Background: Smartphone eSports athletes sit in the same posture for a prolong period, contributing to significant health risks. This study investigated the health profile, fatigue, pain and complaints, and musculoskeletal problems among full-time smartphone eSports athletes.Methods: We recruited 50 participants from the ten teams of a top-tier league tournament, with each team for five players. A survey was conducted to evaluate the fatigue pattern, pain level, and complaints. Physical assessment was also conducted by physiotherapists. A descriptive analysis was conducted to evaluate the health profile (BMI, fat ratio), fatigue, number of complaints and musculoskeletal problems. The associations of career duration with BMI, fat ratio, and the total number of confirmed injuries were then performed using a Spearman’s rank correlation test. Results: About 46% and 44% of participants felt tired, while 34% and 58% experienced eyestrain frequently and occasionally. More than 30% of the participants reported headache, neck pain, trigger finger and rhinitis. Physiotherapists confirmed head-and-trunk injuries on 90% of the participants, with a quarter of them suffering at least one of these four pains. Longer career duration of eSports may be associated with a reduction in BMI (r=-0.272, p=0.056). The duration of career has no significant association with smoking habit (p=0.666), alcohol habit (p=0.655), coffee habit (p= 0.946), rounds of game that can maintain concentration (p=0.253), ease of eyestrain (p=0.569), tiredness (p=0.510), dizziness (p=0.071), and leg numbness (p=0.318).Conclusion: The findings of this study stressed the significance of eSports injuries and implicated preventive measures for both athletes and phubbers.