Gallic acid: Molecular rival of cancer

Verma, Subhash; Singh, Amit; Mishra, Abha

doi:10.1016/j.etap.2013.02.011

Cited by 289 publications

(191 citation statements)

References 159 publications

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“…Gallic acid has also induced apoptosis of colon adenocarcinoma cells [31]. On the other hand, gallic acid has also dose dependent pro-oxidant activity together with metals [32]. In accordance with this, in our results, H5 triggered expressions of SOD slightly more than H10 in healthy cells while the others were statistically equal.…”

Section: Discussionsupporting

confidence: 81%

Anticancer activity of the “Hardaliye” on HT-29 Cell Line and proliferative activity on CF-1 cell line: Apoptosis and Antioxidant pathway responsive gene expressions

Kahraman-Ilıkkan¹,

Doğanlar²,

Doğanlar³

et al. 2017

Integr Mol Med

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The study was designed to detect anticancer activity and proliferative effect of the Hardaliye in HT-29 and CF-1 cell lines, respectively. Based on MTT results, two dilutions namely, five (H5) and ten-fold (H10) were selected for further analyses. Apoptosis and antioxidant pathway related gene expression levels were detected using qRT-PCR and tali apoptosis assay was used to screen percentage levels of death, apoptotic and viable cells after 24h and 48h of treatment.Results suggested that Hardaliye was effective on cancer cells and trigger apoptosis via increase of Bax (22.45 ± 3.1-fold for H5 and 6.49 ± 0.1-fold for H10) as well as SOD and CAT activity. However, Hardaliye also affected slightly healthy cells when diluted fivefold, though, did not affect when dilute tenfold. According to gene expression levels, an increase at antioxidant enzyme and apoptosis inhibitors was seen after 24 h. On the other hand, antioxidant enzymes apart from GpX of H5, decreased after 48h. Predictably, antioxidant substances of Hardaliye revealed an antioxidant activity over time.Overall, this was the first report considering anticancer activity of Hardaliye besides its efficacy on healthy cells. In this respect, these preliminary results can indicate potential of Hardaliye as a food support in preventing colon cancer.

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Section: Discussionsupporting

confidence: 81%

Anticancer activity of the “Hardaliye” on HT-29 Cell Line and proliferative activity on CF-1 cell line: Apoptosis and Antioxidant pathway responsive gene expressions

Kahraman-Ilıkkan¹,

Doğanlar²,

Doğanlar³

et al. 2017

Integr Mol Med

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“…Phenolic acid has a strong anti-inflammatory, antimutagenic, and antitumor action, inhibiting genes related to the cell cycle, metastasis, angiogenesis, and apoptosis (Verma et al, 2013). The detection of three types of flavonoids, catechin, naringin, and quercetin, in the L. sidoides plant ( Figure 2B) also allows presenting and confirm the possibility of harnessing its leaves for biological applications.…”

Section: Discussionmentioning

confidence: 88%

Secondary metabolites from endophytic fungus from Lippia sidoides Cham.

Ferreira¹,

Santos²,

Soares³

et al. 2017

J. Med. Plants Res.

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Lippia sidoidesCham. (Verbenaceae) is a species native to the Brazilian northeast, widely used in popular medicine. Its leaves were used for the isolation of endophytic fungi and extraction of metabolites. Among them, three were selected according to fungitoxicity tests against the maize phytopathogenic fungus, Curvularia lunata (Wakker). However, the objective of this study was to identify the role of L. sidoides extracts associated with their endophytic fungi, necessary to reduce excess of fungicides applied on the maize crop. Metabolites were evaluated for antioxidant activity by 2.2-diphenyl-1-picrylhydrazyl (DPPH), phenols, total flavonoids and one of it endophytic fungus were evaluated for synergism (Verticilium sp. and plant extracts). The endophytic fungi and plant extracts evaluated for phenolic content ranged from 0.29 ± 0.05 to 96.94 ± 11.86 mgEAG/g, the content of flavonoids from 14.31 ± 1.56 to 192.33 ± 4.58 mgER/g, and antioxidant activity could only be observed for the plant extract with EC 50 81 ± 0.3%. The secondary metabolites identified by HPLC in the plant extract were catechin, quercetin, gallic acid and naringin. Naringenin, catechin, epigallocatechin gallate and quercetin were identified in the extract of the fungi viz. Verticillium sp. and Fusarium sp. Synergistic analysis between a 1:1 proportion of plant and fungal extracts has shown more efficient (79.0%) inhibition of C. lunata. Thus, alternative control of phytopathogenic fungi can be accomplished using plant extracts associated with their endophytic fungi, reducing the excess of fungicides applied on the maize crop.

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“…Hu (2011) reported that pro-oxidant activity can be demonstrated by small phenolics, such as gallic acid, which are easily oxidized and thereby mobilize cellular copper ions or decrease cellular-reduced glutathione. Gallic acid has been identified as both a pro-oxidant and an antioxidant that could cause a dose-dependent reduction of the intracellular GSH level (Verma et al 2013;Chang et al 2015). Furthermore, as most xenobiotics, polyphenols also undergo phase I and II metabolism.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of yellow tea extract on N-nitrosodiethylamine-induced liver carcinogenesis

Kujawska

Ewertowska

Adamska

et al. 2016

Pharmaceutical Biology

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Context Yellow tea containing the same catechins as other types of tea but in different proportions has been suggested to possess potent anticancer activities. Objective This study investigates the chemopreventive effect of yellow tea aqueous extract against N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis in rats by employing histological and biochemical methods. Materials and methods Wistar rats were divided randomly into four groups: control (I), yellow tea (II), NDEA (III), and yellow tea + NDEA (IV). Groups II and IV were exposed via a diet to yellow tea extract in a concentration of 10 g/kg feed; groups III and IV received 0.01% NDEA in drinking water. The experiment lasted for 13 weeks. Results Daily intake of yellow tea in an average dose of 800 mg/kg b.w. alleviated the carcinogenic effect of NDEA as evidenced by reversed histopathological changes towards normal hepatocellular architecture and decreased lipid peroxidation, protein carbonyl formation, and DNA degradation by 64%, 37% and 15%, respectively, as compared with values obtained in NDEA alone-treated rats. Treatment with yellow tea extract caused protection of superoxide dismutase (SOD) and catalase (CAT); their activity was recovered by 47% and 12%, respectively, as compared with the NDEAtreated rats. Moreover, the extract normalized the NDEA-induced activity of paraoxonase 1 (PON1) and glutathione peroxidase (GPx), while a further increase in the level of reduced glutathione (GSH) was noticed. Conclusions On the basis of these findings, it can be concluded that treatment with yellow tea partially protected the livers of rats from NDEA-induced hepatocarcinogenesis and that its antioxidant activity contributed to this effect. ARTICLE HISTORY

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Gallic acid: Molecular rival of cancer

Cited by 289 publications

References 159 publications

Anticancer activity of the “Hardaliye” on HT-29 Cell Line and proliferative activity on CF-1 cell line: Apoptosis and Antioxidant pathway responsive gene expressions

Anticancer activity of the “Hardaliye” on HT-29 Cell Line and proliferative activity on CF-1 cell line: Apoptosis and Antioxidant pathway responsive gene expressions

Secondary metabolites from endophytic fungus from Lippia sidoides Cham.

Protective effect of yellow tea extract on N-nitrosodiethylamine-induced liver carcinogenesis

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