Gamma-Glutamyl Transferase

Grundy, Scott M.

doi:10.1161/01.atv.0000253905.13219.4b

Cited by 58 publications

(31 citation statements)

References 59 publications

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“…It has been observed that elevated serum GGT is an independent marker of the activation of systemic inflammation and increased oxidative stress, independent of its relationship with metabolic syndrome 22) . Based on current available data, it has recently been purported that an increase in serum levels of GGT, although within its reference range, is a promising predictor of cardiovascular risk 21,[23][24][25][26] .…”

Section: Pathogenetic Rolementioning

confidence: 99%

Gamma-glutamyltransferase to Determine Cardiovascular Risk: Shifting the Paradigm Forward

Turgut

Tandoğan

2011

JAT

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Gamma-glutamyltransferase (GGT), regarded as a marker of excessive alcohol consumption or liver disturbances, is an enzyme catalyzing the first step in the extracellular degradation of the antioxidant glutathione (GSH) and may take part in atherogenesis. The marked relationship between GGT and the atherosclerotic process has shifted attention to the issue of whether its serum levels can aid in the detection of individuals at high risk for incident cardiovascular events. It is likely that the process entails the oxidation of low-density lipoprotein through GSH/GGT-dependent iron reduction within the plaque. In this context, oxidative stress is a probable mediator. Recent insights into the pathophysiological background of GGT in the precipitation and progression of atherosclerosis appear to be supported by relevant epidemiological observations as a cardiovascular risk predictor. Further understanding is, nevertheless, warranted to ameliorate the prognostic stratification of patients through GGT.

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Section: Pathogenetic Rolementioning

confidence: 99%

Gamma-glutamyltransferase to Determine Cardiovascular Risk: Shifting the Paradigm Forward

Turgut

Tandoğan

2011

JAT

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“…Some researchers interpreted that serum GGT predicts type 2 diabetes because it acts as a pro-oxidant or a marker of hepatic steatosis [12][13][14]. These mechanisms may partly explain some of the associations between GGT and type 2 diabetes, especially those observed at relatively high levels of serum GGT activity.…”

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confidence: 99%

Can persistent organic pollutants explain the association between serum γ-glutamyltransferase and type 2 diabetes?

2007

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The results of several epidemiological studies of serum γ-glutamyltransferase (GGT) led us to hypothesise that associations of GGT within its normal range with type 2 diabetes may reflect detrimental effects of xenobiotics found in the environment, such as persistent organic pollutants (POPs). Epidemiological observations showed that serum GGT activity within its normal range strongly predicted future type 2 diabetes; the predictability of diabetes from obesity was low with GGT at the low end of the normal range; and GGT showed a positive association with known markers of oxidative stress or inflammation. Experimental findings on cellular GGT suggest that serum GGT levels within the normal range may reflect oxidative stress related to the re-synthesis of intracellular glutathione; however, this interpretation is not completely satisfying because, in its role of regenerating intracellular glutathione, GGT activity should be antioxidative.

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“…2 Recently, GGT has been shown to have an active role in oxidative and inflammatory mechanisms as well as atherosclerotic pathogenesis, and thus it can be used as a biomarker to determine risk for cardiovascular diseases. [3][4][5][6] Risk factors for coronary artery diseases and stroke have also been indicated. 7,8 In addition, GGT has a prognostic role in CVD and stroke.…”

Section: Introductionmentioning

confidence: 99%

Can We Use Serum Gamma-Glutamyl Transferase Levels to Predict Early Mortality in Stroke?

Akıncı¹,

Doğan

Gümüş³

et al. 2014

The Journal of Emergency Medicine

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Gamma-Glutamyl Transferase

Cited by 58 publications

References 59 publications

Gamma-glutamyltransferase to Determine Cardiovascular Risk: Shifting the Paradigm Forward

Gamma-glutamyltransferase to Determine Cardiovascular Risk: Shifting the Paradigm Forward

Can persistent organic pollutants explain the association between serum γ-glutamyltransferase and type 2 diabetes?

Can We Use Serum Gamma-Glutamyl Transferase Levels to Predict Early Mortality in Stroke?

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