Gamma Knife Radiosurgery for High-Grade Gliomas: Single-Center Experience of Six Years in China

Zhao, Ming; Fu, Xiangsheng; Zhang, Zhiwen; Ma, Liang; Wang, Xiaopeng; Li, Xuexiu

doi:10.1159/000509782

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…The 1-, 2-, and 5-year survival rates were 51.4, 10.0, and 2.9%, respectively. As expected, the tumor grade and KPS were prognostic factors [45].…”

Section: Clinical Studiessupporting

confidence: 77%

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Radiotherapy of High-Grade Gliomas: First Half of 2021 Update with Special Reference to Radiosensitization Studies

Fròsina

2021

IJMS

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Albeit the effort to develop targeted therapies for patients with high-grade gliomas (WHO grades III and IV) is evidenced by hundreds of current clinical trials, radiation remains one of the few effective therapeutic options for them. This review article analyzes the updates on the topic “radiotherapy of high-grade gliomas” during the period 1 January 2021–30 June 2021. The high number of articles retrieved in PubMed using the search terms (“gliom* and radio*”) and manually selected for relevance indicates the feverish research currently ongoing on the subject. During the last semester, significant advances were provided in both the preclinical and clinical settings concerning the diagnosis and prognosis of high-grade gliomas, their radioresistance, and the inevitable side effects of their treatment with radiation. The novel information concerning tumor radiosensitization was of special interest in terms of therapeutic perspective and was discussed in detail.

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“…The 1-, 2-, and 5-year survival rates were 51.4, 10.0, and 2.9%, respectively. As expected, the tumor grade and KPS were prognostic factors [45].…”

Section: Clinical Studiessupporting

confidence: 77%

“…The efficacy of gamma knife radiosurgery as a salvage therapy for HGG has been investigated by Zhao et al [45]. The median OS after gamma knife radiosurgery was 13 months.…”

Section: Clinical Studiesmentioning

confidence: 99%

Radiotherapy of High-Grade Gliomas: First Half of 2021 Update with Special Reference to Radiosensitization Studies

Fròsina

2021

IJMS

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“…SRS is currently used to treat patients with a variety of processes including cerebral vascular malformations (arteriovenous malformations or AVMs [ 15 ] and cavernous angiomas [ 16 ]), benign tumors (meningiomas [ 17 - 18 ], vestibular schwannoma [ 19 ], pituitary adenoma [ 20 - 21 ], glomus jugulare tumors [ 22 ], low-grade glioma [ 23 ]), and malignant tumors (metastasis [ 24 ], chordoma [ 25 ], high-grade glioma [ 26 ]). Other less common indications are Cushing's disease [ 27 - 28 ], epilepsy [ 29 ], trigeminal neuralgia [ 30 ], and movement disorders [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Intracranial Tumors With Stereotactic Radiosurgery: Short-Term Results From Cuba

Aquino¹,

Ramirez²,

Bozkurt³

et al. 2022

Cureus

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BackgroundAlthough international publications on radiosurgery have increased exponentially, reports of heterogeneous series treated with linear accelerator (LINAC) are scarce. Since most intracranial tumors are irregular in size and not spherical, LINACs (Elekta Precise®, Elekta AB, Sweden), fitted with a multi-leaf collimator, allow for precise stereotactic radiosurgery for the entire tumor. AimTo evaluate the effects of LINAC on an outpatient basis with patients diagnosed with various intracranial malignancies. MethodologyA retrospective observational study of a series of cases of patients with intracranial lesions treated at the Institute of Oncology and Radiobiology using LINAC was carried out from October 2019 to May 2021 to evaluate the therapeutic results of radiosurgery in patients with intracranial tumors. ResultsA total of 22 lesions in 20 patients were treated with LINAC. The average age of the patients was 49.7, and the male-female ratio was 1:2. The cases consisted were mostly vestibular schwannoma (7 lesions), metastases from breast cancer (3 lesions), and tuberculum sellae meningioma (2 lesions). The prescription dose covered 99% of the planning target volume in 16 lesions (72.7%) and 100% in six lesions (27.3%) (prescription volume). In meningiomas and schwannomas, doses between 12 and 14 Gy were used, in plasmacytoma 13 Gy, in pilocytic astrocytoma 14 Gy, in cavernoma 15 Gy, in breast cancer metastasis between 18 and 20 Gy, and in lung cancer metastasis 22 Gy. When evaluating local control, 11 patients exhibited stable findings at the six-month control while 10 had partial regression, and a single patient had total regression. Minor complications such as perilesional edema, facial paresthesia, facial paralysis, and transient alopecia were observed in eight of the patients. ConclusionsPatients with extra-axial, low-grade malignancy, and posterior fossa lesions were predominant in the studied population. Radiosurgery treatment is associated with good local control of the treated lesions. Complications are infrequent, mild, and predominated by perilesional edema.

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Gamma Knife Radiosurgery for High-Grade Gliomas: Single-Center Experience of Six Years in China

Cited by 2 publications

References 20 publications

Radiotherapy of High-Grade Gliomas: First Half of 2021 Update with Special Reference to Radiosensitization Studies

Radiotherapy of High-Grade Gliomas: First Half of 2021 Update with Special Reference to Radiosensitization Studies

Treatment of Intracranial Tumors With Stereotactic Radiosurgery: Short-Term Results From Cuba

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