Gamma-glutamyl transpeptidase, triglycerides, and enzyme induction.

Martin, P.J.; Martin, Jennifer V.; Goldberg, David M.

doi:10.1136/bmj.1.5948.17

Cited by 67 publications

(15 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevated serum GGTP levels have been prominently mentioned in the literature as an index of microsoinal enzyme induction in the human (36)(37)(38)(39)(40). Recent studies (41), however, have in part disputed this conclusion.…”

Section: Pcb Effects On Microsomal Enzymesmentioning

confidence: 79%

Effects of PCB exposure on biochemical and hematological findings in capacitor workers.

Lawton¹,

Ross²,

Feingold³

et al. 1985

Environ Health Perspect

View full text Add to dashboard Cite

Certain former operations in capacitor manufacturing resulted in extensive direct contact of the workers with electrical grade polychlorinated biphenyls (PCBs). A study group of 194 such individuals, all exposed to Aroclor 1016 and many previously exposed to Aroclors 1242 and/or 1254, was examined before (1976) and after (1979) discontinuance of PCB use in the operations (1977). At the two examinations, the approximate geometric mean serum levels (in ppb) and 5 to 95% ranges were for lower PCBs (LPCB), 363 (57-2270) and 68 (12-392); and for higher PCBs (HPCB), 30 (6-142) and 19 (4-108), respectively.The statistical associations among 42 measured clinical chemical and hematological parameters, five different measures of PCB exposure, and seven confounding variables observed in the two examinations were determined by three regression procedures. Similar regressions were performed with DDE, which was present at background levels. The principal statistical findings were a depression in serum bilirubin and elevations in serum GGTP and lymphocyte levels at the time of the first examination, and only an elevation in monocytes at the second. Appraisal of the results suggested an induction of microsomal enzymes which appeared to be subsiding after the cessation of direct exposure to PCBs. The statistical association between serum levels of PCBs and lipids reported by others was confirmed, but shown to be explained by the partitioning behavior of PCB in the body, rather than to changes in liver function. No evidence for health impairment related to PCBs was found, despite the high serum levels of PCBs in the study population.

show abstract

Section: Pcb Effects On Microsomal Enzymesmentioning

confidence: 79%

Effects of PCB exposure on biochemical and hematological findings in capacitor workers.

Lawton¹,

Ross²,

Feingold³

et al. 1985

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…In the case of GGT it may well be similar to the increase caused by hepatic microsomal enzyme-inducing drugs, which raise the plasma GGT (Rosalki et al, 1971;Whitfield et al, 1973). Association between increased GGT and raised triglycerides has been reported (Martin et al, 1975), and it was suggested that the increase in triglycerides was also related to enzyme induction.…”

Section: Imentioning

confidence: 96%

Some Laboratory Correlates of Drinking Habits

et al. 1978

View full text Add to dashboard Cite

SUMMARY The effect of drinking habits on the frequency distributions of eight biochemical or haematological test results was studied in 7915 patients attending a multiphasic health testing centre.Increasing incidences of abnormal results with increasing alcohol intake, at levels of alcohol intake habitual for a large proportion of the population, were found for plasma gamma-glutamyl transpeptidase, triglycerides and uric acid, and for erythrocyte mean corpuscular volume. Of four frequently used liver function tests, aspartate aminotransferase, alkaline phosphatase, bilirubin, and albumin, only aspartate aminotransferase was strongly affected by drinking habits.These findings have relevance for the detection of individuals whose drinking habits are harmful to them, and for the interpretation of 'profile' results.It is well known that alcohol intake is associated with a number of metabolic changes and with overt clinical disease, and the association between alcohol and abnormalities in certain biochemical and haematological test results has been shown by Rosalki and Rau (1972) and by other workers (Rollason et al., 1972;Olin et al., 1973;Spencer-Peet et al., 1973;Ostrander et al., 1974;Unger and Johnson, 1974;Wu et al., 1974;Patel and O'Gorman, 1975).Most studies on this subject have compared groups of 'normal' people (some of whom may be quite heavy drinkers) with patients who are suffering from the clinical and social effects of their drinking -termed 'alcoholics'. We were interested in the effect of different levels of drinking on the results of biochemical tests in the context of a multiphasic health testing programme, in which those attending answer a questionnaire on their health, medical history, and social habits and undergo a number of physiological, biochemical, and haematological tests. This study has been undertaken both to determine the degree of abnormality which may be accounted for by the admitted alcohol intake alone, without seeking other causes, and to detect those individuals whose alcohol intake is producing metabolic changes which may later lead to clinical disease.titioner, but a survey of patient attitudes to Medicheck (Rawson, 1975) has shown that in approximately 60 % of referrals the suggestion of attendance came from the patient rather than from the referring doctor. No detailed analysis of social class has been made, but the survey cited showed that incomes were higher than the Australian average.Blood was taken after fasting since the previous evening, and the subjects then answered about 150 questions related to their medical history, present subjective assessment of health, presence of symptoms, and social habits including alcohol consumption. The questions relating to alcohol are shown in Table 1. Results for seven biochemical tests and one haematological test were abstracted from the data held on computer file and related to the stated alcohol intake for both frequency and amount. Significance of association was assessed by the chisquare test (Bradford Hill, 1971).Results for men ...

show abstract

“…Elevated cholesterol and triglycerides were found following ethanol (Lefevre, de Carli & Lieber, 1972), phenobarbitone (Jones & Armstrong, 1965) and in patients having increased y-glutamyltranspeptidase (Martin, Martin & Goldberg, 1975). These findings were thought to be due to enzyme induction, and therefore plasma lipids and lipoproteins were investigated in the present study following three different enzyme inducing drugs.…”

mentioning

confidence: 81%

A comparison of three different enzyme inducing agents and their influence on plasma lipids in man [proceedings]

Ee¹

1977

Brit J Clinical Pharma

View full text Add to dashboard Cite

Gamma-glutamyl transpeptidase, triglycerides, and enzyme induction.

Cited by 67 publications

References 12 publications

Effects of PCB exposure on biochemical and hematological findings in capacitor workers.

Effects of PCB exposure on biochemical and hematological findings in capacitor workers.

Some Laboratory Correlates of Drinking Habits

A comparison of three different enzyme inducing agents and their influence on plasma lipids in man [proceedings]

Contact Info

Product

Resources

About