumors is generally referred to as “glioma” 3,4. The incidence of gliomas ranges from 3 to 8 per 100,000 people in China while the global morbidity ranges from 4.67 to 5.73 per 100,000 people 5,6…”

Section: Introductionmentioning

confidence: 99%

LncRNA RHPN1-AS1 Targeting miR-625/REG3A Promotes Cell Proliferation And Invasion Of Glioma Cells

Cui¹,

Su²,

Li³

et al. 2019

OTT

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IntroductionGlioma arises from the proliferation of neuroglial cells differentiated from the ectoderm. Evidence has confirmed that differentially expressed long non-coding RNAs (lncRNAs) may be involved in the development and progression of various tumors. The present study aimed to explore the biological function of lncRNA RHPN1-AS1 in glioma.Materials and methodsThe expressions of RHPN1-AS1 in glioma tissues and cells were examined using RT-PCR. Colony formation assay, MTT assay, wound healing assay and transwell assay were performed to detect cell cloning efficiency, proliferation, migration and invasion of glioma cells, respectively. Western blot was applied to assess the expression levels of migration-related and invasion-related proteins. Online bioinformatic tools and luciferase reporter assay were, respectively, employed to predict and verify the downstream target microRNA/gene of RHPN1-AS1.ResultsRHPN1-AS1 was up-regulated in glioma tissues and cells. The cell proliferation, migration and invasion of glioma were inhibited when the expression of RHPN1-AS1 was down-regulated in glioma cells. The expressions of migration-related and invasion-related proteins were also suppressed in siRHPN1-AS1 groups. Furthermore, we predicted and verified that RHPN1-AS1 was directly targeted to miR-625-5p/REG3A. Our study demonstrated that the knockdown of RHPN1-AS1 inhibited the proliferation, migration and invasion activity of glioma cells via regulating miR-625-5p/REG3A expression.ConclusionThe results revealed that the lncRNA RHPN1-AS1 may be a molecular target in glioma therapy.

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“…Glioma is the most common primary intracranial malignant tumor and accounts for 30% of all central nervous system tumors 1 , 2 . The World Health Organization (WHO) classification of central nervous system tumors places gliomas into grades I-IV, with grades I and II indicating low-grade gliomas and grades III and IV, high-grade gliomas (HGGs) 3 .…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of HGGs is approximately 5 per 100,000 person-years. Researches have shown that gliomas are more common in adults and the elderly than in children; they also occur more often in men than in women 1 , 2 , 4 , 5 . HGGs are characterized by the "three high and one low" principle: high incidence rate, high recurrence rate, high mortality, and low cure rate.…”

Section: Introductionmentioning

confidence: 99%

Advances in radiotherapy and comprehensive treatment of high-grade glioma: immunotherapy and tumor-treating fields

et al. 2021

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Gamma knife radiosurgery for recurrent gliomas

Abstract: GKRS can safely be used as salvage treatment for recurrent glioma and seems to improve survival rates in (high grade) glioma patients with minimal burden.

Cited by 18 publications

References 26 publications

Gamma Knife Radiosurgery for High-Grade Gliomas: Single-Center Experience of Six Years in China

Gamma Knife Radiosurgery for High-Grade Gliomas: Single-Center Experience of Six Years in China

<p>LncRNA RHPN1-AS1 Targeting miR-625/REG3A Promotes Cell Proliferation And Invasion Of Glioma Cells</p>

Advances in radiotherapy and comprehensive treatment of high-grade glioma: immunotherapy and tumor-treating fields

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