Gamma-glutamyl-transpeptidase to platelet ratio is not superior to APRI,FIB-4 and RPR for diagnosing liver fibrosis in CHB patients in China

Huang, Rui; Wang, Guiyang; Tian, Chen; Liu, Yong; Jia, Bin; Wang, Jian; Yang, Yue; Li, Yang; Sun, Zhen; Yan, Xiaomin; Xia, Juan; Xiong, Ye; Song, Peixin; Zhang, Zhaoping; Ding, Weimao; Wu, Chao

doi:10.1038/s41598-017-09234-w

Cited by 35 publications

(42 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found only Lemoine et al's study (11) to be similar to our study. It was conducted mainly in patients who were negative for HBeAg, while other studies enrolled all positive (21) or both patients (20,27,29,30). Another point is that most previous studies were conducted in China but our study and the study by Lemoine et al (11) were conducted in Africa.…”

Section: Discussionmentioning

confidence: 87%

King’s Fibrosis, Fibrosis Index, GPR, and ALBI Score Are Useful Models for Liver Fibrosis in Chronic Hepatitis B Patients Pre- and Post-Treatment

et al. 2019

View full text Add to dashboard Cite

Background: Liver fibrosis is one of the chronic hepatitis B (CHB) indications for treatment. Objectives: We aimed to assess the fibrosis index, FIB-4, King's fibrosis score, albumin-bilirubin (ALBI) score, gamma-glutamyl transferase-platelets (GPR), and gamma-glutamyl transferase-albumin (GAR) ratios as diagnostic models of liver fibrosis in CHB patients. Methods: The study enrolled 217 patients. Liver fibrosis was assessed by transient elastography, which showed 20.3% of the patients had F4 fibrosis. Treatment was given for 33.20 ± 20.94 months. Results: F4 fibrosis patients had higher values (P = 0.001) of Fibrosis index score, FIB-4 score, King's fibrosis score, ALBI score, GPR, and GAR than non-F4 fibrosis patients. All patients had improved values after treatment. The mean treatment-induced changes were comparable in patients with and without virological response. The Fibrosis index of >-32.66 showed 63.64% sensitivity and 91.33% specificity. The FIB-4 score of > 1.88 had 72.73% sensitivity and 91.33% specificity. The King's fibrosis score of > 7.93 demonstrated 90.91% sensitivity and 73.99% specificity. The ALBI score of >-2.7 had 70.45% sensitivity and 86.13% specificity. The GPR value of > 0.69 revealed 70.5% sensitivity and 94.2% specificity. The GAR value of > 1.28 showed 72.73% sensitivity and 46.4% specificity. The GAR was inferior to FIB-4 and GPR (P < 0.05). Conclusions: GPR, fibrosis index, King's fibrosis score, ALBI, and FIB-4 are useful diagnostic models of liver fibrosis in CHB patients.

show abstract

Section: Discussionmentioning

confidence: 87%

King’s Fibrosis, Fibrosis Index, GPR, and ALBI Score Are Useful Models for Liver Fibrosis in Chronic Hepatitis B Patients Pre- and Post-Treatment

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Therefore, we devised the GPR, which could amplify the differences in the GGT and PLT among patients with different inflammation grades, to identify CHB patients with significant liver inflammation. Although increasing studies demonstrated that GPR has well performance in predicting the severity of liver fibrosis, 26,[35][36][37] to the best of our knowledge, few studies have investigated the relationship between GPR and the grades of liver inflammation in patients with CHB.…”

Section: Discussionmentioning

confidence: 99%

A novel index using routine clinical parameters for predicting significant liver inflammation in chronic hepatitis B

Wang

Xia

Zhang

et al. 2018

Journal of Viral Hepatitis

View full text Add to dashboard Cite

Identifying the degree of liver inflammation is critical for therapeutic judgement of patients with chronic hepatitis B (CHB). However, we lack indexes which can accurately predict significant liver inflammation in patients with CHB. This study aimed to develop a simple predictive index for liver inflammation in CHB using routine clinical parameters. A total of 519 patients with CHB who underwent liver biopsy were enrolled and randomly divided into training (n = 346) and validation cohorts (n = 173). Based on routine clinical parameters, gamma-glutamyl transpeptidase (GGT; P = 0.031) and platelets (PLT; P < 0.001) were identified as independent predictors of significant inflammation by multivariable analysis in the training cohort. Accordingly, the GGT to PLT ratio (GPR) was developed to amplify the opposing effects for predicting liver inflammation. In the training cohort, the AUCs of GPR in predicting significant inflammation were 0.791 (95% CI: 0.742-0.839), 0.783 (95% CI: 0.717-0.849) and 0.791 (95% CI: 0.716-0.867) in the entire patients with CHB, HBeAg-positive CHB patients and HBeAg-negative CHB patients, respectively. The diagnostic performance of GPR for significant inflammation was significantly superior to that of alanine aminotransferase (ALT), aspartate transaminase (AST) and GGT in all patients with CHB and HBeAg-positive CHB patients, but was comparable with ALT, AST and GGT in HBeAg-negative CHB patients. In the validation cohort, the diagnostic performance of GPR in assessing significant liver inflammation was also superior to other indexes in all patients with CHB and HBeAg-positive CHB patients, but was comparable with GGT in HBeAg-negative CHB patients. Thus, GPR can be a novel and simple index for predicting significant liver inflammation in CHB, especially for HBeAg-positive CHB.

show abstract

“…Nevertheless, Li et al [60], Huang et al [61], and Lu et al [62] indicated that although GPR is a novel diagnostic model for liver fibrosis or cirrhosis, it does not display advantages compared to APRI and FIB-4 for identifying significant fibrosis, severe fibrosis, and cirrhosis in Chinese CHB patients.…”

Section: Crp To Albumin Ratio (Car)mentioning

confidence: 99%

Review of Serum Biomarkers and Models Derived from Them in HBV-Related Liver Diseases

Mao

2020

Disease Markers

View full text Add to dashboard Cite

A series of predictive scoring systems is available for stratifying the severity of conditions and assessing the prognosis in patients with HBV-related liver diseases. We show nine of the most popular serum biomarkers and their models (i.e., serum cystatin C, homocysteine, C-reactive protein, C-reactive protein to albumin ratio, aspartate aminotransferase to platelet ratio index, fibrosis index based on four factors, gamma-glutamyl transpeptidase to platelet ratio, albumin-bilirubin score, and gamma-glutamyl transpeptidase to albumin ratio) that have gained great interest from clinicians. Compared with traditional scoring systems, these serum biomarkers and their models are easily acquired, simple, and relatively inexpensive. In the present review, we summarize the latest studies focused on these serum biomarkers and their models as diagnostic and prognostic indexes in HBV-related liver diseases.

show abstract

Gamma-glutamyl-transpeptidase to platelet ratio is not superior to APRI,FIB-4 and RPR for diagnosing liver fibrosis in CHB patients in China

Cited by 35 publications

References 31 publications

King’s Fibrosis, Fibrosis Index, GPR, and ALBI Score Are Useful Models for Liver Fibrosis in Chronic Hepatitis B Patients Pre- and Post-Treatment

King’s Fibrosis, Fibrosis Index, GPR, and ALBI Score Are Useful Models for Liver Fibrosis in Chronic Hepatitis B Patients Pre- and Post-Treatment

A novel index using routine clinical parameters for predicting significant liver inflammation in chronic hepatitis B

Review of Serum Biomarkers and Models Derived from Them in HBV-Related Liver Diseases

Contact Info

Product

Resources

About