Gamma interferon-induced nitric oxide production reduces Chlamydia trachomatis infectivity in McCoy cells

Mayer, Jeanmarie; Woods, Marion L.; Vavrin, Zdenek; Hibbs, John B.

doi:10.1128/iai.61.2.491-497.1993

Cited by 91 publications

(44 citation statements)

References 42 publications

(29 reference statements)

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“…DNA damage by nitric oxide and other free radicals released by bacterial infection activated inflammatory cells has been suggested to be oncogenic (Oshima & Bartsch, 1994;Rosin et al, 1994). The liberation of nitric oxide has been demonstrated in chlamydial infections (Mayer et al, 1993), but is not plausible in the lymphoma context.…”

Section: Discussionmentioning

confidence: 97%

Serological evidence of an association between chlamydial infections and malignant lymphomas

et al. 1998

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Chronic infections may predispose to malignant growth. Recently, serological markers of chronic Chlamydia pneumoniae infection have been associated with lung cancer. Our aim was to study the possible association between chronic chlamydial infections and malignant lymphomas. The present case-control study involved 72 patients with lymphoma (31 females and 41 males) and matched controls. 53 patients had non-Hodgkin's lymphoma (NHL) and 19 had Hodgkin's disease. The sera, collected at the time of diagnosis, were tested for IgG antibodies and immune complexes to C. pneumoniae and C. trachomatis by a microimmunofluorescence method and ELISA and for IgG antibodies and immune complexes to Helicobacter pylori by ELISA. The serological markers suggesting chronic chlamydial infection were associated with malignant lymphoma. The association was most evident for the presence of C. pneumoniae-specific immune complexes in NHL (OR = 7.3, 95% CI 2.2-25) and appeared to be limited to men. No association between H. pylori antibodies or immune complexes and malignant lymphomas could be demonstrated. Our study provides seroepidemiological evidence of an association between chronic chlamydial infections and lymphomas.

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Section: Discussionmentioning

confidence: 97%

Serological evidence of an association between chlamydial infections and malignant lymphomas

et al. 1998

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“…The same mechanism has been suggested for the role of schistosomiasis in the development of urinary bladder carcinoma (Rosin et al, 1994). The liberation of nitric oxide has also been shown to occur in chlamydial infections (Mayer et al, 1993). The possibility that chronic C. pneumoniae infection induces carcinogenesis in the lung through mediators of inflammation could thus be a logical consequence from a chronic infection.…”

Section: Discussionmentioning

confidence: 98%

Serological evidence of an association betweenChlamydia pneumoniae infection and lung cancer

Laurila¹,

Anttila²,

et al. 1997

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Epidemiological evidence suggests that airway obstruction is an independent risk factor for lung cancer and that this cannot be explained by active or passive smoking alone. Chlamydia pneumoniae infection has been associated with chronic bronchitis and its exacerbates. Our aim was to evaluate the association between chronic C. pneumoniae infection and risk of lung cancer among male smokers. Smoking males with lung cancer (n 5 230) and their age-and locality-matched controls were selected among participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. The presence of C. pneumoniae infection was assessed by analyzing specific antibodies and immune complexes in 2 serum samples collected with a 3-year interval before the lung cancer diagnosis. The diagnosis of chronic infection was based on stable levels of positive specific IgA antibody (titer H 16) and immune complex (titer H 4). Relative risks were estimated by odds ratios (OR) adjusted for age, locality and smoking history by a conditional logistic regression model. Markers suggesting chronic C. pneumoniae infection were present in 52% of cases and 45% of controls and hence were positively associated with the incidence of lung cancer (OR 1.6; 95% confidence interval [CI] 1.0-2.3). The incidence was especially increased in men younger than 60 years (OR 2.9; 95% CI 1.5-5.4) but not in the older age group (OR 0.9; 95% CI 0.5-1.6). Before concluding that C. pneumoniae infection is a new independent risk factor for lung cancer, corroboration from other studies with larger number of cases and longer follow-up is needed. Int. J. Cancer 74:31-34.Chlamydia pneumoniae is a common intracellular bacterium that causes pneumonia and other respiratory infections world-wide. Like all Chlamydia organisms, it has a tendency to cause persistent and chronic infections. C. pneumoniae has been serologically associated with chronic lung diseases such as chronic bronchitis (von Hertzen et al., 1995) and adult onset asthma (Hahn et al., 1991), as well as and with atherosclerosis (Saikku et al., 1988), in which the organism has been demonstrated in atherosclerotic plaques (Kuo et al., 1993). Chronic bronchitis has been suggested as an independent etiologic factor in lung cancer (Osann, 1991), the effect of which cannot be explained by either active or passive exposure to cigarette smoke. Smoking does, however, appear to promote chronic C. pneumoniae infection, probably through immunosuppression (Karvonen et al., 1994a).In Finland, nearly 30,000 male smokers were followed for 5-8 years in 1985-1993 in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study Group, 1994). We analyzed baseline and 3-year follow-up serum samples from 230 men diagnosed with lung cancer after the third year and their age-, timeand locality-matched controls for C. pneumoniae-specific IgG and IgA antibodies and immune complexes to study the association between markers suggestive of chronic C. pneumoniae infection and lung cancer. MATERIAL AND METHODS Base population and follow-u...

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“…After appropriate stimulation, macrophages produce NO and its metabolites (reactive nitrogen intermediates (RNI)) [16], and express their antimicrobial capabilities [17] by inhibiting cytochrome P450 activity [18] and causing changes in DNA [19]. Several recent studies have demonstrated that RNI play an important role in host defence against infections caused by various pathogens, including parasites [20][21][22][23], fungi [15,[24][25][26], bacteria [27][28][29][30][31], chlamydia [32] and mycobacteria [33][34][35]. In the present study, we examine the role of RNI in the anti-fungal activity of IFN-g-stimulated murine peritoneal macrophages.…”

Section: Introductionmentioning

confidence: 99%

Different susceptibilities of yeasts and conidia ofPenicillium marneffeito nitric oxide (NO)-mediated fungicidal activity of murine macrophages

Kudeken

Kawakami

Saitô

1998

Clinical and Experimental Immunology

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Penicillium marneffei is an important opportunistic fungal pathogen. Host defence mechanisms against P. marneffei are not fully understood. We investigated the fungicidal activity of murine peritoneal macrophages against two forms of P. marneffei, conidia and yeast cells, and the involvement of the NO-mediated killing system. Peritoneal macrophages suppressed the intracellular growth of P. marneffei yeast cells and conidia. The number of live yeast cells within macrophages was significantly reduced by activation of macrophages by interferon-gamma (IFN-gamma), while a similar response was not observed with conidia. IFN-gamma-induced macrophage fungicidal activity against yeast cells was mediated by NO and was almost completely inhibited by N(G)-monomethyl-L-arginine (L-NMMA), a competitive inhibitor of NO synthesis, while N(G)-monomethyl-D-arginine (D-NMMA), an optical isomer of L-NMMA, did not show any influence. NO production by macrophages stimulated with IFN-gamma was significantly enhanced when these macrophages were cultured with P. marneffei yeast cells, while conidia did not enhance macrophage NO production. Furthermore, yeast cells were more susceptible to the killing effect of chemically generated NO than conidia. Our results indicate that the yeast form of P. marneffei is more sensitive to the fungicidal activity of IFN-gamma-stimulated macrophages than conidia, and suggest that the different effects of two forms of P. marneffei on macrophage NO production and their different susceptibilities to NO may be reasons for the present findings.

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Gamma interferon-induced nitric oxide production reduces Chlamydia trachomatis infectivity in McCoy cells

Cited by 91 publications

References 42 publications

Serological evidence of an association between chlamydial infections and malignant lymphomas

Serological evidence of an association between chlamydial infections and malignant lymphomas

Serological evidence of an association betweenChlamydia pneumoniae infection and lung cancer

Different susceptibilities of yeasts and conidia ofPenicillium marneffeito nitric oxide (NO)-mediated fungicidal activity of murine macrophages

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