Acute poststreptococcal glomerulonephritis: immune deposit disease.

The nephrotic syndrome of childhood: immunologic, clinical, and pathologic correlations.

“…Group III constitutes only a relatively small proportion of children with the nephrotic syndrome. However, since the nephrotic syndrome can occur as a manifestation of acute poststreptococal glomerulonephritis (15), and since recent studies have established that immunologic mechanisms are operative in this disease (11,16,17), patients developing the nephrotic syndrome in the course of this disease could be included in this group.…”

“…The albumin,3 and betaic-globulin,4 and in a goat to rabbit gamma globulin.5 The methods used for immunization, antisera preparation, FITC conjugation, tissue sectioning, staining, and microscopic and photographic techniques are described in another publication (11). Antisera to human albumin and to rabbit gamma globulin were used as control stains for the antisera to human IgG and betacglobulin.…”

The glomerular mesangium

“…The mesangial cells occupy an intercapillary position separated from the capillary lumen, internally, by the endothelial cell cytoplasm and bounded externally by the glomerular basement membrane (2). Light, immunopathologic, and electron microscopic observations of the human kidney in a variety of diseases including anaphylactoid purpura nephritis (3), chronic membranoproliferative nephritis with hypocomplementemia (4), diabetic nephropathy (5), acute poststreptococcal nephritis (6), and lupus erythemnatosis (7) have demonstrated significant mesangial alterations. However, at present only very limited knowledge of the function of the mesangial system and its relationship to glomerular pathology is available.…”

Complement in overt and asymptomatic nephritis after skin infection

“…Immunopathologic studies have demonstrated the deposition of products including immunoglobulins, fibrin, and complement in the glomeruli of patients with poststreptococcal AGN (34)(35)(36)(37)(38)(39). However, streptococcal products have been demonstrated in only limited instances (34,36,39). A form of nephritis similar to that seen in man has now been produced in rabbits with nephritogenic strains of streptococci (40).…”