Gallotannins Inhibit Growth, Water-insoluble Glucan Synthesis, and Aggregation of Mutans Streptococci

Wu-Yuan, C D; Chen, C.Y.; Wu, Ren‐Chin

doi:10.1177/00220345880670011001

Cited by 158 publications

(119 citation statements)

References 21 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…6,[8][9][10] Gallotannins have been reported to inhibit the growth of a broad spectrum of bacterial species 29 through a variety of mechanisms including binding cell surface molecules including lipoteichoic acid and proline-rich cell surface proteins, 30,31 and by inhibiting glucosyltransferase enzymes. 32 Ellagitannins have also been reported to exert antibacterial activity via several mechanisms including interaction with cytoplasmic oxidoreductases and by disrupting bacterial cell walls. 29,31 It is likely that other phytochemical classes also contribute to the growth inhibitory properties of these extracts.…”

Section: Discussionmentioning

confidence: 99%

Investigating the Pharmacognostic Potential of Indian Terminalia Spp. in the Treatment and Prevention of Yersiniosis

Wright¹,

Greene²,

Cock³

2017

View full text Add to dashboard Cite

Introduction: Yersinia enterocolitica is a major cause of food poisoning through contaminated meat products, causing the acute gastrointestinal disease yersiniosis. Many Terminalia spp. have documented therapeutic properties as general antiseptics, inhibiting the growth of a wide variety of bacterial species. Despite this, Indian Terminalia spp. extracts have not been tested for the ability to inhibit the growth of Y. enterocolitica. Methods: T. arjuna, T. catappa and T. chebula extracts were extracted by maceration and the extracts were investigated by disc diffusion assay for growth inhibitory activity against a clinical strain of Y. enterocolitica. The MIC values of the extracts were determined to quantify and compare their efficacies. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: T. chebula fruit extracts displayed potent growth inhibitory activity in the disc diffusion assay against Y. enterocolitica. The methanolic and ethyl acetate T. chebula fruit extracts were particularly potent growth inhibitors, with MIC values of 85 and 64 µg/mL respectively. The aqueous fruit extract also displayed good growth inhibitory activity against Y. enterocolitica, albeit with a higher MIC value (653 µg/mL). The T. arjuna branch extract was moderately active (3000 µg/mL). All other extracts were either low efficacy, or completely devoid of growth inhibitory activity. All Indian Terminalia spp. extracts were nontoxic (LC 50 values <1000 µg/mL) in the Artemia franciscana bioassay. Conclusions: The lack of toxicity and the potent growth inhibitory bioactivity of the T. chebula extracts against Y. enterocolitica indicates their potential as medicinal agents in the treatment and prevention of yersiniosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigating the Pharmacognostic Potential of Indian Terminalia Spp. in the Treatment and Prevention of Yersiniosis

Wright¹,

Greene²,

Cock³

2017

View full text Add to dashboard Cite

show abstract

“…Gallotannins inhibit the growth of a broad spectrum of bacterial species 44 through a variety of mechanisms including binding cell surface molecules including lipotoichoic acid and proline-rich cell surface proteins, 45,46 and by inhibiting glucosyltransferase enzymes. 47 Elligitannins are also highly potent inhibitors of bacterial growth, with MIC values as low as 62.5 µg/ml. 44,46 Ellagitannins have also been reported to function via several antibiotic mechanisms including interaction with cytoplasmic oxidoreductases and by disrupting bacterial cell walls.…”

Section: Discussionmentioning

confidence: 99%

Growth Inhibitory Activity of Selected High Antioxidant Australian Syzygium Species Against the Food Poisoning and Tissue Necrotic Pathogen Clostridium Perfringens

Wright¹,

Lee²,

Pollock³

et al. 2016

View full text Add to dashboard Cite

Introduction: Clostridium perfringens is a gram positive pathogen which is an etiological agent in Clostridial myonecrosis and enteritis necroticans. Unless promptly treated, C. perfringens infections may result in tissue necrosis and death. Syzygium australe (brush cherry) and Syzygium luehmannii (riberry) fruit and leaves have documented therapeutic properties as general antiseptic agents against an extensive panel of bacteria. Despite this, studies are yet to test the growth inhibitory activity of these species against C. perfringens. Methods: S. australe and S. luehmannii fruit and leaf extracts were investigated by disc diffusion assay for growth inhibitory activity against a clinical strain of Clostridium perfringens. Their MIC values were determined to quantify and compare their efficacies. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: Methanolic and aqueous S. australe and S. luehmannii fruit and leaf extracts as well as the corresponding fruit ethyl acetate extracts, displayed growth inhibitory activity in the disc diffusion assay against C. perfringens. The aqueous and methanolic extracts were particularly potent growth inhibitors, each with MIC values substantially <500 µg/mL. The S. australe fruit extracts were nontoxic in the Artemia franciscana bioassay (LC 50 values <1000 µg/mL). All ethyl acetate extracts were also nontoxic. In contrast, the S. luehmannii aqueous and methanolic extracts (fruit and leaf), as well as the S. australe leaf extracts displayed substantial toxicity in the assay. Conclusion: The potent growth inhibitory bioactivity of the fruit and leaf aqueous and methanolic Syzygium spp. extracts against C. perfringens indicates their potential as medicinal agents in the treatment and prevention of clostridial myonecrosis and enteritis necroticans.

show abstract

“…Gallotannins have been reported to inhibit the growth of a broad spectrum of bacterial species 37 through a variety of mechanisms including binding cell surface molecules including lipotoichoic acid and prolinerich cell surface proteins, 38,39 and by inhibiting glucosyltransferase enzymes. 40 Elligitannins are also highly potent inhibitors of bacterial growth, with MIC values as low as 62.5 µg/ml. 37,39,41 Ellagitannins have also been reported to function via several antibiotic mechanisms including interaction with cytoplasmic oxidoreductases and by disrupting bacterial cell walls.…”

Section: Discussionmentioning

confidence: 99%

Growth inhibition of the zoonotic bacteria Bacillus anthracis by high antioxidant Australian plants: New leads for the prevention and treatment of anthrax

Wright¹,

Matthews²,

Greene³

et al. 2015

Phcog Commn.

View full text Add to dashboard Cite

Introduction: Anthrax is severe acute disease caused by Bacillus anthracis infections. If untreated, it often results in mortality. High antioxidant plant extracts have documented therapeutic properties as general antiseptics, inhibiting the growth of a wide variety of bacterial species. This study examines the ability of selected high antioxidant Australian plant extracts to inhibit B. anthracis growth. Methods: Solvent extracts were prepared using various high antioxidant Australian fruits and herbs and investigated by disc diffusion assay for the ability to inhibit the growth of an environmental strain of B. anthracis. Their MIC values were determined to quantify and compare their efficacies. Toxicity was determined using the Artemia franciscana nauplii bioassay. The most potent extracts were analysed by non-targeted HPLC-QTOF mass spectroscopy (with screening against 3 compound databases) for the identification and characterisation of individual components in crude plant extracts. Results: Methanolic and aqueous extracts of several high antioxidant plant extract sdisplayed potent antibacterial activity in the disc diffusion assay against B. anthracis. The aqueous and methanolic extracts of lemon aspen, as well as the methanolic extracts of muntries, Illawarra plum and native tamarind were particularly potent growth inhibitors with MIC values<1000 µg/mL. Furthermore, all of these extracts were nontoxic in the Artemia fransiscana bioassay, with LC50 values substantially>1000 µg/mL. Non-biased phytochemical analysis of the lemon aspen aqueous and methanolic extracts putatively identified 85 compounds and highlighted several that may contribute to the ability of these extracts to inhibit the growth of B. anthracis. Conclusion: The low toxicity of several high antioxidant plant extracts and their potent inhibitory bioactivity against B. anthracis indicates their potential as medicinal agents in the treatment and prevention of anthrax. Lemon aspen is particularly worthy of further study.

show abstract

Gallotannins Inhibit Growth, Water-insoluble Glucan Synthesis, and Aggregation of Mutans Streptococci

Cited by 158 publications

References 21 publications

Investigating the Pharmacognostic Potential of Indian Terminalia Spp. in the Treatment and Prevention of Yersiniosis

Investigating the Pharmacognostic Potential of Indian Terminalia Spp. in the Treatment and Prevention of Yersiniosis

Growth Inhibitory Activity of Selected High Antioxidant Australian Syzygium Species Against the Food Poisoning and Tissue Necrotic Pathogen Clostridium Perfringens

Growth inhibition of the zoonotic bacteria Bacillus anthracis by high antioxidant Australian plants: New leads for the prevention and treatment of anthrax

Contact Info

Product

Resources

About