Gallium nitride is biocompatible and non-toxic before and after functionalization with peptides

Jewett, Scott A.; Makowski, Matthew S.; Andrews, Benjamin; Manfra, Michael J.; Ivanisevic, Albena

doi:10.1016/j.actbio.2011.09.038

Cited by 129 publications

(102 citation statements)

References 44 publications

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“…Additionally, GaN is non-toxic, an important consideration for distributed applications such as automobile waste heat recovery. 8 The potential of III-nitride materials for thermoelectric applications has motivated increasing research on the experimental properties of GaN, 9,10 InGaN, 3,5,11,12 InAlN, [13][14][15] and AlInGaN 16,17 as well as III-nitride based thermoelectric devices. 18 There have also been a few attempts to calculate and predict the properties of these materials, most notably the thermoelectric properties of GaN, 4 AlGaN, 4,19 and InGaN.…”

Section: Introductionmentioning

confidence: 99%

Calculated thermoelectric properties of InxGa1−xN, InxAl1−xN, and AlxGa1−xN

Sztein

Haberstroh

Bowers

et al. 2013

Journal of Applied Physics

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The thermoelectric properties of III-nitride materials are of interest due to their potential use for high temperature power generation applications and the increasing commercial importance of the material system; however, the very large parameter space of different alloy compositions, carrier densities, and range of operating temperatures makes a complete experimental exploration of this material system difficult. In order to predict thermoelectric performances and identify the most promising compositions and carrier densities, the thermoelectric properties of InxGa1−xN, InxAl1−xN, and AlxGa1−xN are modeled. The Boltzmann transport equation is used to calculate the Seebeck coefficient, electrical conductivity, and the electron component of thermal conductivity. Scattering mechanisms considered for electronic properties include ionized impurity, alloy potential, polar optical phonon, deformation potential, piezoelectric, and charged dislocation scattering. The Callaway model is used to calculate the phonon component of thermal conductivity with Normal, Umklapp, mass defect, and dislocation scattering mechanisms included. Thermal and electrical results are combined to calculate ZT values. InxGa1−xN is identified as the most promising of the three ternary alloys investigated, with a calculated ZT of 0.85 at 1200 K for In0.1Ga0.9N at an optimized carrier density. AlxGa1−xN is predicted to have a ZT of 0.57 at 1200 K under optimized composition and carrier density. InxAl1−xN is predicted to have a ZT of 0.33 at 1200 K at optimized composition and carrier density. Calculated Seebeck coefficients, electrical conductivities, thermal conductivities, and ZTs are compared with experimental data where such data are available.

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Section: Introductionmentioning

confidence: 99%

Calculated thermoelectric properties of InxGa1−xN, InxAl1−xN, and AlxGa1−xN

Sztein

Haberstroh

Bowers

et al. 2013

Journal of Applied Physics

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“…While Cd 2+ ions released from CdSe quantum dots are highly cytotoxic, polymer coated or ZnS shell quantum dots significantly improve biocompatibility [34]. Gallium nitride is an emerging biocompatible semiconductor for use with neural interfaces [35]. In a recent study, silicon transistors, InGaN, and AlInGaP semiconductor LEDs integrated on low modulus silicone substrates had minimal cytotoxicity and no immunogenicity after four weeks of subcutaneous im-plantation in mice [36].…”

Section: Biocompatible and Biodegradable Materialsmentioning

confidence: 99%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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“…They are nontoxic and biofriendly and can be easily attached with graphene due to hexagonal unit cell structures. Recently, Makowski et al [18] have demonstrated GaN can be used for the detection of hexylamine and peptide. To the best of the authors' knowledge, the potential of nitrides for active Ag metal in the SPR sensor keeping in mind high sensitivity at ambient temperatures and high field enhancement at analyte region has not been analysed.…”

Section: Introductionmentioning

confidence: 99%

Effect of Semiconductor on Sensitivity of a Graphene-Based Surface Plasmon Resonance Biosensor

2015

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In this theoretical study, the effect of semiconductor on sensitivity of a graphene-based surface plasmon resonance (SPR) biosensor has been presented. Different semiconductors such as silicon (Si), germanium (Ge) and wurtzite III-V nitrides (AlN, GaN and InN) have been placed in between active silver (Ag) metal and graphene layer. Our simulation result shows that addition of semiconductor layer enhances the sensitivity by a factor of 3.76, 2.19, 3.82, 3.94 and 4.17 respectively for Si, Ge, InN, GaN and AlN. Also, we have examined the field enhancement factor due to above semiconductors and found maximum field intensity enhancement for the case of AlN. The analysis shows that best performance is achieved for red He-Ne laser light when optimized thicknesses of silver, AlN and graphene layer are 55, 14 and 0.34 nm (monolayer of graphene), respectively. More specifically, AlN would be a better choice for biosensing application in SPR biosensor.

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Gallium nitride is biocompatible and non-toxic before and after functionalization with peptides

Cited by 129 publications

References 44 publications

Calculated thermoelectric properties of InxGa1−xN, InxAl1−xN, and AlxGa1−xN

Calculated thermoelectric properties of InxGa1−xN, InxAl1−xN, and AlxGa1−xN

Toward biomaterial-based implantable photonic devices

Effect of Semiconductor on Sensitivity of a Graphene-Based Surface Plasmon Resonance Biosensor

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