The nephrotic syndrome of childhood: immunologic, clinical, and pathologic correlations.

Drummond, Keith N.; Michael, A F; Good, Robert A.; Vernier, Robert L.

doi:10.1172/jci105376

Cited by 77 publications

(13 citation statements)

References 14 publications

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“…Cytostatic therapy may yield satisfactory results in the nephrotic syndrome, especially if biopsy reveals only minimal glomerular lesion under the light microscope [2,8,21], and if immunohistological examination indicates glomerular fixation of antibodies [10]. It is nevertheless generally agreed that, as a first measure, treatment with steroids should be attempted.…”

Section: Discussionmentioning

confidence: 99%

Immunosuppressive treatment of allergic nephropathies

Hámori

Gofman

Pásztory

et al. 1969

Urology and Nephrology

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Nine patients (three with subacute and six with chronic glomerulonephritis) have been treated with 6-mercaptopurine and azathioprine. The severity of the disease was determined on the evidence of protein excretion, the Addis count and the level of serum complement. The results justify not more than moderate optimism. Cytostatic drugs are applied only if corticosteroid therapy has no effect or is contraindicated~ Peptic ulcer and amyloidosis are absolute, obesity and diabetes relative contraindications of steroid therapy. Epilepsy accompanying collagen disease is not a contlaindication. Subcapsular cataract provoked by steroids makes no further progress if the steroid therapy has to be continued. Steroids, if administered after the 15th year of age, do not impede growth. A combination of cytostatic agents and corticosteroids seems to be lceneficial and is perhaps less dangerous, although a patient developed agranulocytosis after having been treated with a combination of 6-mercaptopurine and prednisolone.

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Section: Discussionmentioning

confidence: 99%

Immunosuppressive treatment of allergic nephropathies

Hámori

Gofman

Pásztory

et al. 1969

Urology and Nephrology

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“…Renal biopsy was performed on all of the patients. The histologic diagnosis of mini mal-change glomerular lesions was made using light, immunofluorescence and electron microscopes based on the reports of Clwrg et al [I], McCluskey et al [2] and Drummond et al [3]. Those patients who had focal glomerulosclerosis were excluded.…”

Section: Methodsmentioning

confidence: 99%

Period of Freedom from Relapse as an Indication of Cure in Minimal Change Nephrotic Syndrome in Adults

Kida¹,

Iida²,

Dohi³

et al. 1977

Nephron

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17 adult-onset nephrotic patients with minimal-change glomerular lesions experienced 39 relapses in all. The relationship between the remission period t (expressed in months) preceding each relapse and the rate of relapse (relapse rate) F(t) was proven to correspond closely to Weibull’s distribution function as follows (χ² = 1.72, 0.5 < p < 0.75): In In 1/1-F(t) = 1.16 In t-2.73. From the equation, the time when 99% of relapsing patients have relapsed is 39.3 months. This means that adult-relapsing nephrotic patients with minimal-change lesions will experience a relapse within 39.3 months of remission. They should be free from relapse and considered cured with a 99% reliability when remission has continued longer than 39.3 months, i. e. beyond the ‘period of freedom from relapse’.

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“…(19) (20). Para algunos autores el ultimo grupo constituiria una entidad separada caracterizada por una glomerulonefritis progresiva y fatal a corto plazo (21) (22) (23).…”

Section: Discusfon Los Mecanismos Inmunologicos De Lesion Renal Ban unclassified

Niveles séricos de IgG., IgM., C³, transferrina y haptoglobina en glomerulonefritis aguda, crónica y síndrome nefrótico en la infancia

Galletti¹,

Melendez²,

Puga³

et al. 1973

Rev. chil. pediatr.

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The nephrotic syndrome of childhood: immunologic, clinical, and pathologic correlations.

Cited by 77 publications

References 14 publications

Immunosuppressive treatment of allergic nephropathies

Immunosuppressive treatment of allergic nephropathies

Period of Freedom from Relapse as an Indication of Cure in Minimal Change Nephrotic Syndrome in Adults

Niveles séricos de IgG., IgM., C³, transferrina y haptoglobina en glomerulonefritis aguda, crónica y síndrome nefrótico en la infancia

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