Gallstone, cholecystectomy and risk of gastric cancer

Kang, Sung-Hwa; Kim, Young Hoon; Roh, Young Hoon; Kim, Kwan Woo; Choi, Chan Joong; Kim, Min Chan; Kim, Su Jin; Kwon, Hee Jin; Cho, Jin Han; Jang, Jin Seok; Lee, Jong-Hun

doi:10.14701/ahbps.2017.21.3.131

Cited by 23 publications

(25 citation statements)

References 26 publications

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“…Moreover, our study is in agreement with the study from Shabanzadeh et al, to show that cholecystectomy cannot diminish the risk of prostate cancer [34]. Cholecystectomy has been shown to be capable of increasing the serum levels of cholecystokinin and secretin, and it is suggested to measure their serum levels before and after the removals of gallstones to ascertain whether this alteration is related to increased risk of prostate cancer [35,36].…”

Section: Discussionsupporting

confidence: 92%

Association of Cholecystectomy with the Risk of Prostate Cancer in Patients with Gallstones

Chen

Lin

Kao

2020

Cancers

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Objectives: To assess the association of cholecystectomy with the risk of prostate cancer in patients with gallstones. Methods: This nationwide population-based cohort study was conducted by retrieving the Longitudinal Health Insurance Research Database (LHID2000) for inpatient claims in the Taiwan National Health Insurance (NHI) program. The study cohort consisted of 72,606 men aged ≥ 20 years with gallstones undergoing cholecystectomy between 2000 and 2010. The control cohort consisted of the men with gallstones, but without cholecystectomy, by 1:1 propensity score matching with the study cohort based on age, sex, urbanization, occupation, comorbidities, and the index date. We compared the hazard ratio of prostate cancer between both of the cohorts. Results: The incidence of prostate cancer was 0.76/1000 person-years for the non-cholecystectomy cohort and 1.28/1000 person-years for the cholecystectomy cohort [aHR (adjusted hazard ratio) = 1.67, 95% confidence interval (CI = 1.45–1.92), respectively (p < 0.001). When compared with the non-cholecystectomy cohort, the hazard ratio of prostate cancer for the cholecystectomy cohort was 1.49-fold greater (95% CI = 1.04–2.11) for follow-up ≤ 1 year, 1.52-fold greater (95% CI = 1.24–1.86) for follow-up 1–5 years, and 1.99-fold greater (95% CI = 1.56–2.53) for follow-up > 5 years, respectively. Conclusions: Cholecystectomy is associated with an increased hazard ratio of prostate cancer in gallstones patients, and the risk increases with an incremental period of follow-up. This observational study cannot ascertain the detrimental mechanisms of cholecystectomy for the development of prostate cancer, and cholecystectomy is not recommended for the prevention of prostate cancer based on our study.

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Section: Discussionsupporting

confidence: 92%

Association of Cholecystectomy with the Risk of Prostate Cancer in Patients with Gallstones

Chen

Lin

Kao

2020

Cancers

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“…29 Similarly in a study of 99 patients; Kang et al, reported increased association of gall stones and cholecystectomy with stomach cancers. 30 The relationship between intra and extra hepatic cholangiocarcinoma and cholecystectomy is still not clear due to sparse literature and controversial results. In the past studies cholecystectomy was seen to be associated with decreased risk of cholangiocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Signet ring cell cholangiocarcinoma in a patient previously operated for cholecystectomy: is there any connecting link?

et al. 2019

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Cholangiocarcinoma are malefic tumours of bile duct. Signet ring cell carcinoma (SRCC) is rare entity. Several risk factors have been attributed to its ethology, the main overriding link between two being chronic inflammation of the bile system. Cholecystectomy has also been a proposed risk factor. This study was undertaken in Department of Pathology at LLRM Medical College, Meerut. A 49 years old female, operated for cholecystectomy 1.5 year back in same hospital, now presented with chief complains of jaundice and abdominal discomfort. The blood chemistry revealed increased total bilirubin (13.7 mg/dl), Alkaline phosphatase (877.6 IU/L), Carbohydrate Antigen (CA) 199(184 U/ml) and Carcinoembryonic antigen (CEA) (14.5 ng/ml). Computed Tomography (CT) showed a stricture in mid Common bile duct (CBD). Excision of stricture was done using retrocholic hepatico-jejunostomy. Tissue was submitted for histopathology. Histopathological assessment showed SRCC. The patient failed to turn up for further management but returned back after a span of time presenting with gross ascites and pallor ultimately leading to death within 12 weeks of diagnosis. This was the first case of SRCC to arise in a patient who had a previous history of cholecystectomy. Whether there is some connecting link between the two is still not clear. Further studies are warranted in this direction to establish cholecystectomy as an etiological factor for cholangiocarcinoma.

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“…Our results were not consistent with the report showed the worse survival at the greater curvature location than lesser curvature of the gastric cancer. (32) In our study, we investigated the expression status of several tumor markers which are closely related with clinicopathologic characteristic and prognosis in GC, and are commonly used in the current clinic. But except for EGFR, none of them were found statically different expression between lesser curvature and larger curvature.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological difference of gastric cancer between lesser and greater curvature

Li¹,

Zhao

Zhang

et al. 2019

Preprint

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Background: Gastric cancer(GC) is heterogeneous disease, recent years has established a molecular classification and described distribution of molecular subtypes in stomach. However, the clinicopathological difference of gastric cancer between lesser and greater curvature is still unknown. In this study, we investigated the clinicopathological difference of gastric cancer between lesser and greater curvature. Methods: Between January 2010 and August 2014, 1249 consecutive patients with GC located at lesser or greater curvature were treated in our surgery department, the data of demographic, pathological type, differentiation, tumor size, TNM stage, tumor markers, operative methods, complications and follow-up data were analyzed by univariant analysis and Kaplan-Meier analysis retrospectively. Results: We found the tumor size in lesser curvature was larger than in greater curvature (4.95±2.57 vs. 4.43±2.62cm, P=0.034); The patients with gastric cancer in lesser curvature had a higher incidence of total gastrectomy, but a lower incidence of distal gastrectomy than it in greater curvature (60.2% vs. 43.2%, and 34.8% vs. 49.2%, P=0.002); The 5-year survival rate of gastric cancer between the curvatures was not statically significant (62.6±0.02% vs.66.1±0.06%, P=0.496); The rate of EGFR expression in lesser curvature was 40.55%, which was significantly higher than that in greater curvature (25.92%，P=0.024), and the 5-year survival rate in patients with EGFR positive was 50.8±0.06%, which was significantly lower than that in patients with EGFR negative (64.8±0.03%，P=0.021). Conclusions: Our results suggest that the clinicopathological difference of gastric cancer is significant between lesser and greater curvature. Emphasizing the difference contribute to improve outcome of treatment.

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Gallstone, cholecystectomy and risk of gastric cancer

Cited by 23 publications

References 26 publications

Association of Cholecystectomy with the Risk of Prostate Cancer in Patients with Gallstones

Association of Cholecystectomy with the Risk of Prostate Cancer in Patients with Gallstones

Signet ring cell cholangiocarcinoma in a patient previously operated for cholecystectomy: is there any connecting link?

Clinicopathological difference of gastric cancer between lesser and greater curvature

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