King’s Fibrosis, Fibrosis Index, GPR, and ALBI Score Are Useful Models for Liver Fibrosis in Chronic Hepatitis B Patients Pre- and Post-Treatment

Abstract

Background: Liver fibrosis is one of the chronic hepatitis B (CHB) indications for treatment. Objectives: We aimed to assess the fibrosis index, FIB-4, King's fibrosis score, albumin-bilirubin (ALBI) score, gamma-glutamyl transferase-platelets (GPR), and gamma-glutamyl transferase-albumin (GAR) ratios as diagnostic models of liver fibrosis in CHB patients. Methods: The study enrolled 217 patients. Liver fibrosis was assessed by transient elastography, which showed 20.3% of the patients had F4 fibrosis. Treatment was given for 33.20 ± 20.94 months. Results: F4 fibrosis patients had higher values (P = 0.001) of Fibrosis index score, FIB-4 score, King's fibrosis score, ALBI score, GPR, and GAR than non-F4 fibrosis patients. All patients had improved values after treatment. The mean treatment-induced changes were comparable in patients with and without virological response. The Fibrosis index of >-32.66 showed 63.64% sensitivity and 91.33% specificity. The FIB-4 score of > 1.88 had 72.73% sensitivity and 91.33% specificity. The King's fibrosis score of > 7.93 demonstrated 90.91% sensitivity and 73.99% specificity. The ALBI score of >-2.7 had 70.45% sensitivity and 86.13% specificity. The GPR value of > 0.69 revealed 70.5% sensitivity and 94.2% specificity. The GAR value of > 1.28 showed 72.73% sensitivity and 46.4% specificity. The GAR was inferior to FIB-4 and GPR (P < 0.05). Conclusions: GPR, fibrosis index, King's fibrosis score, ALBI, and FIB-4 are useful diagnostic models of liver fibrosis in CHB patients.

Hepatit B Enfeksiyonunda Karaciğer Histopatolojik Evreleri ile Albumin-Bilirubin Skoru Arasındaki İlişki

“…Although sensitivity was 61.1% and specificity was 64.7% for F≥2 in the cut-off value of -2.81, sensitivity was 75.0% and specificity was 72.3% for F≥4 in the cut-off value of -2.78. The results were similar to the results of other studies in the literature (16,36). Our study is important as it is one of the rare studies where the ALBI score results are assessed to predict fibrosis in patients with chronic HBV.…”

“…In one study, which included 217 patients with chronic HBV, the AUROC value of the ALBI score was 0.698 for F≥2, and 0.843 for F≥4. The sensitivity and specificity rates in the cut-off value of >-2.7 were 42.6% and 91% for F≥2, and 70.45% and 86.13% for F≥4, respectively (36). In another study, which included 91 patients with chronic HBV, although the AUROC value of the ALBI score for fibrosis prediction was 0.849, the sensitivity and specificity rates in the cut-off value of -2.19 in distinguishing cirrhotic and non-cirrhotic cases were 85.7% and 74%, respectively (16).…”

The role of serum bile acid profile in differentiation between nonalcoholic fatty liver disease and chronic viral hepatitis

“…Also, hepatitis B virus makes major health problem. Chronic HBV infection may develop cirrhosis and subsequently liver decompensation and hepatocellular carcinoma which is a major drastic complication [10]. Recently, nonalcoholic fatty liver disease is considered the most common cause of liver disease with prevalence of 25% worldwide.…”