Gallstone Disease and Related Risk Factors in Patients With Crohn Disease

Fraquelli, Mirella; Losco, Alessandra; Visentin, S.; Cesana, Bruno Mario; Pometta, R.; Colli, Agostino; Conte, Dario

doi:10.1001/archinte.161.18.2201

Cited by 73 publications

(62 citation statements)

References 29 publications

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“…1 In particular, the occurrence of gallstone disease (GD) in patients with Crohn's disease (CD) has been investigated in several studies, [2][3][4][5][6][7][8][9][10][11][12] with prevalence rates ranging from 13% to 34%. Unfortunately, many of the aforementioned studies included selected CD patients (such as only those undergoing surgical resection or with disease confined to the terminal ileum), which may explain the great differences of prevalence between series, and others enrolled only limited number of patients, thus limiting the precision of estimates.…”

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confidence: 99%

Incidence and risk factors for gallstones in patients with inflammatory bowel disease: A large case-control study

et al. 2007

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The risk for gallstones (GD) in inflammatory bowel diseases and the factors responsible for this complication have not been well established. We studied the incidence of GD in a cohort of Crohn's disease (CD) and ulcerative colitis (UC) patients and investigated the related risk factors. A case-controlled study was carried out. The study population included 634 inflammatory bowel disease (IBD) patients (429 CD, 205 UC) and 634 age-matched, sex-matched, and body mass index (BMI)-matched controls free of GD at enrollment, who were followed for a mean of 7.2 years (range, 5-11 years).The incidence of GD was calculated by dividing the number of events per person-years of follow-up. Multivariate analysis was used to discriminate among the impact of different variables on the risk of developing GD. The incidence rates of GD were 14.35/1,000 persons/year in CD as compared with 7.

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confidence: 99%

Incidence and risk factors for gallstones in patients with inflammatory bowel disease: A large case-control study

et al. 2007

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“…These findings are consistent with findings of the previous study of Fraquelli M et al in which they recorded a significant relation of increasing age with prevalence of gall bladder stones in 330 cholelethiasis patients. [15] They recorded 51 % prevalence of cholelethiasis in more than 50 years age group patients. Similarly, Volzke H observed in 4202 gall bladder stones patients that cholelethiasis was more common with advancing age.…”

Section: Discussionmentioning

confidence: 97%

Prevalence of Thyroid Disorders in Patients of Gall Bladder Stones: A Prospective Study

Singh¹,

Kaul²,

Singh³

et al. 2018

AIMDR

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Background: Gall bladder stones are one of the commonest abdominal disorder requiring hospitalization and surgery in India. In Europian countries more than 10% prevalence of gall bladder stone has been recorded. Different studies suggested that sluggish movement of bile during hypothyroidism may induce formation of stone in gall bladder. Moreover, use of thyroxine for dissolving gall bladder stone has been suggested in studies. However, relation of thyroid hormones and gall bladder stone is still unclear. Therefore, present study was designed to assess if there is any relation between thyroid hormones disorders and gall bladder stones. Methods: It was cross sectional type of study which was conducted in departments of general surgery of TMMC & RC, Moradabad. This study was carried out from April 2017 to December 2017. Study population included 100 patients of cholelithiasis undergoing for cholecystectomy. Surgical profile along with full history including name, age, sex etc was recorded in the study. Similarly, full history of control group subjects was taken. Thyroid hormones in serum total tri iodothyronine (T3), free thyroxine (FT4), and TSH were measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Results: Gall bladder stone were more common in female patients (60) in comparison of male patients (40). Hypothyroid disorder was found in 20% male gall bladder patients. Whereas, 7.5% hyperthyroid disease in male cholelethiais patients. Euthyroid status was observed in 72.5% male gall bladder patients. Hypothyroid disorder was found in 14% female gall bladder patients. Whereas, 7% hyperthyroid disease in female cholelethiais patients. Euthyroid status was observed in 65% female gall bladder patients. Conclusion: Findings of the current study suggest that female population suffers more in comparison of male population. Further, prevalence of gall bladder stones were more in 51 to 60 years age group population. Further, no definite relation was observed between thyroid hormones disorders either hypothyroid or hyperthyroid and gall bladder stones. However, more studies of on larger populations are required to assess if there is any relation between thyroid disorders and gall bladder stones.

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“…UC (which does not involve the small bowel) is not considered a risk factor for cholelithiasis. Patients with ileo-colonic CD are at increased risk of cholelithiasis when compared to CD patients with only the ileal involvement [153][154][155]. Past history of intestinal resections and the number of resections have also been implicated as risk for the development of cholelithiasis [26,[152][153][154][155].…”

Section: Cholelithiasismentioning

confidence: 99%

“…Patients with ileo-colonic CD are at increased risk of cholelithiasis when compared to CD patients with only the ileal involvement [153][154][155]. Past history of intestinal resections and the number of resections have also been implicated as risk for the development of cholelithiasis [26,[152][153][154][155]. Ileal involvement (either resection or inflammation) with decreased bile salt absorption leading to lithogenic super saturated bile is considered the main mechanism for the development of cholelithiasis in this sub-group [156,157].…”

Section: Cholelithiasismentioning

confidence: 99%

A review of liver disorders in inflammatory bowel disease (IBD)

Shah¹,

Gupta²,

Borg³

2017

Clin Case Rep Rev

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Disorders of the liver and the biliary tract are frequently the extraintestinal manifestations of inflammatory bowel disease (IBD). The etiology of these hepato-biliary conditions is deemed secondary to their shared pathogenesis, the chronic effects of a long term, ongoing inflammation of the bowels, along with the medications used to manage IBD. For up to 30% of patients with IBD, abnormal liver biochemical tests are present. Other, selected patients with IBD are followed for reactivation of hepatitis B, through guidelines only relatively recently in place. The vast realm of related clinical conditions does not always correspond well with IBD severity, which can range from mild hepatic insult to end-stage liver disease, necessitating liver transplantation. Hence it is critical to follow its presence, clinical course and long term consequences. Moreover, the management of these disorders is necessarily individualized, with some patients requiring frequent monitoring and others a more multi-disciplinary approach. Studies aimed at improving the outcomes of patients with IBD who experience associated liver and biliary tract disorders are now needed to assess early identification, possible screening approaches and more effective systems of referral. This article covers the evidence-based literature on topics detailing the co-existence of liver conditions in inflammatory bowel disease with a focus on its epidemiology, clinical manifestations, diagnosis and management.

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Gallstone Disease and Related Risk Factors in Patients With Crohn Disease

Cited by 73 publications

References 29 publications

Incidence and risk factors for gallstones in patients with inflammatory bowel disease: A large case-control study

Incidence and risk factors for gallstones in patients with inflammatory bowel disease: A large case-control study

Prevalence of Thyroid Disorders in Patients of Gall Bladder Stones: A Prospective Study

A review of liver disorders in inflammatory bowel disease (IBD)

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