Gamma Globulin and Complement in the Diseased Kidney

Freedman, Paul D.; Markowitz, A. S.

doi:10.1172/jci104486

Cited by 79 publications

(19 citation statements)

References 10 publications

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“…After standing for 1 hour, the clots were washed with distilled water, lyophilized, and suspended in particulate form in 0.15 M saline. Antisera were also prepared against 5) human albumin (Cohn Fraction V), 6 …”

Section: Methodsmentioning

confidence: 99%

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Acute poststreptococcal glomerulonephritis: immune deposit disease.

Michael¹,

Drummond²,

Good³

et al. 1966

J. Clin. Invest.

249

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Section: Methodsmentioning

confidence: 99%

“…Thin sections (Patients 1 to 4,6,10,12). Although nodular masses seen along the basement membrane of glomerular capillaries of fluorescent and electron microscopy (see below) were not visible in routine 4-,u sections because of thickness of the tissue, these masses could be resolved by light microscopy with thinner sections.…”

Section: I) Light Microscopymentioning

confidence: 99%

Acute poststreptococcal glomerulonephritis: immune deposit disease.

Michael¹,

Drummond²,

Good³

et al. 1966

J. Clin. Invest.

249

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“…The existence of tissue-bound immune complexes has been suggested mainly by immunohistological techniques (6,7), showing the presence of immunoglobulins, complement components, and sometimes antigen in the lesions. More direct techniques led to the demonstration in serum samples of immune complexes involving a previously identified antigen.…”

mentioning

confidence: 99%

Circulating Immune Complexes in the Serum in Systemic Lupus Erythematosus and in Carriers of Hepatitis B Antigen QUANTITATION BY BINDING TO RADIOLABELED Clq

Nydegger¹,

Lambert²,

Gerber³

et al. 1974

J. Clin. Invest.

386

107

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“…The presence of immunoglobulins and complement has been demonstrated in glomerular lesions by immunofluorescence techniques (4)(5)(6)(7), and antinuclear antibodies have been found in eluates from the glomeruli (8)(9)(10)(11). Fluorescein-labeled, highly purified antibody to DNA obtained from the serum of a lupus patient has localized in the glomeruli of two patients with SLE nephritis.…”

mentioning

confidence: 99%

Localization of fluorescein-labeled antinucleoside antibodies in glomeruli of patients with active systemic lupus erythematosus nephritis

Andres¹,

Accinni²,

Beiser³

et al. 1970

J. Clin. Invest.

129

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A B S T R A C T Renal tissues from two groups of patients were studied with fluorescein-labeled (Fl-) antibodies (Abs) to immunoglobulins, complement, and antibodies prepared in rabbits against BSA conjugate of 5-methyluridine (T) and cytidine (C), the latter two of which react specifically with denatured DNA. The first group consisted of 13 SLE patients, and the second consisted of 53 patients with non-SLE nephropathies. The data obtained from the two groups of patients were used for comparison, and they showed the following:(a) Fl-Abs to immunoglobulins and complement were bound in the glomeruli of tissues from all patients with active SLE glomerulonephritis characterized by deposits of foreign material in glomerular capillary walls (GCW). The fluorescent pattern was granular, corresponding to the distribution of the glomerular deposits, as seen by electron microscopy. Fl-Abs reactive with thymine and cytosine were bound in the GCW of eight of the nine patients with active SLE glomerulonephritis and showed the same granular distribution. The capacity of these latter Fl-Abs to stain the GCW was removed by absorption with the homologous antigen or denatured DNA.(b) Fl-Abs to immunoglobulins, complement, and pyrimidine bases of DNA did not react with the GCW of two SLE patients without clinical and histologic evidence of glomerulonephritis or with the sclerotic glomeruli of two uremic patients with chronic "burned out" lupus nephritis.(c) The glomeruli of 47 of the 53 patients with other nephropathies bound Fl-Abs to immunoglobulins and

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Gamma Globulin and Complement in the Diseased Kidney

Cited by 79 publications

References 10 publications

Acute poststreptococcal glomerulonephritis: immune deposit disease.

Acute poststreptococcal glomerulonephritis: immune deposit disease.

Circulating Immune Complexes in the Serum in Systemic Lupus Erythematosus and in Carriers of Hepatitis B Antigen QUANTITATION BY BINDING TO RADIOLABELED Clq

Localization of fluorescein-labeled antinucleoside antibodies in glomeruli of patients with active systemic lupus erythematosus nephritis

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