Gallic acid loaded PEO-core/zein-shell nanofibers for chemopreventive action on gallbladder cancer cells

Acevedo, Francisca; Hermosilla, Jeyson; Sanhueza, Claudia; Mora-Lagos, Bárbara; Fuentes, Irma; Rubilar, Mónica; Concheiro, Angel

doi:10.1016/j.ejps.2018.04.009

Cited by 49 publications

(24 citation statements)

References 63 publications

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“…In one demonstration, coaxial electrospinning was used to develop gallic acid-loaded PEO@zein core−sheath nanofibers to improve the chemopreventive action of gallic acid on human gallbladder cancer cells. 988 Compared with the nanofibers loaded with a single drug, those containing multiple drugs are beneficial to overcoming the chemoresistance against a single drug. 977 For example, camptothecin-11 and 7-ethyl-10-hydroxycamptothecin, two antitumor drugs, were encapsulated in nanofibers made of a blend of poly(glycerol monostearate-co-ε-caprolactone) and PCL for local delivery.…”

Section: Electrospun Nanofibers For Biomedical Applicationsmentioning

confidence: 99%

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

et al. 2019

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Electrospinning is a versatile and viable technique for generating ultrathin fibers. Remarkable progress has been made with regard to the development of electrospinning methods and engineering of electrospun nanofibers to suit or enable various applications. We aim to provide a comprehensive overview of electrospinning, including the principle, methods, materials, and applications. We begin with a brief introduction to the early history of electrospinning, followed by discussion of its principle and typical apparatus. We then discuss its renaissance over the past two decades as a powerful technology for the production of nanofibers with diversified compositions, structures, and properties. Afterward, we discuss the applications of electrospun nanofibers, including their use as “smart” mats, filtration membranes, catalytic supports, energy harvesting/conversion/storage components, and photonic and electronic devices, as well as biomedical scaffolds. We highlight the most relevant and recent advances related to the applications of electrospun nanofibers by focusing on the most representative examples. We also offer perspectives on the challenges, opportunities, and new directions for future development. At the end, we discuss approaches to the scale-up production of electrospun nanofibers and briefly discuss various types of commercial products based on electrospun nanofibers that have found widespread use in our everyday life.

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Section: Electrospun Nanofibers For Biomedical Applicationsmentioning

confidence: 99%

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

et al. 2019

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“…Among polyphenolic acids, GA exhibits several biological relevant activities [19,51]. However, its therapeutic Pharmaceutics 2020, 12, 9 9 of 21 potential is also hampered by low bioavailability [52] and susceptibility to environmental factors [53], such as the tendency to easily oxidize at pH above 7 [54] giving rise to metabolites, namely 4-O-methyl gallic acid and pyrogallol, that possess lower antioxidant activity compared to GA.…”

Section: Polyphenols Entrapment Efficiencymentioning

confidence: 99%

Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infections

et al. 2019

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Vulvovaginal candidiasis (VVC) is a widely spread fungal infection that causes itching, pain and inflammation at the vaginal site. Although common, currently available treatment suffers from limited efficacy and high recurrence. In addition, the growing problem of resistance to azole drugs used in current treatments emphasizes the need for superior treatment options. Antimicrobial polyphenols are an attractive approach offering multitargeting therapy. We aimed to develop novel liposomes for simultaneous delivery of two polyphenols (quercetin, Q, and gallic acid, GA) that, when released within the vaginal cavity, act in synergy to eradicate infection while alleviating the symptoms of VVC. Q was selected for its anti-itching and anti-inflammatory properties, while GA for its reported activity against Candida. Novel liposomes containing only Q (LP-Q), only GA (LP-GA) or both polyphenols (LP-Q+GA) were in the size range around 200 nm. Q was efficiently entrapped in both LP-Q and in LP-Q+GA (85%) while the entrapment of GA was higher in LP-Q+GA (30%) than in LP-GA (25%). Liposomes, especially LP-Q+GA, promoted sustained release of both polyphenols. Q and GA acted in synergy, increasing the antioxidant activities of a single polyphenol. Polyphenol-liposomes were not cytotoxic and displayed stronger anti-inflammatory effects than free polyphenols. Finally, LP-GA and LP-Q+GA considerably reduced C. albicans growth.

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“…In addition, the effect of GA on the reduction of chronic degenerative diseases such as diabetes (Abdel-Moneim, El-Twab, Yousef, Reheim, & Ashour, 2018;Abdel-Moneim, Yousef, El-Twab, Reheim, & Ashour, 2017), obesity (Huang, Chang, Yang, Wu, & Shen, 2018), heart disease (Jin, Piao et al, 2017;Jin, Sun et al, 2018), and cancer (Liao, Chen, Huang, & Wang, 2018;Sales et al, 2018) has been studied. However, GA exhibits poor stability at high temperatures, in oxygen, in light, and in alkaline pH, in addition to its low absorption after oral administration (Acevedo et al, 2018). Therefore, the bioactivity of GA is affected and strategies to maintain it must be applied.…”

Section: Introductionmentioning

confidence: 99%

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Tapia-Hernández

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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Currently, electrospraying is a novel process for obtaining the nanoparticles from biopolymers. Zein nanoparticles have been obtained by this method and used to protect both hydrophilic and hydrophobic antioxidant molecules from environmental factors. The objective of this work was to prepare and characterize gallic acid‐loaded zein nanoparticles obtained by the electrospraying process to provide protection to gallic acid from environmental factors. Thus, it was related to the concentration of gallic acid in physicochemical and rheological properties of the electrosprayed solution, and also to equipment parameters, such as voltage, flow rate, and distance of the collector in morphology, and particle size. The physicochemical properties showed a relationship in the formation of a Taylor cone, in which at a low concentration of gallic acid (1% w/v), low viscosity (0.00464 ± 0.00001 Pa·s), and density (0.886 ± 0.00002 g/cm3), as well as high electrical conductivity (369 ± 4.3 µs/cm), forms a stable cone‐jet mode. The rheological properties and the Power Law model of the gallic acid‐zein electrosprayed solution demonstrated Newtonian behavior (n = 1). The morphology and size of the particle were dependent on the concentration of gallic acid. Electrosprayed parameters with high voltage (15 kV), low flow rate (0.1 mL/hr), and short distance (10 cm) exhibited a smaller diameter and spherical morphology. FT–IR showed interaction in the gallic acid‐loaded zein nanoparticle by hydrogen bonds. Therefore, the electrospraying process is a feasible technique for obtaining gallic acid‐loaded zein nanoparticles and providing potential protection to gallic acid from environmental factors.

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Gallic acid loaded PEO-core/zein-shell nanofibers for chemopreventive action on gallbladder cancer cells

Cited by 49 publications

References 63 publications

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infections

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

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