Galloylated flavonol rhamnosides from the leaves of Calliandra tergemina with antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)

Chan, Elaine Wan Ling; Gray, Alexander I.; Igoli, John O.; Lee, Sui Mae; Goh, Joo Kheng

doi:10.1016/j.phytochem.2014.07.028

Cited by 17 publications

(15 citation statements)

References 18 publications

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“…The conclusions from the obtained results in the present study were similar to the ones recorded by Chan et al [31] The author evaluated the antibacterial activities against MRSA. [31] In the study galloylated flavonol rhamnosides and quercetin, together with five known galloylated and non-galloylated flavonol rhamnosides, isolated from leaves of Calliandra tergemina (L.) Benth, were used as antibacterial agents against MRSA.…”

Section: Molecular Diversity and Phylogenysupporting

confidence: 91%

“…[31] In the study galloylated flavonol rhamnosides and quercetin, together with five known galloylated and non-galloylated flavonol rhamnosides, isolated from leaves of Calliandra tergemina (L.) Benth, were used as antibacterial agents against MRSA. [31] By using the PCR method, all of the 44 tested isolates in the present study were found to be positive for mecA gene and also resistant to all classical microbiology diagnostic methods. This showed a good relationship between the molecular and classical approaches for the detection and diagnosis of such organisms and may also encourage the replacement of the classical methods with the faster and more accurate molecular approaches.…”

Section: Molecular Diversity and Phylogenymentioning

confidence: 99%

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The effect ofRhazya strictaaqueous leaves extract on MRSA genotypes in Jeddah province

Baeshen

Al-Attas

Ahmed

et al. 2016

Biotechnology & Biotechnological Equipment

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Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that is resistant to a large group of beta-lactam antibiotics. Rhazya stricta is a local shrub that grows naturally as a normal flora and is used as a medicinal plant by several nations for a lot of infectious diseases, caused by microorganisms. Therefore, the effect of the plant against different genotypes of methicillinresistant S. aureus was tested in the present study. Molecular identification was done for the medical sampling of 44 MRSA and biodiversity approaches were applied to detect the mecA gene. The 16S rRNA genes analysis was performed for the construction of a phylogenetic tree. Later on, the antimicrobial effect of the plant leaves' water extract was tested on different genotypes. MecA gene appeared in all isolates, except in methicillin-susceptible Staphylococcus aureus. The selected MRSA 16S rRNA sequences were sent to GenBank and six accession numbers (KM893010, KM893011, KP091274, KP091275, KP137513 and KP137514) were acquired. Also, an evolutionary analysis of these strains was done and a phylogenetic tree was constructed. Plant extracts showed that the interaction between pathogens and drugs is more efficient in a liquid environment than in a solid one.

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Section: Molecular Diversity and Phylogenysupporting

confidence: 91%

Section: Molecular Diversity and Phylogenymentioning

confidence: 99%

The effect ofRhazya strictaaqueous leaves extract on MRSA genotypes in Jeddah province

Baeshen

Al-Attas

Ahmed

et al. 2016

Biotechnology & Biotechnological Equipment

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“…encapsulating the fluorescent probe carboxyfluorescein and detected the perturbation of bacterial membranes by those catechins. Chan et al (2014) found that flavonol rhamnoside derivatives isolated from leaves of Calliandra tergemina (L.) Benth. showed antibacterial activities against MRSA.…”

Section: Crude Aqueous Extractmentioning

confidence: 99%

Phytochemical analysis and assessment of antioxidant, antimicrobial, anti-inflammatory and cytotoxic properties of Tetraclinis articulata (Vahl) Masters leaves

Rached

Zeghada

Bennaceur

et al. 2018

Industrial Crops and Products

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Tetraclinis is an unexplored genus recognized for its great bioactive potential that could be explored as a medicinal herb. The aim of this study was to evaluate the antioxidant, antibacterial, anti-inflammatory and cytotoxic properties of the aqueous crude extract and subsequent organic fractions of the Algerian medicinal plant T. articulata. Moreover, polyphenols were also fully profiled by liquid chromatography with diode-array detection coupled to electrospray ionization in tandem with mass spectrometry (LC-DAD-ESI-MS n). The analysis of the obtained results show that B-type (epi)catechin dimer and catechin were the most abundant phenolic compounds present among the nine different flavonoids identified such as: ((epi)catechin, myricetin, quercetin and kaempferol glycoside derivatives). The concentration of phenolic compounds in the ethyl acetate fraction (93.1 mg/g extract) was higher than the one of the aqueous extract (21.2 mg/g extract) and butanol fraction (43.87 mg/g extract). Furthermore, the ethyl acetate fraction revealed the strongest bioactive properties, revealing the lowest EC 50/ GI 50 values: anti-inflammatory (EC 50, 129.67 μg/mL), cytotoxicity against human tumor cell lines (GI 50 , 59-189 μg/mL), antibacterial (MIC, 0.625-10 mg/mL); and especially the antioxidant capacity (EC 50 values lower than 12.7 μg/mL), even higher than the standard (Trolox). The results showed a great bioactive potential for this species, with a significant contribution of flavonoid compounds, which makes it an interesting matrix in the development of novel pharmaceutical formulations.

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“…The attachment of one or more sugar units to different positions of a flavonoid compound can increase its solubility and influence the biological activity of the compound, often increasing its antioxidant and other potential medicinal properties (Chan et al , 2014; Ghanadian et al , 2012; Jones & Vogt, 2001; Kondratyuk & Pezzuto, 2004). Glycosylation is a frequently occurring modification reaction; such reactions are often the last step in the biosynthesis of particular flavonoids.…”

Section: Introductionmentioning

confidence: 99%

Involvement of three putative glucosyltransferases from the UGT72 family in flavonol glucoside/rhamnoside biosynthesis inLotus japonicusseeds

Yin

Shen

Chang

et al. 2016

EXBOTJ

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Galloylated flavonol rhamnosides from the leaves of Calliandra tergemina with antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)

Cited by 17 publications

References 18 publications

The effect ofRhazya strictaaqueous leaves extract on MRSA genotypes in Jeddah province

The effect ofRhazya strictaaqueous leaves extract on MRSA genotypes in Jeddah province

Phytochemical analysis and assessment of antioxidant, antimicrobial, anti-inflammatory and cytotoxic properties of Tetraclinis articulata (Vahl) Masters leaves

Involvement of three putative glucosyltransferases from the UGT72 family in flavonol glucoside/rhamnoside biosynthesis inLotus japonicusseeds

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